GLP1 and thyroid cancer risk.

[TODouble2]

I’ve seen the warnings about family history of thyroid cancer and using GLP1s. It specifies the risk is with medullary thyroid cancer history. I have a family history of papillary thyroid cancer. Would you think there’s any concern for me being it’s a different type?


Also, I’ve attached a study below that showed no increased cancer risk overall, or even specific.

Tirzepatide and Cancer Risk in Individuals with and without Diabetes: A Systematic Review and Meta-Analysis - PubMed

Tirzepatide use in RCTs over 26 to 72 weeks did not increase overall or specific cancer risk.

pubmed.ncbi.nlm.nih.gov

 

[qbkilla]

I'm no doctor but I personally wouldn't risk it. What can you achieve with these new drugs that you can't without? Is the "reward " worth the risk?

 

[Stewie]

There's distinctive differences between cell types. The simplified differences. Accordingly, GLP-1r (receptors) don't take up residence in follicular cells, this cell type is what gives rise to papillary thyroid cancer. Unlike parafollicular cells (C-cells), this cell type purportedly GLP-1r do take up residence. Which allegedly gives rise to medullary thyroid cancer. This is why it's not recommended to use a GLP-1ra with a family history of -MTC- medullary thyroid cancer.

Given the single differences (there's other differences), this would not change my mind if there's a family history of -PTC - papillary thyroid cancer. Cells can act very aberrantly (abnormally) through paracrine cell-cell communication. Even though there's no documentation (to the best of my understanding) of PTC with GLP-1ra usage. I'd hate to be that one in a bazillion chances of a rouge cell-cell miscommunication.

My daughter had hurthle cell carcinoma, another type of thyroid cancer. She was asking my thoughts if Ozempic would open the floodgates of reoccurrence. Accordingly to the brain-trust, there's no increased risk. My answer to her, is the same I would suggest to you. Nota-fuk-n chance should you take it.

 

[xpoc]

I’ve seen the warnings about family history of thyroid cancer and using GLP1s. It specifies the risk is with medullary thyroid cancer history. I have a family history of papillary thyroid cancer. Would you think there’s any concern for me being it’s a different type?


Also, I’ve attached a study below that showed no increased cancer risk overall, or even specific.

Tirzepatide and Cancer Risk in Individuals with and without Diabetes: A Systematic Review and Meta-Analysis - PubMed

Tirzepatide use in RCTs over 26 to 72 weeks did not increase overall or specific cancer risk.

pubmed.ncbi.nlm.nih.gov

Conclusion: Tirzepatide use in RCTs over 26 to 72 weeks did not increase overall or specific cancer risk.

I am not sure if you are looking for reassurance from the msg board bros, but the conclusion of the study does not leave a lot of room for interpretation.

 

[Stewie]

Conclusion: Tirzepatide use in RCTs over 26 to 72 weeks did not increase overall or specific cancer risk.

I am not sure if you are looking for reassurance from the msg board bros, but the conclusion of the study does not leave a lot of room for interpretation.

It can take up to a decade for MTC to show up on imaging.

What is the most important information I should know about ZEPBOUND?
ZEPBOUND may cause serious side effects, including:
• Possible thyroid tumors, including cancer. Tell your healthcare provider if you get a lump or swelling in your
neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies
with rats, ZEPBOUND and medicines that work like ZEPBOUND caused thyroid tumors, including thyroid cancer. It
is not known if ZEPBOUND will cause thyroid tumors, or a type of thyroid cancer called medullary thyroid carcinoma
(MTC) in people.

• Do not use ZEPBOUND if you or any of your family have ever had a type of thyroid cancer called MTC, or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

https://www.google.com/url?sa=t&source=web&rct=j&opi=89978449&url=https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/217806s000lbl.pdf&ved=2ahUKEwjAyJnA0rqMAxWgF2IAHe1UNrYQFnoECCgQAQ&usg=AOvVaw13N1NsiTC_1bPOfssnnSC0

 

[xpoc]

This article from Healthline explains it well IMO: https://www.healthline.com/health-news/ways-ozempic-wegovy-improve-health#Heart-attack-and-stroke

 

[Stewie]

This article from Healthline explains it well IMO: https://www.healthline.com/health-news/ways-ozempic-wegovy-improve-health#Heart-attack-and-stroke

The citation I posted is the black box warning placed on the prescription pamphlets.

In that particular citation you shared from Healthline doesn't mention anything about a family history of medullary thyroid cancer/ multiple endocrine neoplasia s2. It briefly mentions colon cancer.

If there's a relative risk with a family history, and you're comfortable knowing there's a greater risk than the general population. As small as it may be, go for it.

As useless as I find using Healthline as a source of credibility. Its like citing Wikipedia.

This is from a different Healthline article:

"One downside, however, is that they have not been recommended for use in those with a personal or family history of either medullary thyroid cancer or multiple endocrine neoplasia.

Previous studies, starting with rodent studies conducted in the premarketing phase, have raised concerns about whether GLP-1 receptor agonists could increase a person’s risk for cancer.

In response, these medications have been required to carry a black box warning regarding the potential risk.

However, a new studyTrusted Source published on April 10, 2024, in BMJ indicates these concerns may be unfounded.

According to this study, treatment with GLP-1 receptor agonists was not linked with any substantial increase in risk for thyroid cancer in people who were followed up on average for 3.9 years.

The study authors did acknowledge that a small increase in risk could not be ruled out, but it would be no greater than a 31% increase in relative risk.

In other words, no more than 0.36 excess cancers per 10,000 person-years would occur compared to the background incidence of 1.46 per 10,000 person-years in those who had used a different type of diabetes medication."

Ozempic: GLP-1 Drugs Unlikely to Increase Thyroid Cancer Risk

New research suggests that GLP-1 drugs like Ozempic and Wegovy are not likely to increase the risk of thyroid cancer.

www.healthline.com

 

[TODouble2]

The citation I posted is the black box warning placed on the prescription pamphlets.

In that particular citation you shared from Healthline doesn't mention anything about a family history of medullary thyroid cancer/ multiple endocrine neoplasia s2. It briefly mentions colon cancer.

If there's a relative risk with a family history, and you're comfortable knowing there's a greater risk than the general population. As small as it may be, go for it.

As useless as I find using Healthline as a source of credibility. Its like citing Wikipedia.

This is from a different Healthline article:

"One downside, however, is that they have not been recommended for use in those with a personal or family history of either medullary thyroid cancer or multiple endocrine neoplasia.

Previous studies, starting with rodent studies conducted in the premarketing phase, have raised concerns about whether GLP-1 receptor agonists could increase a person’s risk for cancer.

In response, these medications have been required to carry a black box warning regarding the potential risk.

However, a new studyTrusted Source published on April 10, 2024, in BMJ indicates these concerns may be unfounded.

According to this study, treatment with GLP-1 receptor agonists was not linked with any substantial increase in risk for thyroid cancer in people who were followed up on average for 3.9 years.

The study authors did acknowledge that a small increase in risk could not be ruled out, but it would be no greater than a 31% increase in relative risk.

In other words, no more than 0.36 excess cancers per 10,000 person-years would occur compared to the background incidence of 1.46 per 10,000 person-years in those who had used a different type of diabetes medication."

Ozempic: GLP-1 Drugs Unlikely to Increase Thyroid Cancer Risk

New research suggests that GLP-1 drugs like Ozempic and Wegovy are not likely to increase the risk of thyroid cancer.

www.healthline.com

I appreciated your input, it’s all just so confusing. I had no intention of staying on this long term, and def not going up high in dosage. I thought I was in the clear since they specified that specific type of thyroid cancer which was not the one my mother had.

From what I’ve seen, the warnings seemed to be for people taking them for over a year. I could see great benefit utilizing this stuff for only a few months at a time, at 2.5mg. I see no point in raising it.

I know it’s stupid to risk it, but holy shit is this drug what I’ve been missing. I’ve always suffered with not being able to go to sleep without having a full belly and some kind of sweets. I wake up in the middle of the night and eat cookies and go back to bed. That can’t be healthy.

I’ve been on tirz for 5 weeks and have never been able to eat like this in my life. Im down a little over 20 pounds and its completely changed my relationship with food. I’ve always used drugs to compensate for my shit diet, and that along with high BP lead to severe heart failure. This drug instead of compensating for the bad diet, actually fixed my eating habits.

Ive read lots of obese people lost weight and stopped taking it and actually kept weight off which is promising.

 

[qbkilla]

[QUOTE="TODouble2, post: 3496254, member: I’ve always used drugs to compensate for my shit diet, and that along with high BP lead to severe heart failure. This drug instead of compensating for the bad diet, actually fixed my eating habits.
[/QUOTE]

I wouldn’t say the drug has fixed your eating habits. Your in the same situation, you are relying on a drug because you don't have the discipline not to eat shit.

 

[TODouble2]

[QUOTE="TODouble2, post: 3496254, member: I’ve always used drugs to compensate for my shit diet, and that along with high BP lead to severe heart failure. This drug instead of compensating for the bad diet, actually fixed my eating habits.

I wouldn’t say the drug has fixed your eating habits. Your in the same situation, you are relying on a drug because you don't have the discipline not to eat shit.
[/QUOTE]

You are correct, but the other way I was using things like tren, t3, ephedrine, etc.. but still eating like shit. This way I actually am eating better. Call it what you want. I literally can’t sleep on an empty stomach, I practically sleep walk in the middle of the night to snack. I’m 40 years old and I’ve been this way my whole life.

I rely on drugs for my blood pressure, heart failure, etc…. But this one thing is so wrong? You use steroids right? Would you be the same size without them? You rely on them to be larger that you can without them. People love to point fingers when it comes to diet and will power. I’m not a morbidly obese person, but I also clearly have issues when it comes to food. And most of the population does for that matter. I applaud and respect you guys who can diet like that, I truly do.

 

[qbkilla]

I wouldn’t say the drug has fixed your eating habits. Your in the same situation, you are relying on a drug because you don't have the discipline not to eat shit.

You are correct, but the other way I was using things like tren, t3, ephedrine, etc.. but still eating like shit. This way I actually am eating better. Call it what you want. I literally can’t sleep on an empty stomach, I practically sleep walk in the middle of the night to snack. I’m 40 years old and I’ve been this way my whole life.

I rely on drugs for my blood pressure, heart failure, etc…. But this one thing is so wrong? You use steroids right? Would you be the same size without them? You rely on them to be larger that you can without them. People love to point fingers when it comes to diet and will power. I’m not a morbidly obese person, but I also clearly have issues when it comes to food. And most of the population does for that matter. I applaud and respect you guys who can diet like that, I truly do.
[/QUOTE]

I love to eat too but rather than glp there are other ways to feel full without the junk. Example intermittent fasting. Food choices that fill you up before bed...steak omelette, veggies, cottage cheese, etc. Just my personal opinion I don't think glp are fixing poor dietary habits or the miracle people are making them out to be.

 

[TODouble2]

You are correct, but the other way I was using things like tren, t3, ephedrine, etc.. but still eating like shit. This way I actually am eating better. Call it what you want. I literally can’t sleep on an empty stomach, I practically sleep walk in the middle of the night to snack. I’m 40 years old and I’ve been this way my whole life.

I rely on drugs for my blood pressure, heart failure, etc…. But this one thing is so wrong? You use steroids right? Would you be the same size without them? You rely on them to be larger that you can without them. People love to point fingers when it comes to diet and will power. I’m not a morbidly obese person, but I also clearly have issues when it comes to food. And most of the population does for that matter. I applaud and respect you guys who can diet like that, I truly do.

I love to eat too but rather than glp there are other ways to feel full without the junk. Example intermittent fasting. Food choices that fill you up before bed...steak omelette, veggies, cottage cheese, etc. Just my personal opinion I don't think glp are fixing poor dietary habits or the miracle people are making them out to be.
[/QUOTE]

I’m hoping they don’t have a very dark side yet to be discovered.. but if not, then I feel they are that miracle.. nevermind us on this forum, think of all the countless obese people who have had dramatic weight loss. Normally it would take gastric bypass surgery for them to accomplish that. And like I said I’ve seen a lot of them reporting coming off the drug and maintaining a healthy lifestyle. My father in law is a type 2 diabetic. He wasn’t huge or anything but he started these meds prob 6-7 years ago for diabetes dropped about 50 pounds and has kept it off.

I wish we could flip a switch and somehow fix obesity without a drug, but it is what it is. Especially in America we are a very unhealthy country.

 

[bbxtreme]

I appreciated your input, it’s all just so confusing. I had no intention of staying on this long term, and def not going up high in dosage. I thought I was in the clear since they specified that specific type of thyroid cancer which was not the one my mother had.

From what I’ve seen, the warnings seemed to be for people taking them for over a year. I could see great benefit utilizing this stuff for only a few months at a time, at 2.5mg. I see no point in raising it.

I know it’s stupid to risk it, but holy shit is this drug what I’ve been missing. I’ve always suffered with not being able to go to sleep without having a full belly and some kind of sweets. I wake up in the middle of the night and eat cookies and go back to bed. That can’t be healthy.

I’ve been on tirz for 5 weeks and have never been able to eat like this in my life. Im down a little over 20 pounds and its completely changed my relationship with food. I’ve always used drugs to compensate for my shit diet, and that along with high BP lead to severe heart failure. This drug instead of compensating for the bad diet, actually fixed my eating habits.

Ive read lots of obese people lost weight and stopped taking it and actually kept weight off which is promising.

I tell people who are in similar situations that it’s really a simple equation.

If you’re not willing to fix your lifestyle and eating habits (what you should do) then which risk is greater of causing a health event first?

Shitty diet and excess body fat or the GLP. Both of these will have risk. We know for certain what shitty diet and lifestyle will cause. We don’t know long term what the GLP will cause. They’re too new.

Nobody can answer the question but you as its risk vs outcome. I’m a calculated risk taker, not a gambler. But 90% of the time people in your shoes will opt for the GLP and make it a potential future self problem.

Maybe the median compromise is to use as little of the GLP as possible to create new lifestyle and dietary patterns and behaviors. Then discontinue it. But in the case of potential cancer is it really even worth the unknown risk…

 

[xpoc]

The citation I posted is the black box warning placed on the prescription pamphlets.

In that particular citation you shared from Healthline doesn't mention anything about a family history of medullary thyroid cancer/ multiple endocrine neoplasia s2. It briefly mentions colon cancer.

If there's a relative risk with a family history, and you're comfortable knowing there's a greater risk than the general population. As small as it may be, go for it.

As useless as I find using Healthline as a source of credibility. Its like citing Wikipedia.

This is from a different Healthline article:

"One downside, however, is that they have not been recommended for use in those with a personal or family history of either medullary thyroid cancer or multiple endocrine neoplasia.

Previous studies, starting with rodent studies conducted in the premarketing phase, have raised concerns about whether GLP-1 receptor agonists could increase a person’s risk for cancer.

In response, these medications have been required to carry a black box warning regarding the potential risk.

However, a new studyTrusted Source published on April 10, 2024, in BMJ indicates these concerns may be unfounded.

According to this study, treatment with GLP-1 receptor agonists was not linked with any substantial increase in risk for thyroid cancer in people who were followed up on average for 3.9 years.

The study authors did acknowledge that a small increase in risk could not be ruled out, but it would be no greater than a 31% increase in relative risk.

In other words, no more than 0.36 excess cancers per 10,000 person-years would occur compared to the background incidence of 1.46 per 10,000 person-years in those who had used a different type of diabetes medication."

Ozempic: GLP-1 Drugs Unlikely to Increase Thyroid Cancer Risk

New research suggests that GLP-1 drugs like Ozempic and Wegovy are not likely to increase the risk of thyroid cancer.

www.healthline.com

Stewie, if you have any reservations I would not use it. No different than anabolics or HGH. If you have reservations, better to take a pass.

 

[TODouble2]

I tell people who are in similar situations that it’s really a simple equation.

If you’re not willing to fix your lifestyle and eating habits (what you should do) then which risk is greater of causing a health event first?

Shitty diet and excess body fat or the GLP. Both of these will have risk. We know for certain what shitty diet and lifestyle will cause. We don’t know long term what the GLP will cause. They’re too new.

Nobody can answer the question but you as its risk vs outcome. I’m a calculated risk taker, not a gambler. But 90% of the time people in your shoes will opt for the GLP and make it a potential future self problem.

Maybe the median compromise is to use as little of the GLP as possible to create new lifestyle and dietary patterns and behaviors. Then discontinue it. But in the case of potential cancer is it really even worth the unknown risk…

When I say shitty diet, I mean not a strict bodybuilding diet. It’s prob a bit better than most average Americans are eating. I try to get my protein in, but I eat sandwiches, eat out at restaurants a lot, and always need a muffin or something like that and a glass of milk before bed. it’s not like I’m eating potato chips and drinking soda all day. But as far as bodybuilding is concerned, it’s a shit diet. I love training, I’ll never stop, but I just never had it in me to stick to the diet..

I’ve been in pretty damn good shape before, not enough to step on a stage of course. I’m not comparing myself to you real bodybuilders at all. Maybe I’m overstating what I mean lol. I’m not a fat fuck I could just never get that fat layer from off my waist and see all my abs.

So I saw this as a way to stay lean and eat healthy at this point in life, since steroids are kind of off the table for me. My idea was similar to what you said. If I could maybe take this for two to three months leading into the summer I’d be content with that.

But obviously I’m even questioning that with the thyroid cancer risk, it’s just driving me nuts that they specified medullary only, which I don’t have family history of.

 

[bbxtreme]

When I say shitty diet, I mean not a strict bodybuilding diet. It’s prob a bit better than most average Americans are eating. I try to get my protein in, but I eat sandwiches, eat out at restaurants a lot, and always need a muffin or something like that and a glass of milk before bed. it’s not like I’m eating potato chips and drinking soda all day. But as far as bodybuilding is concerned, it’s a shit diet. I love training, I’ll never stop, but I just never had it in me to stick to the diet..

I’ve been in pretty damn good shape before, not enough to step on a stage of course. I’m not comparing myself to you real bodybuilders at all. Maybe I’m overstating what I mean lol. I’m not a fat fuck I could just never get that fat layer from off my waist and see all my abs.

So I saw this as a way to stay lean and eat healthy at this point in life, since steroids are kind of off the table for me. My idea was similar to what you said. If I could maybe take this for two to three months leading into the summer I’d be content with that.

But obviously I’m even questioning that with the thyroid cancer risk, it’s just driving me nuts that they specified medullary only, which I don’t have family history of.

To me it would not be worth it. We know a lot about GLP’s, but not enough long term IMO to take the risk. Especially now hearing your diet. Do more steps and cardio. Substitute milk for almond or oat milk. Simple things that go a long way. GLP’s are for obese people with no self control IMO. I’m not convinced they’re a cheat code for bodybuilders personally.

 

[xpoc]

Here is how I describe GLP's to the masses. Imagine you body is a computer. You are downloading porn, going to unsecure websites, and inviting viruses that slow down your system. You do a hard re-start (control+alt+delete) and you get to re-boot your system. Once you do, things speed back up and everything is working as it should be. IF you go back to the same activities, you'll end up in the same loop again.

With GLPs they are essentially a body restart (control+alt+delete). They will get you back to your fighting weight (cheat code). It will give you the opportunity for a "do-over" and start to eat well, monitor calories etc. After you stop taking them, if you go back to your same ways of eating junk, excessive calories etc, you'll end up in the same loop again.

For guys who are already lean and want to get shredded...well you get the best results because you are already disciplined and the GLP will help take you to that next level. If I was a competitor I don't see a scenario where I don't have this powerful fat burning tool in my toolbox.

 

[KingOfSushi]

I have a family history of papillary thyroid cancer. Would you think there’s any concern for me being it’s a different type?

The reality is none of us know for sure. We’d only be guessing.

 

[KingOfSushi]

[QUOTE="TODouble2, post: 3496254, member: I’ve always used drugs to compensate for my shit diet, and that along with high BP lead to severe heart failure. This drug instead of compensating for the bad diet, actually fixed my eating habits.

I wouldn’t say the drug has fixed your eating habits. Your in the same situation, you are relying on a drug because you don't have the discipline not to eat shit.
[/QUOTE]
If taking Telmi put your BP in range, you would say it fixed your blood pressure. See what I’m saying?

 

[qbkilla]

[/QUOTE]
If taking Telmi put your BP in range, you would say it fixed your blood pressure. See what I’m saying?
[/QUOTE]

Disagree. That's like saying someone has a weak grip that gives out on deadlifts so they use straps. They didn't fix their grip. Or has shoulder pain so takes decades to lift pain free, they didn't fix their shoulder they just masked the negativity affects.