Does inject site matter for HGH?

[xpoc]

I assumed sub Q would be equally effective regardless of injection site. UNTIL, I found this study that says abdominal site is more effective than in thigh.

The effect of subcutaneous injection site on absorption of human growth hormone: abdomen versus thigh - PubMed

Subcutaneously injected GH is better absorbed from the abdominal site than from the thigh.

pubmed.ncbi.nlm.nih.gov

Conversely, I saw this video by Jay Campbell and Hunter Williams that states you can get insulin insensitivity in the injection site. If this is true, injecting into the abdominal area all the time could lead to problems.

https://www.facebook.com/video.php?v=1129711641485403

So it is a conundrum. Anyone have better info on this?

 

[sciroxx-lab]

Thank you for the interesting post. As I was reading through this article and similar studies on HGH subcutaneous absorption, such as https://pubmed.ncbi.nlm.nih.gov/7514513/e, I humbly assume that absorption in the abdominal area is simply faster.

Referring to the observation from the article you mentioned—'Serum IGF-1 (insulin-like growth factor I) at 12 and 24 hours showed a significant rise from baseline levels, but no significant difference was observed between the two injection sites'—it suggests that the overall effect remains similar, with the only difference being in the pharmacokinetics of HGH

 

[mexbeast]

I would like it if my fat became insulin resistant! The muscles though i want as sensitive to insulin as possible

 

[Flocci]

But is faster better? I believe we see a better IGF1 response subQ but I might be misremembering.

Faster might be better for the fatloss effects as they are more acute compared to the increased IGF1 from GH. But take what I'm saying with a big grain of salt.

 

[SlinMan!]

Always sub-q

 

[xpoc]

Thank you for the interesting post. As I was reading through this article and similar studies on HGH subcutaneous absorption, such as https://pubmed.ncbi.nlm.nih.gov/7514513/e, I humbly assume that absorption in the abdominal area is simply faster.

Referring to the observation from the article you mentioned—'Serum IGF-1 (insulin-like growth factor I) at 12 and 24 hours showed a significant rise from baseline levels, but no significant difference was observed between the two injection sites'—it suggests that the overall effect remains similar, with the only difference being in the pharmacokinetics of HGH

So in laymen terms, it doesn't matter where you inject sub Q because the end result will be the same? With abdominal being faster absorbed and thigh being slower? And what is your take on the Hunter Williams/Jay Campbell stating the injection site area can become insulin resistant? Thanks man, always value your view input on shit I don't understand.

 

[buck]

In the end whether something is absorbed a little faster or not i tend to think the results end up about the same for most people. As it gets in the body fast or slower. Now if i was looking to get high then faster may be better. But as muscle growth as well as with other functions in the body it tends to be what happens over a longer period that causes the effects most BBer's are looking for.

 

[Biggerp73]

I like IM into the bicep

 

[Murph6969]

Sub Q in the stomach for me

 

[xpoc]

Sub Q in the stomach for me

Check the vid I posted. These guys believe that you injection site (stomach) can become insulin resistant. BUT, the study shows that hgh is better absorbed in the abdomen than thigh when both are administered sub Q. So, it is a conundrum. I don't want my stomach area (injection site) to become insulin resistant, but that area appears to be where it is best absorbed.

 

[JUICEDUP3]

how often do you all take the metformin? daily, 3x a week, or whats recommended?

im sure it depends on gh dosing, but lets say 4-5 iu daily

 

[TexasBoy]

Always do sub-q

 

[Goodfella1988]

Subq in thigh

 

[mexbeast]

Check the vid I posted. These guys believe that you injection site (stomach) can become insulin resistant. BUT, the study shows that hgh is better absorbed in the abdomen than thigh when both are administered sub Q. So, it is a conundrum. I don't want my stomach area (injection site) to become insulin resistant, but that area appears to be where it is best absorbed.

Is your abdomen fat free? Are like 8% bf or less? If so maybe your concern is warranted, if not then it's a good thing to get that area insulin resistant, why? Because in that case you wouldn't store any fat in there. If the muscles become insulin resistant then there's a problem!
Edit. I guess maybe they are referring to the use of insulin in the abdomen, in that case yes you would become resistant to the insulin

 

[xpoc]

Is your abdomen fat free? Are like 8% bf or less? If so maybe your concern is warranted, if not then it's a good thing to get that area insulin resistant, why? Because in that case you wouldn't store any fat in there. If the muscles become insulin resistant then there's a problem!
Edit. I guess maybe they are referring to the use of insulin in the abdomen, in that case yes you would become resistant to the insulin

Right now I am pretty close to 8%. But I have enough fat to still get it sub q and not into the muscle. I was considering going into the thigh based on the insulin desensitization thing, but then I saw that the abdominal area absorbs the GH better so I am still going there. Like I said, it is a conundrum.

 

[danieltx]

Ok guys, let me clear this up - this is something no serious bodybuilder has ever thought about. If the areas you inject GH become insulin resistant then every bodybuilder would be insulin resistant in every muscle and they'd get smaller and flatter through their offseasons.

 

[curcumin]

There is some evidence that site injection can cause local fatloss - its from a mechanical function of lacerating the fat cells. It is called lipodystrophy and I have experienced it myself.

But there is no local insulin resistance. That effect is systemic.

 

[Steve123]

I like IM into the bicep

Interesting. Is this just a preference or is there a scientific purpose for IM Bicep?

 

[Biggerp73]

Interesting. Is this just a preference or is there a scientific purpose for IM Bicep?

No reason except it's the only easy to access/painless site that I don't use for oils and thus is always fresh

 

[MackCoach]

I like IM into the bicep

me too
IM no belly fat pins
forearms too
ventroglute
des and slin like that
slin pin at all sites