Gut health supplements NOT peptides

[nothuman]

I don’t believe in a lot of gut health supplements due to lack of evidence. There is a lot more marketing hype in that category.

When it comes to the gut, a high fiber diet is priority 1, 2, and 3. High fiber is better than anything for the microbiome that we are aware of (feeds good gut bacteria, produces beneficial short chain fatty acids, improves gut barrier, etc)

Then we want to look at fermented foods, such as kimchi, sauerkraut, natto, kefir, etc.

 

[Dog-Slime]

If you wanna waste your time, peptides do not work orally none of them not one percent so stop wasting your money and time and stop following the wrong people. They only work subcutaneously so don't waste your money on BPC 157 unless you're taking it subcutaneously, they can actually cause more harm(orally)

BPC study
"The closest possible recommended dose is based on rat studies where ORAL administration showed benefit, as most studies administer the supplement via injection."

- oral surviving digestion in rats is well documented bro

KPV study
"Results

Nanomolar concentrations of KPV inhibit the activation of NF-κB and MAP kinase inflammatory signaling pathways, and reduce pro-inflammatory cytokine secretion. We found that KPV acts via hPepT1 expressed in immune and intestinal epithelial cells. Furthermore, ORAL administration of KPV reduces the incidence of DSS-, and TNBS-induced colitis indicated by a decrease in pro-inflammatory cytokine expression.
Conclusion

This study indicates that KPV is transported into cells by PepT1 and might be a new therapeutic agent for IBD."

- again a peptide worked ORALLY

"oh that's rats" - some bodybuilder trying to defend his lack of knowledge

" the upper digestive tract (mouth to ileum) is quite similar, making rats a useful, though imperfect, model for studying human nutrient absorption." - CAMBRIDGE university

imperfect yes it said that, quite similar yup it says that too! Which part is similar the upper digestive tract (where a peptide would get absorbed)

Spewing out some facts? Or confused about the topic?

 

[Pheedno]

I don’t believe in a lot of gut health supplements due to lack of evidence. There is a lot more marketing hype in that category.

When it comes to the gut, a high fiber diet is priority 1, 2, and 3. High fiber is better than anything for the microbiome that we are aware of (feeds good gut bacteria, produces beneficial short chain fatty acids, improves gut barrier, etc)

Then we want to look at fermented foods, such as kimchi, sauerkraut, natto, kefir, etc.

I'm on you're line of thinking. Done the gamut on supps and have clients that have run the the gamut(not from my suggestion). Not much moving the needle, or sporadic.
Agree with Tuttle on this, too.
Eating where you should. Easy, but tedious to find where the diet needs to fill the gaps. Especially for people(gen pop) who haven't ever had a consistent intake, anyway.
Fermented foods is the best entry, for sure. Higher fiber fruits and a husk or seed to add.

 

[AllOkJumpmaster]

@ScoobyPrep 's company NuEthix has some really nice gut formulations. I am a big fan of their Gut Defender and Biofilm Resolve. Used those for quite awhile. I also really trust Morphogen Nutrition (Nick Walker just became a co-owner there) and have for years. Their Biome and Enzymes are great. Cant go wrong with either of those two companies.

Hell yeah, Jason (Scooby) is the man, and all of NuEthix's products are awesome. One of the few guys on a short list in both the coaching industry and supplement industry I trust. There is not a single NuEthix product I would hesitate to recommend.

 

[bigjim6775]

BPC study
"The closest possible recommended dose is based on rat studies where ORAL administration showed benefit, as most studies administer the supplement via injection."

- oral surviving digestion in rats is well documented bro

KPV study
"Results

Nanomolar concentrations of KPV inhibit the activation of NF-κB and MAP kinase inflammatory signaling pathways, and reduce pro-inflammatory cytokine secretion. We found that KPV acts via hPepT1 expressed in immune and intestinal epithelial cells. Furthermore, ORAL administration of KPV reduces the incidence of DSS-, and TNBS-induced colitis indicated by a decrease in pro-inflammatory cytokine expression.
Conclusion

This study indicates that KPV is transported into cells by PepT1 and might be a new therapeutic agent for IBD."

- again a peptide worked ORALLY

"oh that's rats" - some bodybuilder trying to defend his lack of knowledge

" the upper digestive tract (mouth to ileum) is quite similar, making rats a useful, though imperfect, model for studying human nutrient absorption." - CAMBRIDGE university

imperfect yes it said that, quite similar yup it says that too! Which part is similar the upper digestive tract (where a peptide would get absorbed)

Spewing out some facts? Or confused about

It's funny how people just wanna argue the fact that they're right you wanna believe something that doesn't work work you go ahead dude it's a free world. You've probably taken many things that don't work. I'm done arguing. I'm right. I know it works. That way. Human biology does not change for anything. It is what it is even if there was a one percent chance it doesn't work orally. Why would you argue the fact and pay for and take it orally when you know 100% of the time it works subcutaneously OK have a good day you do you I fixed my auto immune disease because I'm a fucking idiot. OK take care.

 

[qbkilla]

you took the words right out my mouth. nothing works better. kimchi, saurkraut, kombuch, sourdough have completely optimized my gut health. I used to rely on probiotic supps but listening to Chris Tuttle he pointed out while they have a high count the gut flora they produce is not as diverse as what you would get from whole foods.

This. Netflix actually has a great documentary on gut health. Zero mention of pills and drugs, its all about avoiding processed garbage and getting a variety of veggies..I think they suggested 20 to 30 different fruits and veggies a day. I wouldn’t be surprised if there was a correlation between what we term "good bodybuilding genetics " and gut diversity. Perhaps why anyone can force feed and grow but why do some look tight /full x-frame while others get bloated and have digestive issues...could be all about how we assimilate and absorb nutrients

 

[Dog-Slime]

It's funny how people just wanna argue the fact that they're right you wanna believe something that doesn't work work you go ahead dude it's a free world. You've probably taken many things that don't work. I'm done arguing. I'm right. I know it works. That way. Human biology does not change for anything. It is what it is even if there was a one percent chance it doesn't work orally. Why would you argue the fact and pay for and take it orally when you know 100% of the time it works subcutaneously OK have a good day you do you I fixed my auto immune disease because I'm a fucking idiot. OK take care.

I'm not trying to start a back and forth argument with you bro but I provided two studies showing they worked orally in rats and the information from a highly accredited university that rats were a good model for studying absorption in humans...

"Dihexa is an ORALLY active, brain-penetrant oligopeptide that significantly promotes synaptic connectivity, reverses cognitive decline, and reduces neuroinflammation in preclinical Alzheimer’s models
. Studies confirm it can be administered via capsule or abdominal injection to improve motor function and memory"

The Procognitive and Synaptogenic Effects of Angiotensin IV–Derived Peptides Are Dependent on Activation of the Hepatocyte Growth Factor/c-Met System - PMC

A subset of angiotensin IV (AngIV)–related molecules are known to possess procognitive/antidementia properties and have been considered as templates for potential therapeutics. However, this potential has not been realized because of two factors: 1) ...

pmc.ncbi.nlm.nih.gov

from that link: "Previous studies from our laboratory have demonstrated that ORAL delivery of dihexa can normalize or improve spatial learning..."

 

[ChickenRiceRepeat]

Looking supplement company recommendations for gut health and repairing gut balance, I know glutamine is a must but curious what others have used that have actually helped again not looking for peptides or anything like that but just supplements to aid in repairing the gut. I have tried the revive gut health and it worked well, but ive also looked at like Cement factory gut and it looked really good.

Something that is done by Chris Tuttle, one of the coaches I hold in the highest regard, is prescribing one kambucha drink daily prior to bed for gut issues.

This will provide the necessary prebiotics or probiotics (I forget which) necessary to help your gut break down food in a way supplements can not replicate.

He also advises I believe it’s either 15g or 45g of sauerkraut 2-3x daily for the same purpose, Greek yogurt also helps as well.

Also, when it comes to fruit and veg, even if you can’t tolerate them without gut issues do NOT avoid them. Rather than avoid them, Tuttle advocates to consume them in very small amounts and increase this over time.

I like using frozen veg and fruit that contain a variety on one bag, the ones I’m buying now have 6-8 kinds in each for veg and 4-5 for fruit.

Even adding say 5-10g each of 3-4 kinds of veg a couple times a day is an acceptable starting point if that’s all you can handle, you will be able to increase over time.

Of course an elimination diet can help you understand the triggers, but this approach Tuttle considers more appropriate to rebuild gut health long term once an elimination diet has been used to determine which foods are safe in larger amounts.

 

[romo]

We all know injections have a better absorption rate than oral. I do both of bpc. Injections helped my joint pain and overall systematic inflammation. But not my ibs so much. Most oral bpc are enteric coated. Surviving the stomach acid and making its way into the small intestines. Lower percentage rate yes, but its there, and it does its job better for direct gut health. Common sense really. It helped my ibs tremendously, where not so much with injections.

 

[Heady Muscle 2]

MycoBotanicals® Microbiome* Powder

MycoBotanicals Microbiome* mushroom & herb promotes balanced intestinal and immune functioning with probiotics.* Pre & probiotics for digestive health.* Turkey Tail, Lion’s Mane, Reishi, Marshmallow Root, Burdock Root & Probiotic Blend.

hostdefense.com

Kombucha
Goat Yogurt
MRM Digest All

 

[specter]

This. Netflix actually has a great documentary on gut health. Zero mention of pills and drugs, its all about avoiding processed garbage and getting a variety of veggies..I think they suggested 20 to 30 different fruits and veggies a day. I wouldn’t be surprised if there was a correlation between what we term "good bodybuilding genetics " and gut diversity. Perhaps why anyone can force feed and grow but why do some look tight /full x-frame while others get bloated and have digestive issues...could be all about how we assimilate and absorb nutrients

How would that even work ?

 

[qbkilla]

How would that even work ?

Ooops...I meant to say week. Still not easy. Last week I had carrots, squash, spinach, avocado, strawberry, blueberries, blackberry, pineapple, cherry, appl, banana...still only 11. Seems unrealistic to me too.

https://www.netflix.com/tudum/articles/hack-your-health-secrets-of-your-gut-release-date-trailer-news

 

[buck]

I have seen studies showing taking probiotics especially when coming back from using antibiotics. Through the ratios off what the person themselves actually need as everyone doesn't; have the same amount/ratios. And recovered quicker when the just ate their healthy diet and let the body do it job.

 

[ChickenRiceRepeat]

I have seen studies showing taking probiotics especially when coming back from using antibiotics. Through the ratios off what the person themselves actually need as everyone doesn't; have the same amount/ratios. And recovered quicker when the just ate their healthy diet and let the body do it job.

Well yeah antibiotics absolutely nuke your gut micro biome situation.

This is one of the multiple reasons I avoid antibiotics despite being recommended by a physician unless absolutely necessary.

They tried to give me some for a dental procedure recently which I’m very glad I denied, it truly throws my digestion for a major loop and destroys my appetite.

I think the literature indicates that the side effects get worse and that antibiotics lose effectiveness over multiple separate uses, one of the two but don’t hold me to that part, it’s a vague memory of reading that when I researched them.

 

[nothuman]

I don’t believe in a lot of gut health supplements due to lack of evidence. There is a lot more marketing hype in that category.

When it comes to the gut, a high fiber diet is priority 1, 2, and 3. High fiber is better than anything for the microbiome that we are aware of (feeds good gut bacteria, produces beneficial short chain fatty acids, improves gut barrier, etc)

Then we want to look at fermented foods, such as kimchi, sauerkraut, natto, kefir, etc.

Just to be clear, the best foods for the gut are high fiber foods like legumes, oats, certain fruits, certain veggies, etc.

Eat your beans before ordering your supplements that may or may not help

 

[JUICEDUP3]

If you wanna waste your time, peptides do not work orally none of them not one percent so stop wasting your money and time and stop following the wrong people. They only work subcutaneously so don't waste your money on BPC 157 unless you're taking it subcutaneously, they can actually cause more harm(orally)

understand.. I would only do subq personally. My girl been having gut issues so didnt know if oral would benefit her

 

[specter]

Ooops...I meant to say week. Still not easy. Last week I had carrots, squash, spinach, avocado, strawberry, blueberries, blackberry, pineapple, cherry, appl, banana...still only 11. Seems unrealistic to me too.

https://www.netflix.com/tudum/articles/hack-your-health-secrets-of-your-gut-release-date-trailer-news

Ah ok, yeah 20-30 a week i can see, but every dang day

 

[ChickenRiceRepeat]

understand.. I would only do subq personally. My girl been having gut issues so didnt know if oral would benefit her

Oral bpc absolutely has a large effect on the gut, and Heres why:

The digestive tract is technically outside of your body. It’s not “in the system”. Think of your body like a hollow tube, something has to be absorbed through the side of the tube (gut, intestines) or injected into the tube (skin on outside of body) to be absorbed into the system.

Having bpc pass through the gut provides unique benefits that are not present in injection administration.

Sure the bioavailability is lower, but it has a totally different effect on gut health.

Sorry if the analogy was butchered I stole it from someone much smarter than myself, but the idea is that just because something goes into your mouth doesn’t mean it’s inside of the system of your body, this is why we can eat certain types of fibre and have said fibre never enter our system, because it never gets inside of the system of the body, it just passes through the hollow tube of our body.

 

[Sterops]

Nothing beats a diet

 

[BigKevKris]

Also IdAnimal (Doug RIP) Had tons research on high dose melatonin for stomach issues upwards of 50mgs .

50mgs? Holy shit, I am definitely looking into this one.....got to be some side effects at that dose.