We also have guys that have been diagnosed with congestive heart failure from 20 IU rhGH daily
@Biggerp73 . So somewhere in between. Obviously, if you're looking for some clear dose/response for yourself, nobody knows. If I could predict the future, I'd be a trillionaire from the stock market; not posting about drugs on bodybuilding boards.
Cardiomyopathy secondary to chronic GH excess (concentric hypertrophy, increased LV mass [weight of the heart may increase up to 1300 g where < 250 g is normal]) correlates with duration more than dose, though structural changes can occur with short-term GH exposure. It is rare. GH/IGF-I exerts beneficial effects on cardiac growth and function within normal ranges (i.e., a Goldilocks problem: concentrations should be "just right.")
The natural history of cardiomyopathy secondary to chronic GH excess progresses through 3 stages:
1. The early stage is characterized by increased contractility, decreased vascular resistance, and a high cardiac output (not to be confused with systolic or diastolic BP; though systolic BP is a proxy for cardiac output interacting with pressure exerted against the arterial walls)... This stage has no demonstrable morphological abnormalities, although LVH has been observed without any evidence of diastolic dysfunction
2. The intermediate stage is characterized by biventricular hypertrophy, impaired diastolic filling, preserved systolic function at rest, and impaired exercise tolerance
3. In the late stage... cardiac chamber dilation, systolic dysfunction at rest, and congestive heart failure if left untreated
The effects of GH on cardiomyocyte growth and myocardial hypertrophy in GH excess differ from LVH caused by pressure overload. That is to say, controlling BP will not help you here.