My HRT doctor is pretty knowledgeable and up-to-date. She is a big believer in levels being in range but in the high-end of the range no matter what age you are. For example she agrees that every day intramuscular injections of testosterone cypionate are better than two or three shots a week. She has me on 20mg cyp IM everyday and .25mg adex 2x per week. Test comes back around 800 range 250-827. Estrogen at 22. Anyway like most of us I suffer from high hemoglobin even after doing phlebotomies every three months so what she told me today I found interesting. She said testosterone cypionate is metabolized by the liver which is the reason why hemoglobin can increase so high. She said test cream will not increase hemoglobin the same as cypionate will and you can still be in the 800 range. But then she said what she prefers even more that has the least likelyhood of increasing hemoglobin is replacing HRT with Clomid. She said she has patients on Clomid and their levels are in the 900s thousands and even 1200s without hemoglobin being increased. I found it interesting that the type of testosterone you take for HRT can effect hemoglobin. I’m thinking about dropping the cypionate and trying Clomid for a couple months with adex to keep estrogen in range and see what my levels are and what impact it has on my hemoglobin. Curious on your input?