Hello,
I am on finasteride to prevent hairloss and I need to taken aromatase inhibitor to reduce estrogen so was thinking of taking them together.
But I've just come across this study
Effect of dual inhibition of 5-alpha-reductase and aromatase on spontaneously developed canine prostatic hypertrophy. - PubMed - NCBI
"In the 5RI group, a significant decrease in the serum dihydrotestosterone (DHT) level was found, and prostatic volume was significantly decreased. However, significant increases in serum testosterone (T) and DHT levels were observed, with a concomitant increase in prostatic volume in the 5RI + ARI combination group. Morphometric analysis showed that histopathological findings in the 5RI + ARI combination group were similar to those in the BPH control group."
This study is pretty much saying with Fin + Aromatase inhibitor will return DHT levels to baseline. How is this even possible. Finasteride binds to the 5AR-2 enzymes and so it can't convert T->DHT. If there are only a limited number of 5AR-2 enzymes left after taking finasteride how is possible to get baseline levels of DHT?
Anyone who has knowledge on this, please chime in thanks
I am on finasteride to prevent hairloss and I need to taken aromatase inhibitor to reduce estrogen so was thinking of taking them together.
But I've just come across this study
Effect of dual inhibition of 5-alpha-reductase and aromatase on spontaneously developed canine prostatic hypertrophy. - PubMed - NCBI
"In the 5RI group, a significant decrease in the serum dihydrotestosterone (DHT) level was found, and prostatic volume was significantly decreased. However, significant increases in serum testosterone (T) and DHT levels were observed, with a concomitant increase in prostatic volume in the 5RI + ARI combination group. Morphometric analysis showed that histopathological findings in the 5RI + ARI combination group were similar to those in the BPH control group."
This study is pretty much saying with Fin + Aromatase inhibitor will return DHT levels to baseline. How is this even possible. Finasteride binds to the 5AR-2 enzymes and so it can't convert T->DHT. If there are only a limited number of 5AR-2 enzymes left after taking finasteride how is possible to get baseline levels of DHT?
Anyone who has knowledge on this, please chime in thanks