I did, I constantly had low E2... Which for me was strange because I normally produce a lot of estrogen. I required up to 1mg adex EOD for 750mg of test for levels to be "normal" range. So when I was taking anti es it was just annihilating my E2 (wasnt doing bloods), eventually did than saw it. Stood off anti es for a long time and still was not normal. Body just did not respond to really any gear at all at that time period. It wasnt until I did treatment, got done with that etc, that I started responding normally again to gear and even than just did not feel right.