Finerenone - an additional heart and kidney protective medication

[Jose1990]

Current studies have elucidated interest on Finerenone as an additional medication that can be used for heart and kidney protective measures in us, PED users.

Unlike spirolactone which interacts with androgen and prolactin receptors, Fineronone acts only on mineral corticoid receptors. This could be a particularly interesting medication for those that run tren.

I’ve implemented at the initial dose of 10mg along side the trifecta of arb, nebivolol and jardiance in hoped that I can mitigate issues with my heart from using gear.

Just opening the topic for discussion.

A brief summary of clinical trials for your review:

Key Finerenone Clinical Trial Findings

• FINE-ONE Trial (Type 1 Diabetes & CKD): Found in 2025 that finerenone significantly reduced the urine albumin-to-creatinine ratio (UACR) by 25% over six months compared to placebo, showing safety consistent with T2D trials.
• FIND-CKD Trial (Non-Diabetic CKD): Reported in March 2026 that finerenone met its primary endpoint, significantly delaying kidney disease progression compared to placebo in patients with non-diabetic chronic kidney disease.
• FINEARTS-HF Trial (Heart Failure): Indicated that finerenone reduced the rate of composite outcomes (worsening heart failure events and cardiovascular death) in patients with mildly reduced or preserved ejection fraction.
• FIDELIO-DKD & FIGARO-DKD (T2D & CKD): These landmark Phase 3 trials showed a reduced risk of chronic kidney disease progression and cardiovascular events (e.g., hospitalization for heart failure).
• Safety Profile: Across studies, the most common adverse event of special interest is hyperkalemia (high potassium), though treatment discontinuation rates for this remain relatively low (1.7% in FINE-ONE).
  

 

[SouthernMuscle]

So many words yet you didn’t even say what class of drug it is or what the mechanism of action is or what it does besides some interaction with the MR

Lay off the AI

 

[specter]

So many words yet you didn’t even say what class of drug it is or what the mechanism of action is or what it does besides some interaction with the MR

Lay off the AI

And interacts with the androgen receptor, so blocking my steroids from being picked up..

 

[Jose1990]

So many words yet you didn’t even say what class of drug it is or what the mechanism of action is or what it does besides some interaction with the MR

Lay off the AI

non-steroidal, mineralocorticoid receptor antagonist (MRA) used to reduce the risk of kidney function decline, kidney failure, cardiovascular death

 

[Jose1990]

And interacts with the androgen receptor, so blocking my steroids from being picked up..

It doesn't. Re-read.

 

[specter]

It doesn't. Re-read.

im a dumb ass read way to fast

 

[Jose1990]

@bbxtreme Please chime in when you can.

I'm opening the topic for discussion.

It's currently being used in heart failure with preserved ejection fraction. It reduces inflammation and fibrosis in the heart (2 things that steroids cause in the heart through various mechanisms including calcium influx).

It's used to reverse/remodel the heart.

 

[specter]

Just readong a bit here and it deff looks interesting, i reclaim my fast response and i need to slow down my reading this early in the day

 

[SouthernMuscle]

non-steroidal, mineralocorticoid receptor antagonist (MRA) used to reduce the risk of kidney function decline, kidney failure, cardiovascular death

DIURETIC

How is that so difficult to say

 

[bbxtreme]

@bbxtreme Please chime in when you can.

I'm opening the topic for discussion.

It's currently being used in heart failure with preserved ejection fraction. It reduces inflammation and fibrosis in the heart (2 things that steroids cause in the heart through various mechanisms including calcium influx).

It's used to reverse/remodel the heart.

Finerenone isn’t a bodybuilding drug and it’s not a true diuretic. It’s an organ-protection med that reduces fibrosis and inflammation in the kidneys and heart. You’re usually seeing it in guys who’ve been pushing size and drugs for years and are starting to show early stress on labs. That’s seen through protein in the urine, rising creatinine, declining eGFR, or long-standing high blood pressure.

A lot of bodybuilders do end up there from long-term PED use, but it’s not something you run on cycle to “prevent” damage. It doesn’t fix the main drivers anyway. The real risks from gear are unmanaged blood pressure, hematocrit, lipids, insulin resistance, and bodyweight. That’s where the focus should be.

It also carries its own risk, mainly elevated potassium, so using it without a reason can create new problems, especially if you’re on an ARB as most bodybuilders are.

You asked me to chime in so I did, but I can’t say that everyone needs to go jump on this as it’s an “after the fact” med, not a preventative one from my perspective.

 

[whacked]

Good stuff BBX. Thank you

 

[Jose1990]

DIURETIC

How is that so difficult to say

It's not a diuretic despite its diuretic effects, your lack of intellectual capacity is greater than your ego.

 

[Jose1990]

Finerenone isn’t a bodybuilding drug and it’s not a true diuretic. It’s an organ-protection med that reduces fibrosis and inflammation in the kidneys and heart. You’re usually seeing it in guys who’ve been pushing size and drugs for years and are starting to show early stress on labs. That’s seen through protein in the urine, rising creatinine, declining eGFR, or long-standing high blood pressure.

A lot of bodybuilders do end up there from long-term PED use, but it’s not something you run on cycle to “prevent” damage. It doesn’t fix the main drivers anyway. The real risks from gear are unmanaged blood pressure, hematocrit, lipids, insulin resistance, and bodyweight. That’s where the focus should be.

It also carries its own risk, mainly elevated potassium, so using it without a reason can create new problems, especially if you’re on an ARB as most bodybuilders are.

You asked me to chime in so I did, but I can’t say that everyone needs to go jump on this as it’s an “after the fact” med, not a preventative one from my perspective.

Thanks for chiming in, good to see your perspective.

It's being used in Brazil as preventative measures in some bodybuilders, thats why I brought it up. I know a couple of olympians and pros on it.

 

[bbxtreme]

Thanks for chiming in, good to see your perspective.

It's being used in Brazil as preventative measures in some bodybuilders, thats why I brought it up. I know a couple of olympians and pros on it.

I would just be afraid of Hyperkalemia and a drop in kidney filtration which would show as a dip in eGFR and creatinine rise on labs. BP could also drop lower than anticipated for those on ARB’s and ACE Inhibitors.

Again, if they already have damage then sure it makes sense, which they may have at that level. But it’s certainly not going to substitute for foundational things like keeping BP in check. It’s an intervention, not a prevention.

 

[SouthernMuscle]

It's not a diuretic despite its diuretic effects, your lack of intellectual capacity is greater than your ego.

Ok genius.

Oh yes BRAZIL, hub of medical advancement that.

 

[Stewie]

So you've implemented this as an adjuvant to your prophylactic polypharmacy as it is to potentially stave off HF and/or CKD. Got it.

Not that it really matters, although whatever AI model you used(?) It hallucinated erroneously. Spironolactone doesn't have any meaningful impact on prolactin receptor activity. If you have anything that validates that it does– I'm all ears.

I'll refrain from contextualizing a long-winded dissertation on the potential of microsomal cytochrome isoenzymes interactions with the chemical warfare you're taking. I will advise this. If you're headstrong in running this combination of drugs – indulge and digest every other supplement, foods or drugs you are or may consider taking that are either a substrate, inducer or inhibitor of CYP3A4. There's a lot.

You gotta love the health community folks. They love extrapolating literature from diseased individuals– bringing it forth in the PED community. Sounds logical. Till you fuck yourself up.

 

[SouthernMuscle]

either a substrate, inducer or inhibitor of CYP3A4. There's a lot.

What about the compounds that are both substrate and inducer lol
Found that out when I started armodafinil

Very complex system. I’ve not even scratched the surface and it’s tons of info

 

[Stewie]

What about the compounds that are both substrate and inducer lol
Found that out when I started armodafinil

Very complex system. I’ve not even scratched the surface and it’s tons of info

Then we have the pharmacogenomic interindividual unknowns if you have any CYP3A4 SNP variants. This paints a totally different picture.

Nobody does genotyping?! I have a little bit, years ago. Aging and epigenetics may have flipped a switch towards a different metabolic pathway that I'm not aware of? I don't dabble anymore, so I'm golden. I think

 

[SouthernMuscle]

Then we have the pharmacogenomic interindividual unknowns if you have any CYP3A4 SNP variants. This paints a totally different picture.

Nobody does genotyping?! I have a little bit, years ago. Aging and epigenetics may have flipped a switch towards a different metabolic pathway that I'm not aware of? I don't dabble anymore, so I'm golden. I think

This is quickly getting to a level above my pay grade

I do understand the basic premise of epigenetics and find it extremely interesting. Especially the concept of epigenetic inheritance

 

[specter]

This is quickly getting to a level above my pay grade

I do understand the basic premise of epigenetics and find it extremely interesting. Especially the concept of epigenetic inheritance

I love that they are look into the whole "genetic reaction to drugs" so in the future a quick blood test can tell wich way to go when you get into the hospital drug wise.