GH on 2 yrs. NOW coming OFF an it's HARD !!

YANKEES1 · Mar 22, 2013

Been on 5-8 iu's a day for a good yr. an half. Sometimes doing 10 iu from time to time. First got GREAT GAINS . Weight is staying steady maybe few lbs of water. Ok problem started when could NOT ejaculate during sex with my girl. Turns out SERATONIN level was extreamly HIGH . So started to lower down when I crashed . So now taking a Seratonin replacement . I guess that was the sense of well being , while on GH. Down to 2 iu's a day . My ejaculating is getting better. But the crash was VERY HARD. Can anyone relate to what I went through ? Have a specialist advising me. Said could tske up to 1 yr. before sex life is NORMSl .. Because could NOT keep my eyes open . I think I stayed on a little to long .. Thanks for any advice. If taken at 3 iu's a day . Think it's a GREAT supplement :banghead:

jm425 · Mar 22, 2013

Highly doubt prolonged gh use caused your ejaculation problems. Probably something else you are/were on. It's good to take a short break gh every 6 months. Run peps or igf instead for 6-8 weeks.

jm425 · Mar 22, 2013

There is a correlation between gh and serotonin, but it's insignificant according to scientific studies based on animals.

Mattia386 · Mar 22, 2013

Never had a problem Not ejaculating but it did take a lot longer which was probably a good thing, dont wanna be a 2 pump chump. I ran seronos for a little over a year but took a break every few months to run Igf. Just started cjc dac and ghrp. Well see how that goes.

aduren · Mar 25, 2013

Never heard of that. If the serotonin levels would be affected that much studies on elderly men and hgh would have showed it.

It is weird indeed, were you on anything else?

YANKEES1 · Mar 25, 2013

aduren said:
Never heard of that. If the serotonin levels would be affected that much studies on elderly men and hgh would have showed it.

It is weird indeed, were you on anything else?

No just HRT (Test) .. One time my levels came back so I high they asked if I was on anti Depessants . An the answer was NO . So if your serotonin levels come back high . And you are not on an anti-depressant.. It could be there is a tumor in your body.. So I went through this three hour test that they shoot you with radioactive stuff so it goes through out your body . An a scan runs over ur body real slow. Well came back NEGATIVE . I asked the Dr. I was on GH an he said that could raise your Serotonin levels. An to stop immediately , ahh there was no way I was gonna stop just yet. Since test came back negative .. Strange I'm the only one , this has happened to . I have since lowered my IU's to three a day Max and my sex life is much better.. Lol

aduren · Mar 25, 2013

YANKEES1 said:
No just HRT (Test) .. One time my levels came back so I high they asked if I was on anti Depessants . An the answer was NO . So if your serotonin levels come back high . And you are not on an anti-depressant.. It could be there is a tumor in your body.. So I went through this three hour test that they shoot you with radioactive stuff so it goes through out your body . An a scan runs over ur body real slow. Well came back NEGATIVE . I asked the Dr. I was on GH an he said that could raise your Serotonin levels. An to stop immediately , ahh there was no way I was gonna stop just yet. Since test came back negative .. Strange I'm the only one , this has happened to . I have since lowered my IU's to three a day Max and my sex life is much better.. Lol

So, maybe you are more sensitive, and running those doses for a year of no rest kept your body in a positive feedback loop with serotonin. I would like to know what your levels are now that you went down in dosis.

"Inhibition of Hypoglycemia-Induced Growth Hormone Secretion by the Serotonin Antagonists Cyproheptadine and Methysergide

Carl H. Bivens, M.D., Harold E. Lebovitz, M.D., and Jerome M. Feldman, M.D.

N Engl J Med 1973; 289:236-239August 2, 1973DOI: 10.1056/NEJM197308022890503
Share:
Abstract

Growth hormone secretion is provoked by hypoglycemia. Since hypothalamic serotonin content increases during insulin-induced hypoglycemia, the role of hypothalamic serotonin in growth hormone secretion in man was examined. Hypoglycemia-induced growth hormone release in normal volunteers was studied during a control period and after two days of administration of serotonin antagonists, cyproheptadine and methysergide. Plasma growth hormone was measured by radioimmunoassay, and total growth hormone secretion was expressed as the area under the growth hormone curve from 0 to 120 minutes. Cyproheptadine administration resulted in a 59 per cent reduction (p<0.01), and methysergide in a 35 per cent reduction (p<0.05) in growth hormone secretion. The decrease in plasma glucose during the control and treatment periods indicated a comparable stimulus for growth hormone release in both study groups. If these drugs act by antagonizing serotonin, as assumed, this study suggests that serotonin is involved in hypoglycemia-induced growth hormone release. (N Engl J Med 289:236–239, 1973)"

YANKEES1 · Mar 25, 2013

aduren said:
So, maybe you are more sensitive, and running those doses for a year of no rest kept your body in a positive feedback loop with serotonin. I would like to know what your levels are now that you went down in dosis.

"Inhibition of Hypoglycemia-Induced Growth Hormone Secretion by the Serotonin Antagonists Cyproheptadine and Methysergide

Carl H. Bivens, M.D., Harold E. Lebovitz, M.D., and Jerome M. Feldman, M.D.

N Engl J Med 1973; 289:236-239August 2, 1973DOI: 10.1056/NEJM197308022890503
Share:
Abstract

Growth hormone secretion is provoked by hypoglycemia. Since hypothalamic serotonin content increases during insulin-induced hypoglycemia, the role of hypothalamic serotonin in growth hormone secretion in man was examined. Hypoglycemia-induced growth hormone release in normal volunteers was studied during a control period and after two days of administration of serotonin antagonists, cyproheptadine and methysergide. Plasma growth hormone was measured by radioimmunoassay, and total growth hormone secretion was expressed as the area under the growth hormone curve from 0 to 120 minutes. Cyproheptadine administration resulted in a 59 per cent reduction (p<0.01), and methysergide in a 35 per cent reduction (p<0.05) in growth hormone secretion. The decrease in plasma glucose during the control and treatment periods indicated a comparable stimulus for growth hormone release in both study groups. If these drugs act by antagonizing serotonin, as assumed, this study suggests that serotonin is involved in hypoglycemia-induced growth hormone release. (N Engl J Med 289:236–239, 1973)"

I'm going for blood work next week will post . As soon as results come in . Thank you for this , so it is possible in some cases . As of right now I was at 8 iu's a day minimum upwards of 10 iu's an it was close to 2 yrs. but just started at about 1yr. 6 months . So today I am lowerd to 3 iu's a day with 50 mg of Amtriptalyn . This came as a suggestion of a expert in this field. Who did endless research of MY !! CASE !! . As it states your Serotonin Is induced by the hypoglycemia . So I would suggest it be wise NOT to go for so long.. Just trying to help someone else from enduring this. Like I said thank you my friend and I will get back with my results ASAP

conzboneeus · Mar 25, 2013

Good idea as someone said to take a short break from GH every 6 months or so. I am taking week of this week been on 6 months seeing fat loss now. Since I am gonna hit it hard next 3 months figured I'd break now and then get busy.

I've had ejaculation issue also for along time. More likely something other than AAS causing it. On the plus side I can go for a long time and the ladies don't seem to mind that at all. Look it that way! :headbang:

thehazzle · Mar 25, 2013

Maybe look into peptides instead?

aduren · Mar 27, 2013

YANKEES1 said:
I'm going for blood work next week will post . As soon as results come in . Thank you for this , so it is possible in some cases . As of right now I was at 8 iu's a day minimum upwards of 10 iu's an it was close to 2 yrs. but just started at about 1yr. 6 months . So today I am lowerd to 3 iu's a day with 50 mg of Amtriptalyn . This came as a suggestion of a expert in this field. Who did endless research of MY !! CASE !! . As it states your Serotonin Is induced by the hypoglycemia . So I would suggest it be wise NOT to go for so long.. Just trying to help someone else from enduring this. Like I said thank you my friend and I will get back with my results ASAP

I mostly do research in mice but when you sit a look at the growth axis started either by exercise of GH it is a literal cascade of hormones from gh to igf1, igf2, mechano growth factor etc etc. Serotonin is a mother load of reactions. Since any synthethic aid will throw natural body regulation mechanism (mostly negative) it is only fair our body will keep trying to downregulate whatever we are using in excess. The increase gh--> hypoglacemia only increased the production of serotonin.

I do think you will return to baseline soon. The medicine you were given is strong, will help with serotonin uptake. Besides hormones my expertise does not go that far. But comparing serotonin levels will go a long way in seeing the correlation between ius and its levels.

YANKEES1 · Mar 27, 2013

aduren said:
I mostly do research in mice but when you sit a look at the growth axis started either by exercise of GH it is a literal cascade of hormones from gh to igf1, igf2, mechano growth factor etc etc. Serotonin is a mother load of reactions. Since any synthethic aid will throw natural body regulation mechanism (mostly negative) it is only fair our body will keep trying to downregulate whatever we are using in excess. The increase gh--> hypoglacemia only increased the production of serotonin.

I do think you will return to baseline soon. The medicine you were given is strong, will help with serotonin uptake. Besides hormones my expertise does not go that far. But comparing serotonin levels will go a long way in seeing the correlation between ius and its levels.

Thank You my friend , like I said I will get Seratonin levels from when they thought I had a tumor . An the results from this Tuesdays physical . I told my Dr. Already an hrs gonna get other from gastrologist .. If in anyway I can help in ur research I will .. Thank you for making realize I'm NOT the only one this can happen to. I have off of work soon for a month that is when I will be dropped to 1ius an then OFF !! I will post as I go to help you. I'm a BIG mouse !! An u can document my strides along the way. Which some have NOT been FUN !! But I'm stable with the 50mg of Amtriptalyn an 3 iu's . In a couple weeks will lower to 2 iu's . Then 1 iu an OFF . K . My friend Thank You again. And you have any questions just ask !!

aduren · Mar 27, 2013

YANKEES1 said:
Thank You my friend , like I said I will get Seratonin levels from when they thought I had a tumor . An the results from this Tuesdays physical . I told my Dr. Already an hrs gonna get other from gastrologist .. If in anyway I can help in ur research I will .. Thank you for making realize I'm NOT the only one this can happen to. I have off of work soon for a month that is when I will be dropped to 1ius an then OFF !! I will post as I go to help you. I'm a BIG mouse !! An u can document my strides along the way. Which some have NOT been FUN !! But I'm stable with the 50mg of Amtriptalyn an 3 iu's . In a couple weeks will lower to 2 iu's . Then 1 iu an OFF . K . My friend Thank You again. And you have any questions just ask !!

What are your blood results as of today/recently? testosterone and full metabolic? I am assuming they did those exams already. I often like to see vitamin D and B12 absorption.

Did you stay constant with the same brand of gh or did you often change it?

Just keep me updated. You will need consistent blood measurements to see once you come off if your body adjusting accordingly. 1 test before you quit, 1 test 1 week after you quit and then every 2 weeks.

My hope is you will kick back right away to normal levels, but it is better to make sure it does happens rather than estimate.

surfbh · Mar 29, 2013

I'd look deeply into cabergoline. It raises dopamine as well as serotonin. Also lowers prolactin which gh raises. And prolactin causes many a broke dick.

Rlhammer · Mar 29, 2013

enlarged prostate

FireRoss · Mar 29, 2013

surfbh said:
I'd look deeply into cabergoline. It raises dopamine as well as serotonin. Also lowers prolactin which gh raises. And prolactin causes many a broke dick.

I was about to say this as well. Prolactin will kill not only your sex drive but your performance as well. It's naturally secreted after a man has an orgasm, and that is about the only time a man isn't looking for sex.

Try caber for two weeks, problem solved.

bignic123 · Apr 2, 2013

Gh

I actcually think its the test the u were on probally not coming off properly over time and not the gh

YANKEES1 · Apr 3, 2013

bignic123 said:
I actcually think its the test the u were on probally not coming off properly over time and not the gh

First my Dr. Cancelled my appt. had a seminar to attend. So new appt is in 10 days.

An NO NOT the TEST I am HRT . So that basically says I'm a lifer . LOL.. Thank you for your input..

3rd what an where do you get carber ?? NEVER heard of this , I'll Goggle it Thank You.