DNP - All the Info is Here!

[itcumsatnight]

They should be fine. They will still do the job.

Thanks boss! I trust your input. I'll give them a go. I imagine the worst-case scenario is they've lost some potency.

 

[itcumsatnight]

Doing an update just incase anyone is comes across this in the future and wonders if my 4 year old DNP was still good to go. Well, I ran it for 2 weeks and dropped 8 pounds. About 3 pound per week from the DNP and 1 pound from my deficit. Kind of wish I had more since I easily have another 10 pounds to lose. Cheers!

 

[Elvia1023]

I was doing more research and come across an article that we have spoken about before but figured I would repost it because it's very interesting.

Alzheimer's & Dementia​

Volume 13, Issue 5, May 2017, Pages 582-591

Perspective
DNP, mitochondrial uncoupling, and neuroprotection: A little dab'll do ya​

Author links open overlay panelJohn G. Geisler a, Krisztina Marosi b, Joshua Halpern b, Mark P. Mattson b c

Abstract​

Recent findings have elucidated roles for mitochondrial uncoupling proteins (UCPs) in neuronal plasticity and resistance to metabolic and oxidative stress. UCPs are induced by bioenergetic challenges such as caloric restriction and exercise and may protect neurons against dysfunction and degeneration. The pharmacological uncoupler 2,4-dinitrophenol (DNP), which was once prescribed to >100,000 people as a treatment for obesity, stimulates several adaptive cellular stress-response signaling pathways in neurons including those involving the brain-derived neurotrophic factor (BDNF), the transcription factor cyclic AMP response element-binding protein (CREB), and autophagy. Preclinical data show that low doses of DNP can protect neurons and improve functional outcome in animal models of Alzheimer's and Parkinson's diseases, epilepsy, and cerebral ischemic stroke. Repurposing of DNP and the development of novel uncoupling agents with hormetic mechanisms of action provide opportunities for new breakthrough therapeutic interventions in a range of acute and chronic insidious neurodegenerative/neuromuscular conditions, all paradoxically at body weight–preserving doses.

 

[Kauto_star]

Quick question - I am doing a 7 day 400mg per day run of DNP. Going to keep protein high, carbs lowish, and fats low & water high.

What have you guys done after your DNP run?

It worked well for me last time but I can't remember what my diet was like after my last DNP dose. Do you guys introduce carbs and foods slowly or do you pretty much get back in to a normal food intake and use the benefit of post-dnp recomp to some degree?

Thank you.