Honest question, has the anabolic industry already peaked?

[Anabolix8]

Most compounds we use today are decades old. Aside from delivery methods and minor tweaks, are we actually seeing innovation or just repackaging the same drugs?

Is there really anything groundbreaking left?

 

[td]

The industry seems to be focused on peptides. We'll see which of these novel compounds have staying power

I remember reading about Vic Conte. How did a musician synthesize a new, undetectable steroid. I'm sure many are now aware, but he didn't. He found tetrahydrogestrinone in old Russian literature and Patrick Arnold synthesized it.

With the help of AI tools will someone be able to develop a new androgen structure? Or locate another compound in forgotten research that was never pursued further?

I expect pharmaceutical companies are researching ways to mitigate the potential muscle loss associated with GLP use.

I remain highly skeptical of any claims of successful myostatin inhibition. I can't intuit how such a compound wouldn't also affect cardiac muscle tissue.

 

[Stewie]

It would be fascinating to watch a brilliant biochemist engineer a highly selective kinase activator (or phosphatase inhibitor) that targets phosphorylation at the N-terminal domain serines of the androgen receptor-particularly Ser81 and/or Ser213.


Theoretically, boosting phosphorylation at these sites could amplify AR transcriptional activity and enhance skeletal muscle hypertrophy, especially via cross-talk with growth factor pathways like IGF-1/Akt for Ser213. In an ideal world, this approach would deliver muscle-specific gains with zero off-target effects.

I've thought about pitching this idea to a few chemists I know – including PA.

 

[bbxtreme]

I think the industry is no different than the supplement industry. “All that is old becomes new again.”

Most industry’s just cycle through things as people make them fads. Collagen, creatine, magnesium. None are new by any stretch, but they sure seem like it right now due to how they’re marketed.

The PED space is much in the same- high test, high mast, orals, no orals. It’s whatever the influential people talk about and make stick.

I think people will continue to play with myostatin through bioregulators, which I believe are the next trend as a whole- bioregulators.

 

[Stewie]

It would be fascinating to watch a brilliant biochemist engineer a highly selective kinase activator (or phosphatase inhibitor) that targets phosphorylation at the N-terminal domain serines of the androgen receptor-particularly Ser81 and/or Ser213.


Theoretically, boosting phosphorylation at these sites could amplify AR transcriptional activity and enhance skeletal muscle hypertrophy, especially via cross-talk with growth factor pathways like IGF-1/Akt for Ser213. In an ideal world, this approach would deliver muscle-specific gains with zero off-target effects.

I've thought about pitching this idea to a few chemists I know – including PA.

Lightly touched on serine residues in these two threads– not specifically designing a drug:

Dr Dean: The best steroid doses & compounds, GH, & living long

I've done the CAG repeat test offered by Marek and my result (27) lines up with my personal experience in terms of response to training and PEDs. From what I read you want to be below 20 to have a favorable androgen receptor sensitivity. Fascinating you had this pulled! I've yet to explore my...

www.professionalmuscle.com

Glycine for better sleep.

Magnesium biglycinate Even though the elemental magnesium is somewhere between 11-20% with glycinate, there is not enough glycine in these types of products ...though it's a great 'salt' to pair with magnesium and actually the superior one.

www.professionalmuscle.com

 

[Durro NoHurtNoBigShirt]

Most compounds we use today are decades old. Aside from delivery methods and minor tweaks, are we actually seeing innovation or just repackaging the same drugs?

Is there really anything groundbreaking left?

Something in the future possibly but right now there's not anything that has come out that surpasses steroids for muscle growth nothing. Peptides have their place each peptide has a specific function but not for muscle growth. Anabolic Steroids are the Best! The Basics Always Work! That goes for everything.

 

[Heath82]

Still waiting on myostatin inhibitors lol

 

[Sectør]

In some senses it’s probably peaked, but that’s not to say that down the road there can’t be some innovation. I’m just not sure it will occur on the anabolic front. There’s been so many pro hormones and variations of compounds over the years and most just fall flat in the water

Test + GH will probably always be the core foundation of AAS. That I don’t really ever see changing. Other compounds will get trendy, but test+ gh+ X will always remain

The peptide industry does have some interesting and useful ones, and I think we’ll see plenty more of these in development with how much market capitalization potential there is in this field. I do think peptides as a whole are a bit overblown and overmarketed/hyped, but I think certain ones like Reta and mots-c have a lot of promise, and I’m sure there will be plenty of other new ones down the road

The myostatin inhibitor route is interesting too. Seems like a unicorn therapy that a lot of companies have tried to chase (or are chasing) with little success. A lot of the big name companies are plowing R&D money into these, especially in combination with GLP therapies in some of the trials.
- Pfizer tried to develop Domagrozumab which failed in phase 2 from lack of benefits
-Eli Lily developed Landogrozumab which has proven to be inconsistent
-regeneron is developing Trevogrumab which seems to be ongoing
-some company called Wyeth pharmaceuticals developed Stamulumab which had limited efficiency
-a parent company named scholar rock has a drug called Apitegromab which has shown promise in improving motor function in spinal muscle atrophy (how relevant this would be to bodybuilding use? I have no idea)

There’s also receptor/pathway blockers developed or in development like:
- Bimagrumab — which has shown some promise in limited human trials. Who knows what the risks are though
-ACE-031 was developed then halted due to bleeding issues
- KER-065 (Keros Pharma) — which is in early phase trials ; not sure what the data suggests on that yet

Then there’s the myostatin binding protein type drugs like Follistatin or gasp-1 which from my understanding seem to be ineffective and/or have a risky side effect profile

So it does seem like myostatin still might be the next path, they just haven’t gotten quite there yet.

 

[dantes]

It would be nice if big pharma invested in the development of further AAS but that will never happen. I think some of the recent peptides have been promising but nothing groundbreaking in terms of hypertrophy

 

[Worldsfastestfatty]

The anabolic steroids "industry" (not quite the right term, I don't feel) peaked 50 years ago now. There has been no significant investment in AAS since the late 60s with only limited investment in fringe compounds for HRT or Contraception - however neither route was fruitful.

The future of "anabolics" investment will be to prevent muscle wasting and likely to be highly targeted - so unlikely to be useful as a PED.

Unless we begin to embrace PED I doubt we will see much novel development in next 25 years that benefits our community in the same way as AAS does.

 

[AllOkJumpmaster]

I think the industry is no different than the supplement industry. “All that is old becomes new again.”

Most industry’s just cycle through things as people make them fads. Collagen, creatine, magnesium. None are new by any stretch, but they sure seem like it right now due to how they’re marketed.

The PED space is much in the same- high test, high mast, orals, no orals. It’s whatever the influential people talk about and make stick.

I think people will continue to play with myostatin through bioregulators, which I believe are the next trend as a whole- bioregulators.

Yeah dude, I remember Turkesterone being all the rage something like 2 decades ago, then nothing, then in about '21/'22 it was back in full force for some reason. Still doing nothing, at least not doing enough to justify it's cost. I feel like Colostrum was a similar thing.

That said, I do think things like BPC/TB, possibly other peps, and obviously GLP-1's are here to stay, these are effective and relatively safe, and beneficial to many different demographics.

SARMs are another thing that I think will lose steam if they even still have steam right now.

 

[bbxtreme]

Yeah dude, I remember Turkesterone being all the rage something like 2 decades ago, then nothing, then in about '21/'22 it was back in full force for some reason. Still doing nothing, at least not doing enough to justify it's cost. I feel like Colostrum was a similar thing.

That said, I do think things like BPC/TB, possibly other peps, and obviously GLP-1's are here to stay, these are effective and relatively safe, and beneficial to many different demographics.

SARMs are another thing that I think will lose steam if they even still have steam right now.

Agreed on the peptides- BPC and TB500 have been great additions, but they are not new by any means. The rest of the world just thinks they are because influencers started white listing them. Same with GLP’s, influencers made it “ok” or the new norm for the masses to take them, and from UGL sources.

SARM’s are interesting. We are all talking about mystatin, but the new bioregulators are being created for muscle preservation, not hypertrophy. We already have things like YK11 that are much stronger for myostatin IMO.

Check your DM’s when you get a moment.

 

[professionaldyel]

This is going to come off as I'm a tinfoil hat wearer when I'm not but it doesn't make any sense for government to let their general population get jacked as fuck with drugs. I don't think in our lifetime, that we're going to see anything new that is proven to increase contractile tissue at a rapid rate without killing you within 5 years of use.

 

[hawkmoon]

I think it peaked some time ago.

IMHO nothing will replace the practicality Test, Deca, Anadrol, Tren, GH and some insulin. The space to exploit will be healthier compounds.
With the proper training and nutrition and these PEDs most people will grow more tissue than they could ever need.
Those with the right genetic gifts will win many shows.

Many of the people I have come across haven't come close to optimizing their training or food anyway.
PEDs will always hold fascination, but not the necessarily the answers we are looking for (jedi mind-trick wave...)

 

[specter]

The industry seems to be focused on peptides. We'll see which of these novel compounds have staying power

I remember reading about Vic Conte. How did a musician synthesize a new, undetectable steroid. I'm sure many are now aware, but he didn't. He found tetrahydrogestrinone in old Russian literature and Patrick Arnold synthesized it.

With the help of AI tools will someone be able to develop a new androgen structure? Or locate another compound in forgotten research that was never pursued further?

I expect pharmaceutical companies are researching ways to mitigate the potential muscle loss associated with GLP use.

I remain highly skeptical of any claims of successful myostatin inhibition. I can't intuit how such a compound wouldn't also affect cardiac muscle tissue.

Yeah Patrick found an old book with about 4-500 diff steroids that never made it into the "world of medicine" and so they didnt have profiles of it, structure etc so he found the a couple and tried em out on athletes.

 

[specter]

It would be fascinating to watch a brilliant biochemist engineer a highly selective kinase activator (or phosphatase inhibitor) that targets phosphorylation at the N-terminal domain serines of the androgen receptor-particularly Ser81 and/or Ser213.


Theoretically, boosting phosphorylation at these sites could amplify AR transcriptional activity and enhance skeletal muscle hypertrophy, especially via cross-talk with growth factor pathways like IGF-1/Akt for Ser213. In an ideal world, this approach would deliver muscle-specific gains with zero off-target effects.

I've thought about pitching this idea to a few chemists I know – including PA.

 

[specter]

This is going to come off as I'm a tinfoil hat wearer when I'm not but it doesn't make any sense for government to let their general population get jacked as fuck with drugs. I don't think in our lifetime, that we're going to see anything new that is proven to increase contractile tissue at a rapid rate without killing you within 5 years of use.

Dude have you seen drone warfare ? no goverment gives a fuck about you being big..

 

[Orly23]

The new fade is peptides that’s what every one is focused on

 

[qbkilla]

This is going to come off as I'm a tinfoil hat wearer when I'm not but it doesn't make any sense for government to let their general population get jacked as fuck with drugs. I don't think in our lifetime, that we're going to see anything new that is proven to increase contractile tissue at a rapid rate without killing you within 5 years of use.

This! I hope it has peaked. I don’t need more or new drugs. We have new drugs, do guys look better or worse than the 70s? Id say much worse. People don't need more mass..they need better health, better digestion, less bloat, less injuries...I digress. The tools to build muscle and burn fat are present for those who chose to commit.

Now give me drugs to fix arthritis, cancer, gut health, all these horrible diseases any of us could get. But weightlioss is where the $$ is not helping sick kids.

/rant lol

 

[kadafi2]

We already have things like YK11 that are much stronger for myostatin IMO.

Have you tried YK11? There are few reviews about this product, and they're very mixed from what I remember.