As far as tissue damage, I’m not suggesting that’s a sure thing, but imagine someone who for whatever reason has a slight or somewhat noticeable inflammatory reaction at the injection site. I’ve seen hundreds of posts and had many clients and know others who this has happened to. You then - because you’re trying to specifically inject in a particular area (in reality, spreading the injections around somewhat makes more sense) - you piggy back another injection into an already inflamed area multiple times daily for months on end.
Plus as Matsuo mentioned, there’s the number of injections. Just inserting a needle in the same area repeatedly creates some trauma, albeit it very minimal. An foot is not much in the context of a mile, but a thousand feet is a different story.
I’ve known folks to get numbness from injections and insulin certainly can create local epidermis issues and it’s just “water based.”
There might just be a reason why you see a warning against this on the package inserts for several of the main pharm GH brands, too.
Good news:
www.ncbi.nlm.nih.gov
-S