Healing protocols for this injury

[Scorch]

I had a tibial plateau fracture a couple years ago and ended up with 7 screws and a plate in my leg. I recently went to check up with the surgeon who did my final surgery and he recommended running a short test/HGH cycle. There was no further direction after the statement. I am making progress, but still have muscle atrophy in my left leg. Someone else said test/anavar/hgh. Any recommendations on test dosage, length of cycle, GH vs. MK-677 or Sermorelin? I've seen PCT including Clomid, Novadex, Armidex, HCG, etc. Any recommendations would be great as this is very new for me.

Spend a little more time on the left leg than your right. As far as the gear, I'd do 200 test prop. No sense in going crazy and just build from there if that's the route you want to go.

Late reply, but getting inflammation and pain under control doesn't mean any underlying injury is healing. Just like the case of the friend in the original post. He plays rugby, it hurts him, then it eventually feels better. He posted that it's a torn tendon, a ruptured ligament, and bursitis. I'm sure BPC157 would help the inflammation/control pain, including the bursitis, but it's not going to heal a torn tendon and ruptured ligament.

Right on. Now he's got more information and more research to do to make the best choice for him/friend.

 

[thethinker48]

Late reply, but getting inflammation and pain under control doesn't mean any underlying injury is healing. Just like the case of the friend in the original post. He plays rugby, it hurts him, then it eventually feels better. He posted that it's a torn tendon, a ruptured ligament, and bursitis. I'm sure BPC157 would help the inflammation/control pain, including the bursitis, but it's not going to heal a torn tendon and ruptured ligament.

100% True

I have no ACL and half a meniscus in my left knee, I popped it again last week grappling, and I think it's the 11th or 12th time in 2 years. Taking BPC reduces the inflammation and swelling and makes the return to activity normal but won't compensate for a torn ligament

 

[Scorch]

I'll do my best to post up some articles on here since there seems to be a lot of confusion and I want to make sure everyone reads up.

There's a big misconception with inflammation being the sole benefit of BPC. Mainly due to it being the easiest to find. Sikiric et al., 1993–2020 by a Croatian research team. The new trials show evidence of BPC increasing VEGF( Vascular Endothelial Growth Factor) which plays a key role in angiogenesis new blood vessel formation and tissue repair and there is current ongoing research that supports osteogenesis from VEGF, specifically VEGF-A. There is also a study that show BPC-157 enhancing VEGF mRNA and protein levels, likely through signaling cascades that promote endothelial cell proliferation and migration.

I highly encourage you guys to do your research when it comes to this stuff and look for confluence. Don't take my word for it or anyone elses. There's plenty of members here that report healing benefits that aren't looking to heal "inflammation". Which btw, would be KPV.

Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing - PubMed

Angiogenesis is a natural and complex process controlled by angiogenic and angiostatic molecules, with a central role in healing process. One of the most important modulating factors in angiogenesis is the vascular endothelial growth factor (VEGF). Pentadecapeptide BPC 157 promotes healing...

pubmed.ncbi.nlm.nih.gov

Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation - PubMed

BPC 157 promotes angiogenesis in CAM assay and tube formation assay. BPC 157 accelerates the blood flow recovery and vessel number in rats with hind limb ischemia. BPC 157 up-regulates VEGFR2 expression in rats with hind limb ischemia and endothelial cell culture. BPC 157 promotes VEGFR2...

pubmed.ncbi.nlm.nih.gov

Achilles detachment in rat and stable gastric pentadecapeptide BPC 157: Promoted tendon-to-bone healing and opposed corticosteroid aggravation - PubMed

Stable gastric pentadecapeptide BPC 157 (BPC 157, as an antiulcer agent in clinical trials for inflammatory bowel disease; PLD-116, PL 14736, Pliva, no toxicity reported) alone (without carrier) ameliorates healing of tendon and bone, respectively, as well as other tissues. Thereby, we focus on...

pubmed.ncbi.nlm.nih.gov

 

[KingOfSushi]

I'll do my best to post up some articles on here since there seems to be a lot of confusion and I want to make sure everyone reads up.

There's a big misconception with inflammation being the sole benefit of BPC. Mainly due to it being the easiest to find. Sikiric et al., 1993–2020 by a Croatian research team. The new trials show evidence of BPC increasing VEGF( Vascular Endothelial Growth Factor) which plays a key role in angiogenesis new blood vessel formation and tissue repair and there is current ongoing research that supports osteogenesis from VEGF, specifically VEGF-A. There is also a study that show BPC-157 enhancing VEGF mRNA and protein levels, likely through signaling cascades that promote endothelial cell proliferation and migration.

I highly encourage you guys to do your research when it comes to this stuff and look for confluence. Don't take my word for it or anyone elses. There's plenty of members here that report healing benefits that aren't looking to heal "inflammation". Which btw, would be KPV.

Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing - PubMed

Angiogenesis is a natural and complex process controlled by angiogenic and angiostatic molecules, with a central role in healing process. One of the most important modulating factors in angiogenesis is the vascular endothelial growth factor (VEGF). Pentadecapeptide BPC 157 promotes healing...

pubmed.ncbi.nlm.nih.gov

Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation - PubMed

BPC 157 promotes angiogenesis in CAM assay and tube formation assay. BPC 157 accelerates the blood flow recovery and vessel number in rats with hind limb ischemia. BPC 157 up-regulates VEGFR2 expression in rats with hind limb ischemia and endothelial cell culture. BPC 157 promotes VEGFR2...

pubmed.ncbi.nlm.nih.gov

Achilles detachment in rat and stable gastric pentadecapeptide BPC 157: Promoted tendon-to-bone healing and opposed corticosteroid aggravation - PubMed

Stable gastric pentadecapeptide BPC 157 (BPC 157, as an antiulcer agent in clinical trials for inflammatory bowel disease; PLD-116, PL 14736, Pliva, no toxicity reported) alone (without carrier) ameliorates healing of tendon and bone, respectively, as well as other tissues. Thereby, we focus on...

pubmed.ncbi.nlm.nih.gov

I always viewed the main benefit of BPC being the angiogenesis aspect, and viewed TB as more for inflammation.

 

[alfresco]

First, stop doing / avoid doing what is causing the pain.

Get the best “shoulder doc” you can afford.

My left shoulder is fucked structurally (80% bone on bone.) but what has been a savior is hyaluronic acid, cortisone, and PRP injection (all at the same time . . the needle stays in). First visit, took a few weeks to have a positive effect. Subsequent visits, positive effects were almost immediately felt, like the next day is not sooner. And I remain pain free until the next visit. I do this once a quarter, in fact getting it done week. Hoping the PRP will stimulate some some cartilage re-growth. And hoping to stave off a shoulder replacement . . . but not bad enough . . . yet . . . fingers crossed.

Hope this helps.

Disclaimer: Your mileage may vary.

Today I just had another Cortizone and a hyaluronic injection in my shoulder. This combo has provided tremendous relief and the PRP injection I had a while ago seems to be working as a side-by-side comparison of my shoulder via x-rays,shows that I may have some cartilage regeneration, but clearly it is not getting worse, so we’re on the right path.

 

[Scorch]

Today I just had another Cortizone and a hyaluronic injection in my shoulder. This combo has provided tremendous relief and the PRP injection I had a while ago seems to be working as a side-by-side comparison of my shoulder via x-rays,shows that I may have some cartilage regeneration, but clearly it is not getting worse, so we’re on the right path.

Happy to read its working for ya man. There's a peptide that's been making the rounds recently when it comes to cartilage which I intend to read up on whenever I get the opportunity but I'll post the med research for you.

Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes - PMC

Autologous chondrocyte implantation (ACI) is a procedure used to treat articular cartilage injuries and prevent the onset of post-traumatic osteoarthritis. In vitro expansion of chondrocytes, a necessary step in ACI, results in the generation of ...

pmc.ncbi.nlm.nih.gov

Specifically the paragraph following figure 3.

Hopefully when I get the opportunity I can test my rat with the cocktail shot of FoxO4/GH/BPC and repair some of his cartilage in his shoulder.

 

[alfresco]

Happy to read its working for ya man. There's a peptide that's been making the rounds recently when it comes to cartilage which I intend to read up on whenever I get the opportunity but I'll post the med research for you.

Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes - PMC

Autologous chondrocyte implantation (ACI) is a procedure used to treat articular cartilage injuries and prevent the onset of post-traumatic osteoarthritis. In vitro expansion of chondrocytes, a necessary step in ACI, results in the generation of ...

pmc.ncbi.nlm.nih.gov

Specifically the paragraph following figure 3.

Hopefully when I get the opportunity I can test my rat with the cocktail shot of FoxO4/GH/BPC and repair some of his cartilage in his shoulder.

Haven’t looked at the links yet, but if you have a link to the research that you mentioned, that would be great. I’ll pass it on to my doctor.

 

[fisther69]

Today I just had another Cortizone and a hyaluronic injection in my shoulder. This combo has provided tremendous relief and the PRP injection I had a while ago seems to be working as a side-by-side comparison of my shoulder via x-rays,shows that I may have some cartilage regeneration, but clearly it is not getting worse, so we’re on the right path.

I have had many prp injections…never felt they worked

 

[PoptartPsycho]

First, stop doing / avoid doing what is causing the pain.

Get the best “shoulder doc” you can afford.

My left shoulder is fucked structurally (80% bone on bone.) but what has been a savior is hyaluronic acid, cortisone, and PRP injection (all at the same time . . the needle stays in). First visit, took a few weeks to have a positive effect. Subsequent visits, positive effects were almost immediately felt, like the next day is not sooner. And I remain pain free until the next visit. I do this once a quarter, in fact getting it done week. Hoping the PRP will stimulate some some cartilage re-growth. And hoping to stave off a shoulder replacement . . . but not bad enough . . . yet . . . fingers crossed.

Hope this helps.

Disclaimer: Your mileage may vary.

Hi, can you give an update on how things are going with you now? How long have you been following this protocol all together? So basically, they just prefill the syringe and swap them out while the needle is in you for the three injections? Thank you.

 

[alfresco]

I believe you have the needle protocol correct. The doctor and I believe the ERP protocol is at worst maintaining at best improving and we will continue to do that on an annual basis. Here are the results of my last MRI.

COMPARISON: MRI SHOULDER LEFT WO CONTRAST 2025-May-01 INDICATIONS: DJD, interval study post PRP Left shoulder pain TECHNIQUE: Utilizing a state of the art MRI scanner, a variety of imaging sequences were performed. FINDINGS: ROTATOR CUFF: Persistent but decreased signal abnormality in the infraspinatus insertion measuring 7 mm. No new rotator cuff abnormality. MUSCLES: Minimal T2 hyperintensity in the distal infraspinatus muscle. LIGAMENTS: Normal. LABRUM: No discrete tear. A/C JOINT: Mild osteoarthritis. ACROMION: Type II. BICEPS: Intact. BONES: Mild to moderate glenohumeral osteoarthritis, unchanged. OTHER: None. CONCLUSION: Stable mild to moderate glenohumeral osteoarthritis. Persistent but decreased signal abnormality at the infraspinatus insertion. No new rotator cuff tear. New mild edema in the infraspinatus muscle which may reflect a low-grade muscular strain.