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(Warning, this is unedited and kind of stream-of-consciousness thoughts on the subject written at 1:30 am...)
GLP-1 Agonists and why we Gym Rats Might be Interested
GLP-1 (Glucagon-like peptide) is a strange bird. It has a very short half-life of 2 minutes in the body and while it increases insulin secretion it also slows gastric emptying. Someone asked me recently if it would make a good replacement for insulin as used by bodybuilders. And, the short answer to that is no. Since it slows gastric emptying there'd be no call for using it as you would humalog or humalin-r pre or post workout. The carbs, aminos, creatine etc. just wouldn't get into the system fast enough to work their magic as they do with regular insulin. But, a better explanation is that it would be to insulin as a good PCT is to a heavy steroid cycle. I'll get into that in a minute. Plus, because of its short half-life it is basically useless in and of itself. What we want is a good GLP-1 "agonist" and that's where exenatide comes in.
Exenatide (trade name Byetta) was discovered in the saliva of gila monsters and is actually found concentrated in the tails. Hence the slang term for it "lizard spit!" lol. It only shares a 50% identical amino acid sequence to GLP-1 thus making it an "agonist" or promoter of GLP-1 vs actually being a copy or analogue. The benefit to all this is that because of its structure it produces many of the same positive effects but is prevented by being broken down by GPP-4, the protein that is present throughout the body that destroys GLP-1, so quickly. Thus exenatide has a much longer half life and is injected only twice per day in a similar way that we use our GH secretogues: subcuteneous injections, 1 hr before a meal on an empty stomach.
Now, for a bodybuilder, what are the benefits of exenatide?
1) Induces Insulin secretion/Increases insulin sensitivity- This is important after a period of use of GH, insulin, IGF-1, steroids etc. All which tend to decrease insulin sensitivity over time. Think about it: When we come off a long steroid cycle we use something to get the "boys" working again and the testosterone flowing. With insulin being the most anabolic of all hormones shouldn't we also seek to maximize our own natural production and sensitivity?
2) Slows gastric emptying- This happens because of exenatide's ability to block glucagon release. Hence, we get a sense of being fuller, longer. And, essentially we are. This is the value we derive from eating whole wheat products vs high glycemic white bread. With a slower release of nutrients into the system we get a less "jagged" insulin spike = less carbs stored as fat! But, with the effect of increased insulin sensitivity, our bodies make better use of what glucose is in the system, i.e. makes us more "efficient" at using what we eat! A word of caution here. Since exenatide slows gastric emptying, it should never, ever be used in direct conjunction (at the same time) with insulin. While you are trying to get those carbs into your system to prevent a blood glucose crash, exenetide will be slowing down the release of those nutrients in your gut! Big trouble potential!!
With these two properties, exenatide appears to be a great product for use during a pre-contest diet that includes, and especially one that cycles, carbs. Since its effects are glucose dependent (i.e. the more carbs you eat, the more insulin is released) you will likely be able to tolerate more carbs while dieting than before while yet remaining insulin sensitive and putting them to use- though I, obviously, wouldn't try to eat more carbs than you need in this situation. In various trials people lost an average of 7 lbs over the course of some 26 weeks. But, these were average schlubs, not bodybuilders actually trying to burn fat and using other supplements along the way. Combining exenatide with a little bit of t-3 and a healthy dose of test might be a great combo while tackling a tough contest diet. Just a thought.
So, if you want to maximize insulin sensitivity and carb utilization, exenatide may be an interesting option at some point. Though it wouldn't be an ideal candidate for bulking/gaining cycles (the slow gastric emptying will make you actually want to eat less), it may be just what the doctor ordered while trimming off excess fat after a bulk cycle. The usual peptide side-effect of occasional nausea was reported (though I'm used to that with mt2 and other peps). But, for the most part it has been well tolerated and would seem to be, overall, a "healthy" drug as it evens out blood glucose spikes and tends to help trim the waistline.
I haven't tried it yet. But, when I get the chance I'm gonna give it a go just based on the little bit of research I've done. Go out and google it. Read about other options for these benefits and I'll think you'll see why I'm talking about this drug. It's a kind of "middle of the road" thing: it's more powerful/effective than metformin but with much, much less risk of going hypoglycemic as you might with actual insulin. The half-life is much longer than GLP-1 but shorter than a couple other GLP-1 analogues that are in the works. These analogues often last for a day and some for up to ten days! No thanks, I'd like to have a bit more control over what my system is doing. i.e. if I wanted to have some insulin pre-workout, I still could with exenatide. I'd just schedule doses far enough away that they didn't overlap in any way- exenatide 7 am, humalog 4 pm pre workout, exenatide 8:30 pm... or something like that.. Not recomending that, but I'd just rather have some control and know it'd be out of my system in a matter of hours vs. days.
Ok, I'm rambling now. These are just some thoughts. Like I say, check it out for yourself, lots of info out there on this and other interesting peptides of this sort.
GLP-1 Agonists and why we Gym Rats Might be Interested
GLP-1 (Glucagon-like peptide) is a strange bird. It has a very short half-life of 2 minutes in the body and while it increases insulin secretion it also slows gastric emptying. Someone asked me recently if it would make a good replacement for insulin as used by bodybuilders. And, the short answer to that is no. Since it slows gastric emptying there'd be no call for using it as you would humalog or humalin-r pre or post workout. The carbs, aminos, creatine etc. just wouldn't get into the system fast enough to work their magic as they do with regular insulin. But, a better explanation is that it would be to insulin as a good PCT is to a heavy steroid cycle. I'll get into that in a minute. Plus, because of its short half-life it is basically useless in and of itself. What we want is a good GLP-1 "agonist" and that's where exenatide comes in.
Exenatide (trade name Byetta) was discovered in the saliva of gila monsters and is actually found concentrated in the tails. Hence the slang term for it "lizard spit!" lol. It only shares a 50% identical amino acid sequence to GLP-1 thus making it an "agonist" or promoter of GLP-1 vs actually being a copy or analogue. The benefit to all this is that because of its structure it produces many of the same positive effects but is prevented by being broken down by GPP-4, the protein that is present throughout the body that destroys GLP-1, so quickly. Thus exenatide has a much longer half life and is injected only twice per day in a similar way that we use our GH secretogues: subcuteneous injections, 1 hr before a meal on an empty stomach.
Now, for a bodybuilder, what are the benefits of exenatide?
1) Induces Insulin secretion/Increases insulin sensitivity- This is important after a period of use of GH, insulin, IGF-1, steroids etc. All which tend to decrease insulin sensitivity over time. Think about it: When we come off a long steroid cycle we use something to get the "boys" working again and the testosterone flowing. With insulin being the most anabolic of all hormones shouldn't we also seek to maximize our own natural production and sensitivity?
2) Slows gastric emptying- This happens because of exenatide's ability to block glucagon release. Hence, we get a sense of being fuller, longer. And, essentially we are. This is the value we derive from eating whole wheat products vs high glycemic white bread. With a slower release of nutrients into the system we get a less "jagged" insulin spike = less carbs stored as fat! But, with the effect of increased insulin sensitivity, our bodies make better use of what glucose is in the system, i.e. makes us more "efficient" at using what we eat! A word of caution here. Since exenatide slows gastric emptying, it should never, ever be used in direct conjunction (at the same time) with insulin. While you are trying to get those carbs into your system to prevent a blood glucose crash, exenetide will be slowing down the release of those nutrients in your gut! Big trouble potential!!
With these two properties, exenatide appears to be a great product for use during a pre-contest diet that includes, and especially one that cycles, carbs. Since its effects are glucose dependent (i.e. the more carbs you eat, the more insulin is released) you will likely be able to tolerate more carbs while dieting than before while yet remaining insulin sensitive and putting them to use- though I, obviously, wouldn't try to eat more carbs than you need in this situation. In various trials people lost an average of 7 lbs over the course of some 26 weeks. But, these were average schlubs, not bodybuilders actually trying to burn fat and using other supplements along the way. Combining exenatide with a little bit of t-3 and a healthy dose of test might be a great combo while tackling a tough contest diet. Just a thought.
So, if you want to maximize insulin sensitivity and carb utilization, exenatide may be an interesting option at some point. Though it wouldn't be an ideal candidate for bulking/gaining cycles (the slow gastric emptying will make you actually want to eat less), it may be just what the doctor ordered while trimming off excess fat after a bulk cycle. The usual peptide side-effect of occasional nausea was reported (though I'm used to that with mt2 and other peps). But, for the most part it has been well tolerated and would seem to be, overall, a "healthy" drug as it evens out blood glucose spikes and tends to help trim the waistline.
I haven't tried it yet. But, when I get the chance I'm gonna give it a go just based on the little bit of research I've done. Go out and google it. Read about other options for these benefits and I'll think you'll see why I'm talking about this drug. It's a kind of "middle of the road" thing: it's more powerful/effective than metformin but with much, much less risk of going hypoglycemic as you might with actual insulin. The half-life is much longer than GLP-1 but shorter than a couple other GLP-1 analogues that are in the works. These analogues often last for a day and some for up to ten days! No thanks, I'd like to have a bit more control over what my system is doing. i.e. if I wanted to have some insulin pre-workout, I still could with exenatide. I'd just schedule doses far enough away that they didn't overlap in any way- exenatide 7 am, humalog 4 pm pre workout, exenatide 8:30 pm... or something like that.. Not recomending that, but I'd just rather have some control and know it'd be out of my system in a matter of hours vs. days.
Ok, I'm rambling now. These are just some thoughts. Like I say, check it out for yourself, lots of info out there on this and other interesting peptides of this sort.
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