Generic tirzaptide legit but not working

[Massive G]

I don't trust it solely on the basis of it being mass marketed so intensely and at such a large scale by big pharma.

I'm a resident physician currently and just yesterday I heard an obesity fellow (someone in the process of specializing in obesity medicine after their 3 year residency) talking about how they are currently researching monoclonal antibodies to combat the muscle loss from glp1s and how "maybe this will help my patients who all have the sunken face look from sarcopenia".

Quickly googling it seems glp1s actually decrease protein synthesis through actual mechanisms interacting specifically to decrease protein synthesis, as in not just the normally expected consequence of having people lose muscle from losing weight.

I don't care to look into the specifics more because I've made up my mind that I'm not touching them as of now and for at least many years to come, so knowing more details don't affect me one way or the other. Just wanted to say it's not as straightforward as it seems. To your face doctors will tell you it's safe and no major side effects blah blah blah. Behind your back they will talk about "all" (yes most likely not literal) of their glp1 patients having visible sarcopenia and researching new drugs to combat the side effect of this drug which will undoubtedly wind up causing more sjde effects...

So personally I am not touching the shit with a 10 foot pole, until we have something that is more important than big pharma "data", which is real life experience after many years particularly in bodybuilders.

I have been in the pharmaceutical industry for 30 years. Each decade seems to find a new block buster treatment for some medical issue created by bad diets and chemicals in our food and environment. 1990s through 2000 saw an explosion of anti depressants. 2000s were all about the new disease type 2 diabetes. Thrown in the painkillers in this time as well. The glps are now the new holy grail. I feel they have some use in people that have no choice anymore however I feel doses are way too high and cause horrible side effects. But they make more money on higher doses. There are many people that won't take them because of their food addiction. I have talked to many people at work that are on them and they just don't enjoy eating anymore. Also several report severe effects of being wiped out for 2 to 3 days after their weekly dose.
I am going to continue to microdose retatrutide at .10 mg EOD for the anti inflammatory benefits. At that low dose no sides and better BG control more energy etc.
Not trying to get anyone to use these just trying to use in a smart safe way .

 

[liquid_c]

I have been in the pharmaceutical industry for 30 years. Each decade seems to find a new block buster treatment for some medical issue created by bad diets and chemicals in our food and environment. 1990s through 2000 saw an explosion of anti depressants. 2000s were all about the new disease type 2 diabetes. Thrown in the painkillers in this time as well. The glps are now the new holy grail. I feel they have some use in people that have no choice anymore however I feel doses are way too high and cause horrible side effects. But they make more money on higher doses. There are many people that won't take them because of their food addiction. I have talked to many people at work that are on them and they just don't enjoy eating anymore. Also several report severe effects of being wiped out for 2 to 3 days after their weekly dose.
I am going to continue to microdose retatrutide at .10 mg EOD for the anti inflammatory benefits. At that low dose no sides and better BG control more energy etc.
Not trying to get anyone to use these just trying to use in a smart safe way .

I'm not sure about the high dose thing. The 2.5mg dose of Mounjaro is literally the exact same price as the 15mg version at any pharmacy.

 

[KillerStack]

I see your side but picture this...the laziest person you know who can't even keep a job. A pill is developed for him, he takes it. Few weeks after taking it his physique blows yours away..he did nothing to achieve it and you have busted your ass for years, he did nothing.

GLPs are here to make weight loss possible without self control...but where do you personally draw the line? As science invents more drugs like this...eventually dedication won't be needed for anything. One day we will click.on an app and choose our body...Brad pitt in fight club? Jay cutler? Take your pick just hit a button, no gym, no diet. Obviously that's extreme and laughable but I'm sure with gene therapy and genetic modifications one day people will come out of the womb looking perfect..no variation..no obesity..no gums..etc.

I know the mindset exactly. "You should earn it." However reality doesn't care about some subjective ideals. Mentzer was a fool on many things but he said it's stupid to waste your life training endlessly in some dungeon if you don't have to, there's no inherent value in that, and I agree. Unless that is very fulfilling to you personally, go right ahead, but as a general ideal it doesn't make much sense to suffer needlessly imo.

I've argued, lol, for decades on bodybuilding forums that the only thing that will have an impact on obesity in a free society of abundance is drugs and "science." Not any willpower coaching or similar. And I always get a ton of pushback from even PED users for some reason. "We need more drugs, not less, as well as better drugs" I say to piss people off further or maybe make them think but people lose their shit lol.

People will adjust eventually. It's like with AI, things will change and some will resist but what can you do about "progress"?

 

[FrancisK]

What? What does your wife have to do with any thing ? That’s weird for you to even mention your wife . Why are you quoting what I said when other people on this forum have literally said the same thing ? Seems like your picking on me because I’m new here

His wife is obviously using a GLP so you called her a "fat fuck with no will power".

There are numerous people on this board using them, so they are all "fat fucks with no will power"?

Playing victim after you were the one running your mouth is cute....

Some would say steroids are for lazy fucks with no work ethic. Do you use steroids?

 

[liquid_c]

His wife is obviously using a GLP so you called her a "fat fuck with no will power".

There are numerous people on this board using them, so they are all "fat fucks with no will power"?

Playing victim after you were the one running your mouth is cute....

Some would say steroids are for lazy fucks with no work ethic. Do you use steroids?

That is why I could never hate on anyone using a GLP-1. With all I have taken for muscle building, that would personally make me a huge hypocrite. Plus a lot of people are using them now for the other metabolic benefits vs the weight loss itself. Overall most people seem to have to reported overall positive benefits with GLP-1's. It at the end of the day is still just a tool in the toolbox.

 

[qbkilla]

That is why I could never hate on anyone using a GLP-1. With all I have taken for muscle building, that would personally make me a huge hypocrite. Plus a lot of people are using them now for the other metabolic benefits vs the weight loss itself. Overall most people seem to have to reported overall positive benefits with GLP-1's. It at the end of the day is still just a tool in the toolbox.

I see what your saying about being a hypocrite although it's not an exact comparison because aas aren't using punishment (the proper behavior term) to change body composition they are using positive reinforcement which actually leads to long term behavior change.

 

[Massive G]

I'm not sure about the high dose thing. The 2.5mg dose of Mounjaro is literally the exact same price as the 15mg version at any pharmacy.

That's the starting dose. They ramp up pretty high over 4 week increments.
So it just goes to show that the drug is way overpriced if what you say is true.

 

[Aikman56]

Not every doctor tows the big pharma line.
Plenty of non network doctors in private practice that don't write scripts based on the pretty pharm girl sales rep in high heels.

That stereotype is LONG diminished.
Since the mid 2000s (when the opioid mess was uncovered) pharmaceutical companies have have done a lot of policing themselves (ourselves) in addition to government guidelines.
The days of playing it fast and loose with indications and paying docs to write are (for most companies) gone.

I have been in the industry for 21 years and have worked in specialties ranging from infectious disease to urology to gastroenterology to critical care to dermatology to my current specialty of ophthalmology and I have worked FOR every size of company from start-ups to mom-and-pop manufacturers to monster organizations like Johnson & Johnson and currently Alcon, and there’s been a huge shift since the early-2000s.

I’ve personally seen many reps fired for getting caught just TALKING off label. We’re held to strict spending limits for educational lunches ($25/ person, and the staff member must be patient-facing). Docs can’t bring spouses to educational lectures. And gifts? Annually, I’m allowed to gift a textbook to the doctor IF it relates to his or her specialty.

Oh, and reps? Typically troglodytes like myself, middle-aged moms (most all of us with science degrees or clinical experience) and the OCCASIONAL young, pretty female. In companies I’ve worked for, I can count on two hands the number of attractive women that I’ve seen carrying a bag in the last ten years, and maybe a few added on to that that I’ve seen with other companies…and most of those were in cosmetic dermatology/ plastic surgery sales)!

Sure, I can imagine that there’s still some tomfoolery about, and there’s the occasional hottie bending over to pick up a pen in front of the docs, but it’s nothing like people think, and 180° from what it once was.

These days, the corruption comes largely from Medicare, Medicaid, and large government contracts (like the “solution” to the unnamed virus of unknown origin… but we’re not getting into politics!).

 

[FakeName123]

These days, the corruption comes largely from Medicare, Medicaid, and large government contracts (like the “solution” to the unnamed virus of unknown origin… but we’re not getting into politics!).

Wasn't gonna bring it up myself but basically this. When was the last and probably only time in history where something from big pharma was pushed this heavily? I'll leave it at that, lol

 

[gib68sg]

Wasn't gonna bring it up myself but basically this. When was the last and probably only time in history where something from big pharma was pushed this heavily? I'll leave it at that, lol

When was the last time a drug was invented that was legitimately life changing with little to no immediate side effects?

 

[drafty_c]

GLP-1s really pulled back the curtain on a lot of modern health hypocrisy. Love 'em or hate 'em, they’re changing the game.

 

[cage99]

The same people that will hate on GLP-1’s have no problems using AAS to alter their bodies to gain muscle. Take assloads of pills that strain their livers, raise their blood pressure which strains their kidneys, and increase bad cholesterol. Also, they’ll pump several iu’s of growth to help add lean mass and trim up. They’ll use multiple forms of fat burners from ECA, DNP, clenbuterol to T3/T4 to speed up fat loss.

It’s mind boggling where some people draw their line in the sand and say nope that’s cheating. I had to struggle to get mine, you didn’t, so that’s the wrong way. I don’t give two shits what someone else ingests, injects, etc. because it doesn’t affect me one bit. Why it bothers some people I have no f’n clue!

As to the OP I’d switch to Semaglutide if you wanna feel something from these GLP’s.

Cage

 

[xpoc]

Glp is invented for fat fucks with no will power to diet

I think it was invented for diabetics.

 

[xpoc]

The same people that will hate on GLP-1’s have no problems using AAS to alter their bodies to gain muscle. Take assloads of pills that strain their livers, raise their blood pressure which strains their kidneys, and increase bad cholesterol. Also, they’ll pump several iu’s of growth to help add lean mass and trim up. They’ll use multiple forms of fat burners from ECA, DNP, clenbuterol to T3/T4 to speed up fat loss.

It’s mind boggling where some people draw their line in the sand and say nope that’s cheating. I had to struggle to get mine, you didn’t, so that’s the wrong way. I don’t give two shits what someone else ingests, injects, etc. because it doesn’t affect me one bit. Why it bothers some people I have no f’n clue!

As to the OP I’d switch to Semaglutide if you wanna feel something from these GLP’s.

Cage

Agree:

Most appetite suppression= semaglutide
Some appetite suppression plus probability to maintain muscle mass= tirzepatide
Little appetite suppression plus speeding up metabolism and possibility of gaining muscle= retatrutide

Ever study has proven that Reta is superior for weight loss compared to the other 2.