- Joined
- Jun 16, 2013
- Messages
- 1,197
after seeing Emeric mention that "high elevated out of range androgen can damage the neurons in your brain" i found more data indicating it leads to changes in behavior, mood, and memory.
"results suggest that elevated concentrations of testosterone can induce programmed cell death, which is characterized by a decrease of cell viability, an increase in the number of annexin V-positive cells, DNA fragmentation, and caspase activation. Apoptotic parameters are blocked or diminished by InsP3R inhibitors and the specific knocking down of InsP3R type 1, indicating that this isoform is a key regulator in this event. Overall, the conclusions from these studies are that normal levels of testosterone are necessary for the normal Ca2+ response and to maintain homeostasis, but elevated concentrations produce altered Ca2+ signal, leading to deleterious effects in neurons."
Elevated Testosterone Induces Apoptosis in Neuronal Cells
**broken link removed**
High levels of testosterone affect parts of the brain linked with emotion | Daily Mail Online
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330791/
Elevated testosterone levels — Having too high of testosterone levels has been proven to be detrimental to your brain’s health and does kill brain cells. If you are taking supplements that increase testosterone levels, be aware that too much of the supplement could potentially cause the death of your brain cells:
https://wakeup-world.com/2012/01/28/50-situations-that-can-kill-brain-cells/
"results suggest that elevated concentrations of testosterone can induce programmed cell death, which is characterized by a decrease of cell viability, an increase in the number of annexin V-positive cells, DNA fragmentation, and caspase activation. Apoptotic parameters are blocked or diminished by InsP3R inhibitors and the specific knocking down of InsP3R type 1, indicating that this isoform is a key regulator in this event. Overall, the conclusions from these studies are that normal levels of testosterone are necessary for the normal Ca2+ response and to maintain homeostasis, but elevated concentrations produce altered Ca2+ signal, leading to deleterious effects in neurons."
Elevated Testosterone Induces Apoptosis in Neuronal Cells
**broken link removed**
High levels of testosterone affect parts of the brain linked with emotion | Daily Mail Online
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330791/
Elevated testosterone levels — Having too high of testosterone levels has been proven to be detrimental to your brain’s health and does kill brain cells. If you are taking supplements that increase testosterone levels, be aware that too much of the supplement could potentially cause the death of your brain cells:
https://wakeup-world.com/2012/01/28/50-situations-that-can-kill-brain-cells/