In my 60's. Been on 30 years, probably more, losing my memory, just kidding.
I did everything wrong for years. I have severe heart disease in my family. Killed my father and my older brother. 16 years ago, I had a heart attack and bi-pass surgery. My doctor told me that my heart was big and strong like the rest of me. He said whatever I've been doing saved my life. He said a weaker man would not have survived. He told me HRT was extremely healthy for me. He said my body and my cardiovascular system was of a man 25 years younger. He said honestly, but don't quote him, my lifestyle of strength training, high protein, cardio (never did enough till recently) and adding a reasonable amount of testosterone made me a great example of health and fitness. He said without my lifestyle I'd be dead for 20 years already.
I'm a little different because I've been a full-time trainer for 30 years, competed in power for 22 years. So, I'm in the gym 7 days a week. Basically, NEVER miss a workout!!!!
My point is I have some sore joints but, I'm the healthiest I've ever been. BTW my sex drive is over the top!! LOL
Just be smart with anabolics.