Do Esters change how the hormones react in the body?

[Stewie]

This should give you a brief description.

The androgen receptor DNA-binding domain determines androgen selectivity of transcriptional response - PubMed

The AR (androgen receptor) is a hormone-dependent transcription factor that translates circulating androgen hormone levels into a physiological cellular response by directly regulating the expression of its target genes. It is the key molecule in e.g. the development and maintenance of the male...

pubmed.ncbi.nlm.nih.gov

 

[Kaladryn]

This should give you a brief description.

The androgen receptor DNA-binding domain determines androgen selectivity of transcriptional response - PubMed

The AR (androgen receptor) is a hormone-dependent transcription factor that translates circulating androgen hormone levels into a physiological cellular response by directly regulating the expression of its target genes. It is the key molecule in e.g. the development and maintenance of the male...

pubmed.ncbi.nlm.nih.gov

That is great stuff, thank you! I found the whole paper on Research Gate! This is stuff they had no idea about in some of my basic undergrad classes back in the 90s that now they seem to know much more about.

 

[Stewie]

That is great stuff, thank you! I found the whole paper on Research Gate! This is stuff they had no idea about in some of my basic undergrad classes back in the 90s that now they seem to know much more about.

Most of the biomolecular interactions with stuff like AAS won't be found in any cell biology/biochem books. It's more of an understanding of how translation of RNA, DNA, and molecules (generally small molecules) are transcribed by motifs.

Off in a slightly different direction. With all this going on with the adjuvant use of Zn (zinc), those whom may have been a bit on the Zn insufficiency side of normal. Theses individuals may more than likely notice a bit better responsiveness from their AAS. This would be mediated by less than stellar amounts of Zn to facilitate in proper motif translation.

There's the hype of Zn acting as a nutraceutical AI. Well, not necessarily, Zn is essential for several enzymatic pathways, i.e., zinc importers, zinc transporters, zinc-sensing transcription factors, ect that are heavily Zn dependant. So, if one's Zn status is subpar, this would reflect the noticable reduction in E2 once they started supplementing with Zn.

 

[Jaxz]

Pinning schedule is key to any ester . To keep blood levels even always even on trt . I pin long esters at least 3 times a week even if I'm on 150mgs per week . Short esters should be pinned Ed or at least every other day u can use slin pins to help and to also get more pinning sites in without to much muscle scaring .

All this in my opinion of course