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Dutasteride 0.5 mg twice per week = Finasteride 5 mg daily w/ Less Side effects

^^^COULD NOT AGREE MORE
(..he's also a bit of a wiz on other topics too ..the info BB provides makes a solid foundation for a GREAT discussion ..it invites other experienced "thinking" minds)

^^^THANK YOU @Black Beard
..for the deep-dive on these topics
&
..for your patience in answering the board-member's questions

^^^this is a HUGE service to our community!!!!!

.
True story.

He is a class act. He gives and gives and gives and never complains and he has the patience of a saint. Clone him.
 
Optimizing vitamin D
Proper Vit. D (or, more precisely, proper VDR receptor activation) is paramount for hair growth, but...
A recent transcriptional study recognized that the gene CYP27B1 is under-expressed in balding hair follicles. This gene codes for the monooxygenase enzyme that metabolizes 25-OH vitamin D into its active form 1,25-OH. Because magnesium supplementation was able to correct serum vitamin D concentrations without the need for changes to vitamin D intake, it is feasible that magnesium deficiency is a bottleneck to the function of metabolizing enzymes that rely on NADPH, which is renewed via a magnesium-dependent system. One study confirmed that magnesium deficiency was common in subjects with AGA.
Androgenetic Alopecia sufferers should make sure their Mg intake is adequate or they may bypass the impaired conversion issue by supplementing Calcitriol (the biologically active form of vitamin D) rather than cholecalciferol.
 
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@Black Beard I’ve asked you this before…but I can’t seem to find it.

If someone has been slick bald 10 years on the top of head in some spots, is there any reason to even attempt the dutasteride/min/microdem things?
 
Proper Vit. D (or, more precisely, proper VDR receptor activation) is paramount for hair growth, but...
A recent transcriptional study recognized that the gene CYP27B1 is under-expressed in balding hair follicles. This gene codes for the monooxygenase enzyme that metabolizes 25-OH vitamin D into its active form 1,25-OH. Because magnesium supplementation was able to correct serum vitamin D concentrations without the need for changes to vitamin D intake, it is feasible that magnesium deficiency is a bottleneck to the function of metabolizing enzymes that rely on NADPH, which is renewed via a magnesium-dependent system. One study confirmed that magnesium deficiency was common in subjects with AGA.
Androgenetic Alopecia sufferers should make sure their Mg intake is adequate or they may bypass the impaired conversion issue by supplementing Calcitriol (the biologically active form of vitamin D) rather than cholecalciferol.

Yep, maxing out nutrition; micro nutrients (iron, vit D, zinc, mag , maintenance cals etc) is definitely a bonus that can help duta/minox possibly work better. Lifestyle like lowering stress / good sleep may also help.


@Black Beard I’ve asked you this before…but I can’t seem to find it.

If someone has been slick bald 10 years on the top of head in some spots, is there any reason to even attempt the dutasteride/min/microdem things?


It's much less likely to work but not impossible. Also, you can grow enough back as an excellent responder, you could possibly use the side hairs as donor for transplant. There are a lot of variables. Some severely bald people have recovered their hair, but this is all genetic response to the meds
 
@Black Beard I’ve asked you this before…but I can’t seem to find it.

If someone has been slick bald 10 years on the top of head in some spots, is there any reason to even attempt the dutasteride/min/microdem things?
I had been ‘bald’ for more than 10 years and grew back a significant amount of hair. There is a foto here somewhere in this valuable thread of my head. While far far from having a head of hair of my youth, it’s better than nothing, have nothing to lose and is dirt cheap to boot. Why not ? especially with his dosing schedule to mitigate sides.

What was first lost will be the last to regrow . . . if ever (my case).
 
@Black Beard , thanks for the great thread. I have been on .25 fin everyday per your other hair loss thread.

Gonna switch over to DUT next week when I get back from vacation.

Question, just got my hands on 2.5mg oral minoxidil. As far as hair shedding on the oral version what should be expected and for how long ?

Of is the oral version different than the topical.
 
@Black Beard , thanks for the great thread. I have been on .25 fin everyday per your other hair loss thread.

Gonna switch over to DUT next week when I get back from vacation.

Question, just got my hands on 2.5mg oral minoxidil. As far as hair shedding on the oral version what should be expected and for how long ?

Of is the oral version different than the topical.

Some people don't even shed, so no way to know.. Oral is generally much more effective than topical.


I recommend waiting 30 days between your last finasteride dose and your first dutasteride dosage.

You want the fin out of your system completely before introducing dutasteride to prevent side effects
 
Some people don't even shed, so no way to know.. Oral is generally much more effective than topical.


I recommend waiting 30 days between your last finasteride dose and your first dutasteride dosage.

You want the fin out of your system completely before introducing dutasteride to prevent side effects
A bit off topic but since you're active in this thread wanted to ask.

I've used everything and in high doses. I've never lost a hair on my head - if anything I've gained hair on my body.

My mother's father was thinning strongly by his 40s. My dad was thinning strongly by his early 30s (I'll be 38 next month).

What do you attribute my lack of hair loss to? Just good genetic?
 
A bit off topic but since you're active in this thread wanted to ask.

I've used everything and in high doses. I've never lost a hair on my head - if anything I've gained hair on my body.

My mother's father was thinning strongly by his 40s. My dad was thinning strongly by his early 30s (I'll be 38 next month).

What do you attribute my lack of hair loss to? Just good genetic?
It's because you don't inherit every single gene from your parents.


Basically, your parents can carry various copies of genes that you inherit from them but they don't necessarily express.


Example. A brown eyed man and brown eyed woman have a green eyed son. The man and the woman carry a copy of green eye genes, but you need two copies to actually have green eyes, since the parents only each had one copy, they dont have green eyes, but their son got one copy from each of them, so with two copies, he now has green eyes .


Its the same reason the sibling from the same couple may have brown eyes if that sibling doesnt inherit the two copies he needs to "express" or have the green eyes.


You parents likely carried good hair genetics and you got lucky and inherited the good ones. We all carry genes that we don't always express in ourselves but can pass onto our offsprings.
 
It's because you don't inherit every single gene from your parents.


Basically, your parents can carry various copies of genes that you inherit from them but they don't necessarily express.


Example. A brown eyed man and brown eyed woman have a green eyed son. The man and the woman carry a copy of green eye genes, but you need two copies to actually have green eyes, since the parents only each had one copy, they dont have green eyes, but their son got one copy from each of them, so with two copies, he now has green eyes .


Its the same reason the sibling from the same couple may have brown eyes if that sibling doesnt inherit the two copies he needs to "express" or have the green eyes.


You parents likely carried good hair genetics and you got lucky and inherited the good ones. We all carry genes that we don't always express in ourselves but can pass onto our offsprings.
Your explanation takes me back to grade school and the Punnett Square. I think eye color was the way it was taught to us as well.
 
Basically, your parents can carry various copies of genes that you inherit from them but they don't necessarily express.
It’s called allele. You get one allele from your mother and one from your father for the same gene.
Not all of alleles should be expressed in pairs to be a part of your phenotype. If for example the allele for black eye is dominant, you can have two or one allele for black eye and you will in both cases have black eye.
But green eye is for example a recessive allele, meaning you need both pairs of it to be expressed to be visible in your phenotype.
Just for your information. I like to discuss on these sort of stuff
 
For those asking about dutasteride or those saying they can't use finasteride even at low dosages; Dutasteride at a dosage of 0.5 mg twice per week will generally lower DHT by 70%, the same as 5 mg finasteride. In fact, it may be better since finasteride has a spread of 50-90% DHT reduction depending on the individual whereas dutasteride is more consistent at lowering DHT.


The studies also show a slight advantage in hair regrowth from 0.5 mg dutasteride x 2 per week versus 5 mg finasteride daily.


Anecdotally, MANY patients who could not touch finasteride even at low doses have no side effects from dutasteride or only very mild ones. (slight libido reduction, slight brain fog). Often resolving with time on their own.
(https://pubmed.ncbi.nlm.nih.gov/15363566/ " Onset of new drug-related adverse events were reported most frequently at the start of therapy and declined over time in patients receiving dutasteride.")


I will add that Finasteride has one effect that dutasteride does not that may be the reason side effects can be severe for some on finasteride but not on dutasteride. Finasteride inhibits an enzyme called PEMT. This enzyme is responsible for converting noradrenaline into adrenaline and also for producing choline. Both noradrenaline and choline can effect mood and cognition. (Anti-depressants like wellbutrin can increase/affect noradrenaline and anti-alzheimers drugs increase choline or acetylcholine effects in the body).


Another thing i will add is that as we get older, BPH/prostate growth can become a real problem, especially for men using AAS and HGH. This decreases quality of life and recovery as you wake up multiple times during the night to urinate. A 5-alpha reductase inhibitor can still shrink the prostate even on high doses of AAS/testosterone as DHT is the main driver of this growth/swelling effect, as always, prevention is the BEST medicine there is.

Just an FYI here.

0.5 Dutasteride is only available (here) in capsules, not in tablet form.

Had to school my dermatologist about this. He said it was only available in 5mg doses. Wrongo.
 
It’s called allele. You get one allele from your mother and one from your father for the same gene.
Not all of alleles should be expressed in pairs to be a part of your phenotype. If for example the allele for black eye is dominant, you can have two or one allele for black eye and you will in both cases have black eye.
But green eye is for example a recessive allele, meaning you need both pairs of it to be expressed to be visible in your phenotype.
Just for your information. I like to discuss on these sort of stuff
Off topic I know . . . how do you explain one green eye and one blue eye. (Had a girlfriend like that.)
 
Your explanation takes me back to grade school and the Punnett Square. I think eye color was the way it was taught to us as well.
Exactly
It’s called allele. You get one allele from your mother and one from your father for the same gene.
Not all of alleles should be expressed in pairs to be a part of your phenotype. If for example the allele for black eye is dominant, you can have two or one allele for black eye and you will in both cases have black eye.
But green eye is for example a recessive allele, meaning you need both pairs of it to be expressed to be visible in your phenotype.
Just for your information. I like to discuss on these sort of stuff

Correct, i always explain things as plainly and simple as i possibly can. Adding more scientific nomenclature will complicate the message further.

Off topic I know . . . how do you explain one green eye and one blue eye. (Had a girlfriend like that.)

It's a similar concept, but an extremely rare gene/mutation. I looked up the stats just now and it's something like 1% of the population.
 
Hi BB, thks for the great share. Btw, when using Keto shampoo do we only apply on targeted areas or whole head ? TIA
 
Hi BB, thks for the great share. Btw, when using Keto shampoo do we only apply on targeted areas or whole head ? TIA

Whole head is fine. Minimum 5 minutes before rinse. Using 2-3 times per week max and a good conditioner for dry scalp to prevent frizziness/dry scalp.
 
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@Black Beard , thanks for the great thread. I have been on .25 fin everyday per your other hair loss thread.

Gonna switch over to DUT next week when I get back from vacation.

Question, just got my hands on 2.5mg oral minoxidil. As far as hair shedding on the oral version what should be expected and for how long ?

Of is the oral version different than the topical.
FWIW I started 2.5mg minox oral last year and shed pretty hard for about 5 months. It has since stopped and things are leveling out now. It does vary for a lot of people though. My advice is to stick with it if you do shed and don’t let it scare you away.
 
Whole head is fine. Minimum 5 minutes before rinse. Using 2-3 times per week max and a good conditioner for dry scalp to prevent frizziness/dry scalp.
Which conditioner do you use? Never used one before.
 
Which conditioner do you use? Never used one before.

Personally, i use head & shoulders 2 in 1 almond oil shampoo and conditioner. Its made for dry scalp.


It has 1% pyrrithione zinc which is also really good for hair and scalp. Its incredible for preventing itchy scalp and dandruff, especially with ketoconazole.
 

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