Grapefruit Juice And Meds

[Ashop]

Grapefruit and Medications May Be A Deadly Mix | Yahoo! Health

 

[nickels]

On the other hand, grapefruit juice with a benzo or some other med before going out for drinks makes for a cheap night.

 

[collinb]

I wasnt negatively effected by it I feel when I was taking GFJ with anavar or Tbol. I know it helped for sure, but didnt notice any negatives.

 

[nosnmiveins]

I've known that grapefruit juice enhances absorption of orals for a while, but just heard this morning on a local radio show how it can make meds (prescription) 5-6 times stronger and cause a lot of health issues.

 

[ManoftheWorld]

On the other hand, grapefruit juice with a benzo or some other med before going out for drinks makes for a cheap night.

I like to go big or go home so its at that point for me when the night really kicks up and things start to get interesting LOL

 

[theillest]

I eat ruby red grapefruit everyday. This is news to me.

 

[BigRick82]

Anytime I drink grapefruit juice it amplify's my reactions big time to benzo's.

 

[chemical engineer]

I second that on the benzos, but it also works well with fina. Been drinking grapefruit juice for the last month and the fro looks even thicker.

 

[magnus82]

Interesting info

Here’s what happens: Grapefruit contains furanocoumarins, which block an enzyme that normally breaks down certain medications in the body. When it is left unchecked, medication levels can grow toxic in the body.


This interaction can occur even if grapefruit is eaten many hours before taking the medication. For example, simvastatin, when taken with about a 7-ounce glass of grapefruit juice once a day for three days, produced a 330% greater concentration of the drug compared to taking it with water. This can cause life-threatening muscle damage called rhabdomyolysis.

“Grapefruit and grapefruit products may interact with a broad class of medications ranging from cardiovascular to hormonal drugs,” says Tara Narula, MD, the associate director of cardiac care at Lenox Hill Hospital in New York City. “Some have more of an effect if you take them in close proximity to drinking grapefruit juice than if you space it out, but there can still be an interaction if you take the pill the night before or 12 hours before consuming grapefruit or grapefruit juice.”

The researchers note that grapefruit interaction is specific to certain drugs and doesn’t necessarily affect an entire drug class.

 

[Ashop]

I've known that grapefruit juice enhances absorption of orals for a while, but just heard this morning on a local radio show how it can make meds (prescription) 5-6 times stronger and cause a lot of health issues.

There has been debate over this for years about it enhancing the strength of oral AAS.

 

[pintobean]

That Liver cytochrome P450 is a tricky pathway

 

[ManoftheWorld]

There has been debate over this for years about it enhancing the strength of oral AAS.

I think the main thing is regarding the oral bioavailability of the drug it self since some drugs have low or lower bioavailability than others, so the grapefruit for those would prob just maximize the bioavailability and absorption... for other drugs where their bioavailability is already high or max then what the grapefruit does is hinders them from being readily broken down which leave the various meds in the danger zone of being that 5-6x more potent cuz levels stay elevated for too long... and in the case of benzos they have a consistently high bioavailability amongst the various benzos available for the most part.. one in particular is versed.. orally is extremely low to result in much higher dose but when used IM/IV then a very little goes a long way to make you lights out LOL