HCG Sub-Q or mix?

[kcbuilder]

Can you mix HCG with your oils or is it sub-Q only?

 

[Boo]

I don't know if it can mixed, but it can be taken IM as well.

Boo

 

[617ricky]

It can be taken IM, but I personally wouldn't want it absorbing mixed with gear.. And an SQ injection releases it better I read.. It shouldn't be a big deal when you can do it SQ with a 30g which you don't even feel at all and doesn't leave a mark..

 

[MR. BMJ]

Save yourself some scar tissue and inject it subQ....just like HGH.

Works like a charm

BMJ

 

[kcbuilder]

I heard you could go IM, I just figured if your going IM with your gear. Why not just pull your HCG and run it all in one poke. not to mention saving a few bucks on thin pins.

I was mostly curious about mixing of oil with water for an IM injection.


thx for the info though.

 

[HOTROCKS]

A randomized three-way cross-over study in healthy pituitary-suppressed women to compare the bioavailability of human chorionic gonadotrophin (Pregnyl) after intramuscular and subcutaneous administration

BM Mannaerts, TB Geurts and J Odink
Clinical Development Department, NV Organon, Oss, The Netherlands.

The objective of this study was to compare the bioavailability of s.c. and i.m. administration of human chorionic gonadotrophin (HCG; Pregnyl). In a randomized, single-centre, three-way cross-over study, 18 healthy pituitary-suppressed volunteers were assigned to single HCG injections of 5000 and 10,000 IU i.m. and 10,000 IU s.c. Rate (Cmax, t(max)) and extent [area under curve from zero to infinity (AUC(0- infinity))] of absorption of HCG were determined. Serum immunoactive HCG increased from 0.4-0.5 IU/l at baseline to mean peak concentrations, which were reached 20 h after injection of 156 IU/l with 5000 IU i.m., of 307 IU/l with 10,000 IU i.m. and of 339 IU/l with 10,000 IU s.c. Eight days after administration, < 10% of the maximum HCG activity was found for each regimen. The elimination half-life (t(1/2)) was on average 32-33 h, irrespective of the treatment regimen. Intramuscular and s.c. injections of 10,000 IU HCG were bioequivalent with respect to AUC(0-infinity). The Cmax and t(max) were also similar between the two administration routes but bioequivalence could not be proven due to intersubject variability. Intramuscular doses of 5000 IU and 10,000 IU HCG were dose-proportional. Since s.c. HCG is bioequivalent to i.m. HCG with respect to extent of absorption (its major pharmacokinetic variable) and is well tolerated, the s.c. administration route may be effectively and safely used in assisted reproduction. Moreover, since s.c. injection can be performed by the patients themselves, acceptability may be enhanced.