- Joined
- Apr 9, 2021
- Messages
- 1,701
So, the question is what are the down sides and side effects of high e1 ?
As mentioned, E1's relative binding affinity for the ERs is about 5-8% (and it has reduced potency). Basically, it's a VERY weak estrogen (so EQ only, or EQ in combination with anything other than a "test base" would feel like "low E2" to most).But high E1 can give us any issues?