Hey Elvia, late sixties female, probably 5' 6" 170-180 recent total knee replacement. Never drank was not ridiculously unhealthy, normal active wife,mom etc. probably part genetic predisposition part diet for the cause. It's getting bad now due to age and inactivity. She was walking daily before surgery. Recovery is slow with these operations in older people. I worry if she doesn't reverse this soon she may need a transplant and it's a long shot to get one. The studies that I saw on methyl ether end were amazing. I figured regular dnp would work also just affect the rest of the body as well as the liver. So far it seems like 100 mg per day would be a tolerable dose? I've never used dnp. I kind of wish I had now so I would know a bit more, real world. Thank you for the reply.