First have to figure prenuclear affects, prior to the translocation. It begins after the conformational change with a cascade from the heat-shock proteins onward.
Methandienone and stanozolol both take longer before translocation to the nucleus, which may imply some other things. Testosterone translocates the fastest.
And sure there's polyvocal coding, transactivation, transrepression, regulatory feedback. I could always use help with this.
Still "Efficacy" is a notion that implies that these molecules have conscious intention, whereas they are simple unconscious codes. The form is the function and the function is the form. They simply ARE, and in order to study them, human intentions need to be phenomenologically reduced.
That was always drilled into my head.
"Efficacy" in reference that a particular molecule's ligand activity to induce a physiological response. Not trying engage in anthropomorphism of chemical compounds.