Stewie
Featured Member / Verified Customer
Featured Member
Kilo Klub Member
Registered
Verified Customer
- Joined
- Feb 3, 2011
- Messages
- 5,178
Caber damaging the heart , i would never take it
The contingency of valvulopathy from cabergoline is spewed-out as absolute. Incidentally, these individuals that continually regurgitate thee-lore of absolute have not looked at clinical data. This same homology is spoken by the unscholarly stating testosterone replacement is a common theme for CVD. I'm sure my commentary will be taken out of context by those whom choose to rebuttal.
Here's a good start to further your reading pleasures.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070051/ "The Third Case of Cabergoline-Associated Valvulopathy: The Value of Routine Cardiovascular Examination for Screening" "In conclusion, it is reassuring to endocrinologists (and patients) that the prevalence of CAV in patients with prolactinoma is extremely low." "Given this low prevalence, routine screening with echocardiography is not indicated. The recommended screening procedure should be an annual cardiovascular examination, with echocardiography reserved for patients with a murmur or those with high cumulative cabergoline doses."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240058/ "Cabergoline appears to be safe in patients with prolactinoma up to the cumulative dose of ~300 mg. The screening for valvulopathy should be restricted to those with higher cumulative cabergoline exposure."
In an cumulative dose dependant manner, it *might* induce valvular disease.
By cumulative, there's several different longitudinal studies looking at structural changes, some of these patients were Rx'd 6-12grams per day (Parkinson's disease dosages) exceeding an cumulative dosage of >1000 mg without or very minimal, reversible valvular disease. Then there's been similar studies showing permanent structural damage. These were dosages that were taken for years. Not some miniscule 0.25mg (twice-weekly) for short periods of time.
It's like saying, "you'll develop cirrhosis if you drink alcohol". Yeah, sure in an abusive manner or you have a genetic predisposition to some hepatic disease, or inclusion of hepatotoxic drugs that potentiate the ethanol damaging effects from alcohol to your liver.