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- Jun 17, 2002
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Has anyone looked into Fucoxanthin? The info on it and results from human trials are quite remarkable. It raises metabolic rate without raising heart rate. It's an uncoupler like DNP it seems.
Fucoxanthin is a carotenoid derived from a special seaweed that has been extensively studied for its antioxidant powers. Animal studies have demonstrated its beneficial effects in stroke prevention, reduction of inflammation, and slowing the growth of various cancer cell types.
Sorry for any formatting issues. Copying this on my phone:
Impressive Human Studies
But what about fucoxanthin in humans? While research is in its early stages, evidence suggests that when humans supplement with fucoxanthin, they may induce the expression of UCP1 in their stores of white fat, just as the animals did in the Japanese studies.24-28 In the words of one researcher, this makes fucoxanthin an attractive new target for “pharmacological management of complex pathological syndromes such as obesity, type 2 diabetes or chronic inflammatory diseases.”27
Impressive Human Studies
Two groups of researchers are leading the way by studying how fucoxanthin supplements affect fat stores in human subjects. These studies are so recent that they haven’t yet even appeared in print, but we were given the opportunity to review the completed data analyses and report some of the most exciting results here.
The first study was aimed at determining the effects of fucoxanthin supplements, in combination with pomegranate seed oil, on energy expenditure rate in obese, non-diabetic female volunteers.28 Subjects ingested supplements before meals daily for 16 weeks, and all participants were placed on a controlled 1,800-calorie/day diet. Their energy expenditure rate (how much energy their bodies produced over time) was measured using a standard procedure known as indirect calorimetry.
The results were nothing short of astonishing—subjects who took fucoxanthin plus pomegranate seed oil generated greater absolute increases in energy expenditure. These researchers concluded that the combination of fucoxanthin and pomegranate seed oil can significantly increase metabolism and could well have profound anti-obesity properties.
That conclusion was put to the test by the second research group, who studied the impact of the fuco-xanthin-pomegranate seed oil combination on body weight, body and liver fat content, and a variety of plasma risk factor markers in a group of obese, non-diabetic women.18,28,29 The 110 subjects in this placebo-controlled study were randomized into two groups who received the following:
either 200 mg of a proprietary extract that included marine vegetable standardized for fucoxanthin, fucoxanthinol, omega-3 fatty acids, and pomegranate seed oil high in punicic acid or
200 mg placebo.Treatment was given in both groups 15-30 minutes before meals three times per day for 16 weeks in conjunction with an 1,800-calorie/day diet.
Outstanding Results
Sit down for these results—they are stunning. After six weeks on the supplements, there was a statistically significant reduction in body weight in the supplemented group who had normal liver fat content, and by eight weeks the fatty-liver group was also showing significant weight loss, compared with placebo.
By the end of the 16-week study, women with fatty livers had lost an average of more than 15 pounds, compared with just three pounds in their placebo-supplemented peers!
The normal liver-fat group had similar results, losing an average of nearly 14 pounds, compared with just over three pounds in the placebo group.29 In other words, both active groups lost just under a pound a week over the entire study period, which is a healthy, sustainable, and realistic rate of weight loss.
Outstanding Results
Weight loss alone is not the only or even the best marker of improvement in the risks posed by fat. Supplemented patients in this study also demonstrated a significant reduction in visceral fat. Visceral fat is the type of fat that covers the organs of the abdominal cavity like the liver.
No patient in this study reported any side effects. Please note that pomegranate seed oil contains different constituents and functions differently in the body than pomegranate juice extracts.
There are tons of things on Google about it but the info here is from LEF: Safely Burn Away Body Fat - Life Extension
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I just picked up a bottle from Amazon. From my research it seems it can take 4-6 weeks for it to really kick and and should be taken 15+ min before meals. I've seen dosing of 1 to 2 200mg caps 3 times a day.
It seems like a VERY interesting compound and curious if others know much about this stuff or used it.
Sent from my SM-N900V using Tapatalk 2
Fucoxanthin is a carotenoid derived from a special seaweed that has been extensively studied for its antioxidant powers. Animal studies have demonstrated its beneficial effects in stroke prevention, reduction of inflammation, and slowing the growth of various cancer cell types.
Sorry for any formatting issues. Copying this on my phone:
Impressive Human Studies
But what about fucoxanthin in humans? While research is in its early stages, evidence suggests that when humans supplement with fucoxanthin, they may induce the expression of UCP1 in their stores of white fat, just as the animals did in the Japanese studies.24-28 In the words of one researcher, this makes fucoxanthin an attractive new target for “pharmacological management of complex pathological syndromes such as obesity, type 2 diabetes or chronic inflammatory diseases.”27
Impressive Human Studies
Two groups of researchers are leading the way by studying how fucoxanthin supplements affect fat stores in human subjects. These studies are so recent that they haven’t yet even appeared in print, but we were given the opportunity to review the completed data analyses and report some of the most exciting results here.
The first study was aimed at determining the effects of fucoxanthin supplements, in combination with pomegranate seed oil, on energy expenditure rate in obese, non-diabetic female volunteers.28 Subjects ingested supplements before meals daily for 16 weeks, and all participants were placed on a controlled 1,800-calorie/day diet. Their energy expenditure rate (how much energy their bodies produced over time) was measured using a standard procedure known as indirect calorimetry.
The results were nothing short of astonishing—subjects who took fucoxanthin plus pomegranate seed oil generated greater absolute increases in energy expenditure. These researchers concluded that the combination of fucoxanthin and pomegranate seed oil can significantly increase metabolism and could well have profound anti-obesity properties.
That conclusion was put to the test by the second research group, who studied the impact of the fuco-xanthin-pomegranate seed oil combination on body weight, body and liver fat content, and a variety of plasma risk factor markers in a group of obese, non-diabetic women.18,28,29 The 110 subjects in this placebo-controlled study were randomized into two groups who received the following:
either 200 mg of a proprietary extract that included marine vegetable standardized for fucoxanthin, fucoxanthinol, omega-3 fatty acids, and pomegranate seed oil high in punicic acid or
200 mg placebo.Treatment was given in both groups 15-30 minutes before meals three times per day for 16 weeks in conjunction with an 1,800-calorie/day diet.
Outstanding Results
Sit down for these results—they are stunning. After six weeks on the supplements, there was a statistically significant reduction in body weight in the supplemented group who had normal liver fat content, and by eight weeks the fatty-liver group was also showing significant weight loss, compared with placebo.
By the end of the 16-week study, women with fatty livers had lost an average of more than 15 pounds, compared with just three pounds in their placebo-supplemented peers!
The normal liver-fat group had similar results, losing an average of nearly 14 pounds, compared with just over three pounds in the placebo group.29 In other words, both active groups lost just under a pound a week over the entire study period, which is a healthy, sustainable, and realistic rate of weight loss.
Outstanding Results
Weight loss alone is not the only or even the best marker of improvement in the risks posed by fat. Supplemented patients in this study also demonstrated a significant reduction in visceral fat. Visceral fat is the type of fat that covers the organs of the abdominal cavity like the liver.
No patient in this study reported any side effects. Please note that pomegranate seed oil contains different constituents and functions differently in the body than pomegranate juice extracts.
There are tons of things on Google about it but the info here is from LEF: Safely Burn Away Body Fat - Life Extension
-------------
I just picked up a bottle from Amazon. From my research it seems it can take 4-6 weeks for it to really kick and and should be taken 15+ min before meals. I've seen dosing of 1 to 2 200mg caps 3 times a day.
It seems like a VERY interesting compound and curious if others know much about this stuff or used it.
Sent from my SM-N900V using Tapatalk 2
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