Intranasal drug delivery via hormones has been around for years. The efficacious of systemic drug delivery is near a 100% with most people. Very short duration, needs to be dosed several times throughout the day to reap any benefits.
Years ago Patrick Arnold made an intranasal androstenedione/diol. Not sure what he used as a carrier, although I remember very well it left a very "gummy" residue, making it very difficult to clean out of your nose without pulling all your nose hairs out! I used it a few times pre-work. Didn't particularly care for it, ended up throwing several bottles away.