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Glycine for better sleep.

What is your opinion of high dosed melatonin? Personally I couldn't get over the sleep issues it causes me, independent of dose.
High dose of melatonin is subjective to the individual’s overall health. There are some individuals with either bacterial or viral infections and those inflicted with different types of cancer dx that will dose upwards of 5 grams. I personally don't know anyone that takes that amount. Although if you have Facebook or X, you can follow Doris Loh and you'll see some of her followers discussing their dosages.

I personally take 48mg of sublingual nightly. If by chance I'm around someone that's symptomatic of a viral infection, I'll add in 100mg time released MEL alongside the 48mg sublingual. I started doing this when my youngest daughter was collecting spit samples on the campus at the UofI during C19.

Melatonin acts very multi-faceted. In regards to the arena that most play in around here. On what can we take that plays a pivotal role on skeletal muscle mitochondria stability-function. Melatonin plays an in-direct role in regulating phase separation, of the small-snippet of phase separation, this helps in cellular clean-up to set the stage for skeletal muscle mitochondria to convey energy sources to other subcellular organelles. This would be a minuscule role in the bigger picture.
 
yea i'm seeing that now, interesting. I don't know where i saw the max 10mg thing from.
Yeah man I have a baggie of melatonin powder from bulk sups and just take a tiny scoop. Used to weigh it but Gave up. Know the scoop ranges between 30-100mg. I just eyeball it. Dirt cheap. $15 for over 8,300 servings of 3mg. Basically 25g for $15
 
I added in Ashwagandha last night to my sleep stack and slept incredible. Coincidence or not, I’ll definitely be keeping it in—seemed to help a lot, had a lot of very deep, rem sleep

Stacking:
Ashwagandha
l theanine
Magnesium glycinate
Melatonin
 
36mg melatonin? I’m confused lol I thought melatonin was used at max 10mg.
I’ve gone up to 100mg-120mg with no adverse effects , just sometimes get wild vivid dreams

But then I’ll cycle off for a few weeks when tolerance builds that high, and start again at 20mg

Melatonin is safe, but I’d still use lowest possible dose
 
I think it's due to my neurotransmitter genetics.

I have a very flat dopamine response and metabolize it quickly (COMT DRD2, DRD4 variants, and Low MAOA activity) , keeping me very calm in most situations, regardless of androgens.
On the flip side, this also tends to make me slightly lethargic.

Shit where do i get this calmness and all these checked?
 
I added in Ashwagandha last night to my sleep stack and slept incredible. Coincidence or not, I’ll definitely be keeping it in—seemed to help a lot, had a lot of very deep, rem sleep

Stacking:
Ashwagandha
l theanine
Magnesium glycinate
Melatonin

Something I've never taken. May have to give a whirl.
 
Something I've never taken. May have to give a whirl.
The literature behind it is pretty solid, adds a nice calming sensation too, and the sleep quality seems to be better

But I need to run it longer to really have an opinion, one night isn’t really enough.

sleep was incredible last night though so it definitely didn’t hurt
 
Shit where do i get this calmness and all these checked?
Get your raw DNA data from one of the DNA testing companies then feed it to Promothease. Then take that and use ChatGPT to query and analyze the data.
 
Alot of guys with Animal (IDanimal) Been doing 50mgs melatonin at night for awhile ....he dug up quite a bit of info on stomach issues and and other health issues related to low melatonin levels in the stomach ,


Very helpful ! Did not add it last night but will tonight .
 
Alot of guys with Animal (IDanimal) Been doing 50mgs melatonin at night for awhile ....he dug up quite a bit of info on stomach issues and and other health issues related to low melatonin levels in the stomach ,


Very helpful ! Did not add it last night but will tonight .

Animal… as in animal the one and only?

What is there about atomach issues due to melatonin?

I searched on a website about what deficiencies one could have whilst on certain meds and it showed i was deficient in

Melatonin​

Summary: Melatonin concentrations were significantly suppressed by alprazolam at 23:00, midnight, 01:00, 06:00, and 07:00 h. A trend toward suppression was evident from 02:00 to 05:00 h. Cortisol concentrations were also suppressed by alprazolam at several times throughout the night (01:00-04:00 h).

Mytavin dot com
 
ashwaganda is next on my list. been hearing about it for years from various sources.
I already had for it reputation to stem cell production.

Last night didn't sleep as well .......BUT I don't think I took as much of each . Try again 2nite
 
This might be a stupid question and if so feel free to tell me but is magnesium glycinate the same or similar to glycine?
I haven't read the whole thing, but just in case, don't take too much magnesium for the glycine or you will regret it!
 
Ok uped it last night slept 4.5hrs . Do you guys take more if u wake up and want to try to get more sleep.
 

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