Endocrinology Journal Entry on Anabolics

[Kendrxck]

http://www.endocrine.org/~/media/en...HR/57/RPHR_vol_57_ch_19_anabolic_steroids.pdf

Page 10-11 is of particular interest...

 

[asteelz]

Cool find

 

[b_cornelius]

...does anyone want to start an article about something that is up to date?

We could explore the Androgen Response Elements and various proteins that may affect this.

But first we should explore the various points of action for Androgens.

1.) There is that membrane-bound receptor that supposedly mediates some of the immediate effects and "non-AR effects"

2.) Intracellular-cytoplasmic effects. When the androgen binds to the androgen receptor, the conformational change immediately affects cellular pathways. Then the AR switches it's heat-shock-protein chaperone and translocates to the nucleus.

3)AR nuclear effects, then, are some of the traditionally conceived actions of Androgens. Varies in conjunction with Androgen Response Elements.

 

[Stewie]

...does anyone want to start an article about something that is up to date?

We could explore the Androgen Response Elements and various proteins that may affect this.

But first we should explore the various points of action for Androgens.

1.) There is that membrane-bound receptor that supposedly mediates some of the immediate effects and "non-AR effects"

2.) Intracellular-cytoplasmic effects. When the androgen binds to the androgen receptor, the conformational change immediately affects cellular pathways. Then the AR switches it's heat-shock-protein chaperone and translocates to the nucleus.

3)AR nuclear effects, then, are some of the traditionally conceived actions of Androgens. Varies in conjunction with Androgen Response Elements.

Then along comes the savage glucophage engulfed in deoxyhemoglobin (hypoxia-anoxia) docking in the NH2-terminal transactivation domain or is it the Ligand-Binding Domain??? Uh, it's one of the four domains....I think....Annihilating the androgen receptor long before the induction of dissociation of the androgen receptor from heat shock protein.