HGH/ Ipamorelin together?

[Powerhouse88]

Stick to hgh alone or peptides alone. Rather spend the extra money on more growth. But that’s just me

 

[Type-IIx]

He listed a bunch of them in the screenshot I posted and said GH use could be improved upon if there was access to those other isoforms. "a 2iu bolus of 22-kd could be as potent as 20-30iu"

I mean, it's possible for compounds to activate the GHR with 1/10-1/15 (i.e., with considerably LESS signaling ability) as 22kDa, but that would seem to be the opposite from what he's implying (that there could be some 35kDa hGH "isoform" (LOL) that is more potent than 22K-GH). Without delving into the GHR conformational changes/signaling, 22K-GH cannot be "engineered" in the sense this huckster implies. It's not the first time I've heard Kikel called a fraud, this really demonstrates that.

The modern view of hGH and its isoform (20K-GH, comprising 5-10% of GH circulation in blood) is that 22kDa-GH is "evolutionarily optimized," in that primate GH can activate non-primate GHR but not vice versa. Human GH activates porcine GHR more strongly than porcine. Yao-xia, L., Jin g-yan, C., Xia-lian, T., Ping, C., & Min, Z. (2017). The 20 kDa and 22 kDa forms of human growth hormone (hGH) exhibit different intracellular signalling profiles and properties. General and Comparative Endocrinology, 248, 49–54. doi:10.1016/j.ygcen.2017.04.010

 

[KillerStack]

I mean, it's possible for compounds to activate the GHR with 1/10-1/15 (i.e., with considerably LESS signaling ability) as 22kDa, but that would seem to be the opposite from what he's implying (that there could be some 35kDa hGH "isoform" (LOL) that is more potent than 22K-GH). Without delving into the GHR conformational changes/signaling, 22K-GH cannot be "engineered" in the sense this huckster implies. It's not the first time I've heard Kikel called a fraud, this really demonstrates that.

The modern view of hGH and its isoform (20K-GH, comprising 5-10% of GH circulation in blood) is that 22kDa-GH is "evolutionarily optimized," in that primate GH can activate non-primate GHR but not vice versa. Human GH activates porcine GHR more strongly than porcine. Yao-xia, L., Jin g-yan, C., Xia-lian, T., Ping, C., & Min, Z. (2017). The 20 kDa and 22 kDa forms of human growth hormone (hGH) exhibit different intracellular signalling profiles and properties. General and Comparative Endocrinology, 248, 49–54. doi:10.1016/j.ygcen.2017.04.010

Thanks, I'm just too lazy to delve into all this myself lol.

 

[btails]

I mean, it's possible for compounds to activate the GHR with 1/10-1/15 (i.e., with considerably LESS signaling ability) as 22kDa, but that would seem to be the opposite from what he's implying (that there could be some 35kDa hGH "isoform" (LOL) that is more potent than 22K-GH). Without delving into the GHR conformational changes/signaling, 22K-GH cannot be "engineered" in the sense this huckster implies. It's not the first time I've heard Kikel called a fraud, this really demonstrates that.

The modern view of hGH and its isoform (20K-GH, comprising 5-10% of GH circulation in blood) is that 22kDa-GH is "evolutionarily optimized," in that primate GH can activate non-primate GHR but not vice versa. Human GH activates porcine GHR more strongly than porcine. Yao-xia, L., Jin g-yan, C., Xia-lian, T., Ping, C., & Min, Z. (2017). The 20 kDa and 22 kDa forms of human growth hormone (hGH) exhibit different intracellular signalling profiles and properties. General and Comparative Endocrinology, 248, 49–54. doi:10.1016/j.ygcen.2017.04.010

Whats your background if you dont mind me asking? A scientist of sorts?

Your posts are on a different level. Reminds me of when datbtrue used to answer my pm's lol.