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Female HRT stuff

I may have to seek out a HRT clinic. The doctor would not prescribe an injectable, but switched her to a patch that is changed twice weekly. I don't know how long is a reasonable time to evaluate whether or not it will make a difference.

She did give her a lab order to go check testosterone, so we'll find out where she is there.

By the way, her progesterone came back at 8.6. Over the last few years it has fluctuated from 3.9 to 8.6 (this has been her highest reading; dose of oral progesterone at night has been constant). I don't know how to read those labs; they're "green" on Quest's range.
 
I may have to seek out a HRT clinic. The doctor would not prescribe an injectable, but switched her to a patch that is changed twice weekly. I don't know how long is a reasonable time to evaluate whether or not it will make a difference.

She did give her a lab order to go check testosterone, so we'll find out where she is there.

By the way, her progesterone came back at 8.6. Over the last few years it has fluctuated from 3.9 to 8.6 (this has been her highest reading; dose of oral progesterone at night has been constant). I don't know how to read those labs; they're "green" on Quest's range.

The patch can sometimes get levels to optimal, but most need two patches at the same time of the strongest dosage, changed twice weekly. They are kind of annoying if you work out, go swimming/beach, etc


The low doses most prescribe will at best help a little bit with hot flashes and vaginal dryness, but none of the real benefits of properly restoring E to youthful/premenopausal levels.

Is the progesterone in ng/mL? For half the month, P will be undetectable, peaking on day 21.

Timing is extremely important to interpret female labs.

E can be menopausal level in early follicular phase (days 1-7) and peaks around days 9-14 (late follicular-ovulation). Luteal phase is when P starts to rise .

The timing only matters before menopause when there is still a cycle. At menopause, levels are fairly stable.
 
The patch can sometimes get levels to optimal, but most need two patches at the same time of the strongest dosage, changed twice weekly. They are kind of annoying if you work out, go swimming/beach, etc


The low doses most prescribe will at best help a little bit with hot flashes and vaginal dryness, but none of the real benefits of properly restoring E to youthful/premenopausal levels.

Is the progesterone in ng/mL? For half the month, P will be undetectable, peaking on day 21.

Timing is extremely important to interpret female labs.

E can be menopausal level in early follicular phase (days 1-7) and peaks around days 9-14 (late follicular-ovulation). Luteal phase is when P starts to rise .

The timing only matters before menopause when there is still a cycle. At menopause, levels are fairly stable.
Ng/ml and she has had a total hysterectomy, so I'm just trying to figure out if she's in a decent range. It's hard to read Quest's ranges because they're making assumptions based on time of month.
 
Ng/ml and she has had a total hysterectomy, so I'm just trying to figure out if she's in a decent range. It's hard to read Quest's ranges because they're making assumptions based on time of month.

Is she taking the P before blood draw? How many hours? It peaks around 2-4 hours and drops quite fast in most people, so testing for it is kind of tricky.
 
Is she taking the P before blood draw? How many hours? It peaks around 2-4 hours and drops quite fast in most people, so testing for it is kind of tricky.
Ahh I see. No. She takes it before bed.

I will say that since switching to the patch, she seems to have a bit more energy. Maybe it's too early to judge. Her anxiety is still out of control but that could be unrelated to hormones. Tricky shit here.
 
Ahh I see. No. She takes it before bed.

I will say that since switching to the patch, she seems to have a bit more energy. Maybe it's too early to judge. Her anxiety is still out of control but that could be unrelated to hormones. Tricky shit here.
If you draw blood 2-4 hours after taking P (absorption is massively increased when taken with fat). You would see a much higher number


Taking P with lower E levels can increase depression and anxiety in many women.


When did her anxiety start or worsen?
 
If you draw blood 2-4 hours after taking P (absorption is massively increased when taken with fat). You would see a much higher number


Taking P with lower E levels can increase depression and anxiety in many women.


When did her anxiety start or worsen?
Well... I have been with her for 18 years and can't really recall her ever without anxiety. 😂 I have a hard time pinpointing a worsening of it.

This is her busy season and anxiety naturally follows, but it does seem worse than usual. Probably no coincidence that on this latest blood draw, e2 has been at its lowest levels since beginning HRT, and P levels have been the highest.
 
HRT is bioidentical to our own E and T. The pregnancy E levels more than cover what happens when E is elevated to extremely high levels for a very long time (with T and P also being proportionately higher than non pregnancy levels)

We seem to be avoiding that MANY studies show unopposed estrogen increase risk cancer significantly. Why I mentioned people should look to receive bi-est. e2/e3. Is your office the one that made women sterile with T treatment?
 
We seem to be avoiding that MANY studies show unopposed estrogen increase risk cancer significantly. Why I mentioned people should look to receive bi-est. e2/e3. Is your office the one that made women sterile with T treatment?

You can't sterilize women with testosterone, that's absurd. The same mechanism would mean that all women on birth control are sterilized, LMFAO (Also that link is ridiculous "prevent endometrial cancer by giving synthetic manmade progestin, but sorry, that leads to increased breast cancer risk ").


I'm also not saying " don't take progesterone ever" but some women feel their best without progesterone and taking testosterone has an "opposing" effect on cancers that grow from estrogens (the few links i posted and there are more studies).


Hormonal birth control works via suppression of LH/FSH, which means ovulation is PAUSED. No egg gets released = woman does not get pregnant. In some rare cases, a woman cannot conceive after many years of birth control, but as i said above, this is a chicken or the egg, we don't know if that same person would be having fertility issues without ever having used HRT. Fertility problems are very very common nowadays.


A woman on T dose high enough to stop menstrual cycle for HRT; the above would apply^
 
Minor update: the patch is making a big difference for her. She's got more energy, laughing and smiling more, and getting horny. I think this is still early; we will be getting her T tested and find out where the E2 levels land soon.

For the record, the whole uterus and everything was removed due to family history of cancer.
 
Minor update: the patch is making a big difference for her. She's got more energy, laughing and smiling more, and getting horny. I think this is still early; we will be getting her T tested and find out where the E2 levels land soon.

For the record, the whole uterus and everything was removed due to family history of cancer.

There you go, usually, patient will feel temporary relief because the body is so sensitive to the hormone, but that's a honey moon phase (as seen with TRT), it's very likely it will not last, but it's a good thing that she has seen a glimpse of the benefits of HRT. She can feel that way all the time if she gets optimized.
 
There you go, usually, patient will feel temporary relief because the body is so sensitive to the hormone, but that's a honey moon phase (as seen with TRT), it's very likely it will not last, but it's a good thing that she has seen a glimpse of the benefits of HRT. She can feel that way all the time if she gets optimized.
Cool. I am going to have to explore the HRT clinics out there. You aware of one that does well with women?

Thanks for all your input, by the way.
 
Cool. I am going to have to explore the HRT clinics out there. You aware of one that does well with women?

Thanks for all your input, by the way.


Last i checked, Defy had injections for T and E for women as an option. Glad to help, always.
 

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