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- Aug 15, 2006
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What is the optimal dose for GHRP-2 if only injecting once a day on a 5on 2off schedule. Can it be reconstituted with B-12?
Last edited:
Grasshoper,
This info should help. This was published by the man himself Datbtrue. You can also get info on the GHRPs on the first page of the thread.
Hexarelin is very much on topic in the sense that it is one of the growth hormone releasing peptides (GHRPs).
By GHRP I mean a synthetic form of Ghrelin (w/o the negative aspects) capable of binding to the GH-receptor and stimulating GHRH release in the hypothalamus, inhibiting Somatostatin (at both the hypo & pit) & having some direct effects of GH release directly in the pituitary.
All the GHRPs act the same way and create a GH pulse, synergistically so w/ GHRH (CJC-1295).
The literature pretty much treats them all the same.
The differences are:
POTENCY:
Ipamorelin is potent but the weakest GH releaser.
GHRP-6 is very potent in effecting GH release.
GHRP-2 is a little bit more potent then GHRP-6
Hexarelin, the strongest is a little more potent then GHRP-2.
CORTISOL & PROLACTIN:
Ipamorelin does not increase cortisol or prolactin at any dose.
GHRP-6 dose not effect these hormones up to 100mcg but does so minimally above 100mcg.
GHRP-2 has a stronger effect on these hormones at all dosing levels rising to the high normal range for cortisol & prolactin.
Hexarelin at all dosing levels has the strongest impact on cortisol & prolactin with levels in the upper bounds of normalcy.
DESENSITIZATION:
Ipamorelin & GHRP-6 do not desensitize as long as there are short breaks between doses (i.e. 2 hours or so).
GHRP-2 does not desensitize in the lower dose ranges w/ short breaks. At high dose it is unclear, but some desensitization may occur.
Hexarelin has been shown to desensitize w/o regard to dose and even with short breaks between doses. This effect shows up after 14 days of continuous use and may be avoided by either keeping doses low or taking a full day or two off every two weeks.
DOSES:
Saturation dose for all GHRPs is 100mcg or (1mg/kg).
Effective doses have been demonstrated that are lower (particularly if used w/ GHRH).
Higher than 100mcg may have an effect but only a fraction of the above 100mcg will be taken up by an available receptor.
The highest dose in the literature beyond which there was zero benefit is 400mcg.
* Effective of dose is measure by the amount of GH released in plasma as a result. It is not a measure of side-effects or intensity of hunger.
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SO what would any benefit be using ghrp2 over ghrp6. Seems like ghrp2 has sides and ghrp6 doesnt unless dosed really high.
SO what would any benefit be using ghrp2 over ghrp6. Seems like ghrp2 has sides and ghrp6 doesnt unless dosed really high.
im taking sermorelin 500mcgs twice a day, can and how would i encorperrate ghrp-2 with it, when and at what dose