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I came across a claim by someone on the forum that products using 100% ethyl oleate (EO) as carrier are healthier since they allow a lower dosage of (kidney toxic) BA and BB. I'd like to hear some feedback on this without calling anyone out.
I agree that BA and BB have their down sides, but I haven't heard much positive about EO either. To my knowledge there are no safety studies for the use of EO for injectable products. In fact, there is some speculation that EO acts as a toxic mediator of ethanol poisoning. And I'm aware of one study that shows direct cardiotoxic effects of EO in vitro and in vivo.
Of course it's all dose-dependent, and it may well be that using 10% EO in order to reduce the BB dosage may be overall beneficial for health. The reason being that in that case the amount of EO would be too low to induce cardiac damage, while the amount of BB would be too low to induce kidney damage. Alternatively, one could stick to low dosed products which don't need much solvents like BB and EO in the first place. That would probably be the best option.
So while I agree that low amounts of EO can be beneficial from a health perspective, I'd have serious reservations about injecting hundreds of milliliters of EO during a cycle. Also, avoiding ultra high-dosed products (500mg+) may be a good idea as well if one is concerned about the negative health effects of solvents.
Another point are possible allergic reactions to EO, but that's a whole other discussion, just wanted to push back a bit against the specific claim mentioned above.
I agree that BA and BB have their down sides, but I haven't heard much positive about EO either. To my knowledge there are no safety studies for the use of EO for injectable products. In fact, there is some speculation that EO acts as a toxic mediator of ethanol poisoning. And I'm aware of one study that shows direct cardiotoxic effects of EO in vitro and in vivo.
https://journals.lww.com/cardiovasc...Cell_Damage_by_Fatty_Acid_Ethyl_Esters.1.aspxFatty acid ethyl ester (FAEE), a myocardial metabolite of ethanol, causes mitochondrial dysfunction in vitro in rabbits. We investigated the effect of these esters on rat heart mitochondria in vitro and in vivo. In vitro studies were conducted to investigate the binding of ethyl oleate (FAEE) to mitochondria and their capacity to hydrolyze these FAEE. In vivo effects of ethyl esters were studied by the direct transfer of [3H]oleate into the myocardium. Mitochondria were prepared from the myocardium of injected rats, and the amount of [3H]oleate bound to them was determined. In another in vivo study, 50 μl of 50 μM cold oleic acid ethyl ester was injected into the rat myocardium and the histopathological changes induced by oleic acid ethyl ester were examined by light microscopy. Our results show that fatty acid ethyl ester can bind to myocardial mitochondria in vitro as well as in vivo and the mitochondria can hydrolyze FAEE to fatty acid, which is a known uncoupler of oxidative phosphorylation. Of the total ethyl [3H] oleate injected, 8 μM [3H]oleate and 1 μM ethyl [3H]oleate was bound to the mitochondria. Significant myocardial cell damage was first observed on day 4 and markedly increased on day 30 after ethyl ester injection, with cells showing gross deformation and enlargement. However, no significant histopathological changes were observed in the myocardial tissue on day 2 after injection. Our results suggest that the FAEE may damage the myocardial cells as well as the mitochondria and may provide a metabolic link between ethanol abuse and myocardial dysfunction.
Of course it's all dose-dependent, and it may well be that using 10% EO in order to reduce the BB dosage may be overall beneficial for health. The reason being that in that case the amount of EO would be too low to induce cardiac damage, while the amount of BB would be too low to induce kidney damage. Alternatively, one could stick to low dosed products which don't need much solvents like BB and EO in the first place. That would probably be the best option.
So while I agree that low amounts of EO can be beneficial from a health perspective, I'd have serious reservations about injecting hundreds of milliliters of EO during a cycle. Also, avoiding ultra high-dosed products (500mg+) may be a good idea as well if one is concerned about the negative health effects of solvents.
Another point are possible allergic reactions to EO, but that's a whole other discussion, just wanted to push back a bit against the specific claim mentioned above.