Humanofort FGF-21

emeric delczeg · Oct 25, 2022

Fitch92 said:
Wow! I’ve been taking two per day for several years now. It’s just so expensive I have trouble justifying taking six per day.

You don`t need 6 , 2 minimum OK. If you look into the benefits is not expensive.

emeric delczeg · Oct 25, 2022

Fitch92 said:
Taking 6/day would be more expensive than script trt or UGL GH at 2iu/day. I’m not sure what the cost of manufacturing humanofort is but that’s nonsense.

It has way more benefits than HGH.

buck · Oct 25, 2022

Fitch92 said:
Wow! I’ve been taking two per day for several years now. It’s just so expensive I have trouble justifying taking six per day.

Virtuous said:
Yeah a bit pricey but I take 4/day as well.

And what benifits did you guys see that you can tell for sure were from this product?

01dragonslayer · Oct 25, 2022

emeric delczeg said:
How Humanofort Works:

Humanofort oligopetides extract containing naturally occurring growth factors (not to be confused with growth hormones). This oligopeptides pass intact through the gut into the blood stream, mainly by pinocytosis. This peptides are characterized as an adaptogenic on (i.e a product that helps to modify the equilibrium of hormones secreted by the adrenal cortex). This adoptogenic activity is a consequence of fine-tuning exerted by the growth factors from the standardized oligopeptides extract on the adrenal cortex. Due its mechanism of action (regulation by the growth factors in a paracrine manner of adrenal cortex activity) the growth factors from the oligopeptides helps to modify the equilibrium of all the hormones secreted by the adrenal glands.

Also these peptides supports to stimulate the division of mature cells and significantly supports to decrease the mortality of older cells, and assist the body in normalizing numerous cellular processes by activating the fibroblast growth factor receptors. When this occurs, healing is accelerated and a variety of cellular processes are normalized/ stabilized.

Humanofort helps bring balance to the hypothalamus-pituitary-adrenal axis. This assists the entire endocrine system in achieving homeostasis and efficient operation. Next, the endocrine system secretes hormones at optimum levels resulting in improved cellular signaling. Improved cellular signaling results in cellular rejuvenation and ultimately translates to optimal health longevity and restoration of youthful vitality to the body.

I'm a little naive when it comes to this stuff. I have done a little research but what does all this mean in layman's terms?

Fitch92 · Oct 25, 2022

buck said:
And what benifits did you guys see that you can tell for sure were from this product?

A significant improvement in overall since of well-being/better mood. Honestly that’s it but it’s noticeable enough for me to continue taking this supplement for years.

emeric delczeg · Oct 26, 2022

01dragonslayer said:
I'm a little naive when it comes to this stuff. I have done a little research but what does all this mean in layman's terms?

The repair and replacement of a cell is under the direction of these peptides (growth factors), not the hormones.

Virtuous · Oct 28, 2022

buck said:
And what benifits did you guys see that you can tell for sure were from this product?

Overall wellness, recovery, sense of well being. It won’t do loads for your physique the same way popping orals will, but it’ll enhance your overall health and extended our health can lead to opportunities to train better and longer.

emeric delczeg · Oct 31, 2022

Virtuous said:
Overall wellness, recovery, sense of well being. It won’t do loads for your physique the same way popping orals will, but it’ll enhance your overall health and extended our health can lead to opportunities to train better and longer.

It supports the kidney to produce more natural EPO, also supports androgen receptors activity, that why the combination with low dozes (10mg to 6mg) test per day it works so well.

emeric delczeg · Nov 4, 2022

Virtuous said:
Overall wellness, recovery, sense of well being. It won’t do loads for your physique the same way popping orals will, but it’ll enhance your overall health and extended our health can lead to opportunities to train better and longer.

Fibroblast growth factor type 2 signaling is critical for DNA repair in human keratinocyte stem cells

Ghida Harfouche 1, Pierre Vaigot, Walid Rachidi, Odile Rigaud, Sandra Moratille, Mélanie Marie, Gilles Lemaitre, Nicolas O Fortunel, Michèle T Martin
Affiliations expand

PMID: 20681019
PMCID: PMC2996082
DOI: 10.1002/stem.485

Free PMC article

Abstract

Tissue stem cells must be endowed with superior maintenance and repair systems to ensure genomic stability over multiple generations, which would be less necessary in more differentiated cells. We previously reported that human keratinocyte stem cells were more resistant to ionizing radiation toxicity than their direct progeny, the keratinocyte progenitor cells. In the present study we addressed the mechanisms underlying this difference. Investigations of DNA repair showed that both single and double DNA strand breaks were repaired more rapidly and more efficiently in stem cells than in progenitors. As cell signaling is a key regulatory step in the management of DNA damage, a gene profiling study was performed. Data revealed that several genes of the fibroblast growth factor type 2 (FGF2) signaling pathway were induced by DNA damage in stem cells and not in progenitors. Furthermore, an increased content of the FGF2 protein was found in irradiated stem cells, both for the secreted and the cellular forms of the protein. To examine the role of endogenous FGF2 in DNA repair, stem cells were exposed to FGF2 pathway inhibitors. Blocking the FGF2 receptor (FGF receptor 1) or the kinase (Ras-mitogen-activated protein kinase 1) resulted in a inhibition of single and double DNA strand-break repair in the keratinocyte stem cells. Moreover, supplementing the progenitor cells with exogenous FGF2 activated their DNA repair. We propose that, apart from its well-known role as a strong mitogen and prosurvival factor, FGF2 helps to maintain genomic integrity in stem cells by activating stress-induced DNA repair.

pdc · May 14, 2023

emeric delczeg said:
How Humanofort Works:

Humanofort oligopetides extract containing naturally occurring growth factors (not to be confused with growth hormones). This oligopeptides pass intact through the gut into the blood stream, mainly by pinocytosis. This peptides are characterized as an adaptogenic on (i.e a product that helps to modify the equilibrium of hormones secreted by the adrenal cortex). This adoptogenic activity is a consequence of fine-tuning exerted by the growth factors from the standardized oligopeptides extract on the adrenal cortex. Due its mechanism of action (regulation by the growth factors in a paracrine manner of adrenal cortex activity) the growth factors from the oligopeptides helps to modify the equilibrium of all the hormones secreted by the adrenal glands.

Also these peptides supports to stimulate the division of mature cells and significantly supports to decrease the mortality of older cells, and assist the body in normalizing numerous cellular processes by activating the fibroblast growth factor receptors. When this occurs, healing is accelerated and a variety of cellular processes are normalized/ stabilized.

Humanofort helps bring balance to the hypothalamus-pituitary-adrenal axis. This assists the entire endocrine system in achieving homeostasis and efficient operation. Next, the endocrine system secretes hormones at optimum levels resulting in improved cellular signaling. Improved cellular signaling results in cellular rejuvenation and ultimately translates to optimal health longevity and restoration of youthful vitality to the body.

According to what you say, humanofort could enter the senolytic segment and synergise with Fisetin and Quercetin?

I also understand that it could fall into the category of health extenders, such as Spermidine, NMN and Resveratrol'?

emeric delczeg · May 15, 2023

pdc said:
According to what you say, humanofort could enter the senolytic segment and synergise with Fisetin and Quercetin?

I also understand that it could fall into the category of health extenders, such as Spermidine, NMN and Resveratrol'?

You can`t compare the Humanofort to any other products, no other product contains all 23 FGFs, NGF, CTGF, EGF.

Fibroblast growth factors (FGFs) that signal through FGF receptors (FGFRs) regulate a broad spectrum of biological functions, including cellular proliferation, survival, migration, and differentiation. Several studies have recently implicated the in vitro biological functions of FGFs for tissue regeneration. However, to obtain optimal outcomes in vivo, it is important to enhance the half-life of FGFs and their biological stability. So that explains why is the best way to take the Humanofort minimum 2 x day, it helps and support the half- life.
6.3. Muscles
Muscle regeneration has also been greatly controlled by the FGFs which are abundant in regenerating areas of muscles [144, 145]. FGF6 is of particular interest because it is muscle specific and highly upregulated during muscle regeneration. FGF2 was demonstrated to promote the recruitment of skeletal muscle satellite cells using a single myofiber culture model [146]. Doukas et al. used a gene delivery system that encodes FGF2 and FGF6 for the repair of skeletal muscle [147]. Specifically, plasmid and adenovirus vectors were immobilized in a collagen-gelatin mixture that was then delivered to muscle wounds. They found early muscle angiogenic response and subsequent arteriogenesis, and muscle repair was also greatly enhanced showing regenerating myotubes with specific markers expressions. Although there have been some controversies regarding the critical role of FGFs in muscle repair [148], it is largely accepted that their roles in muscle regeneration are closely related to the revascularization process [149].
6.7. Bones
Possible effects of FGF2 on osteogenesis and bone regeneration have also been reported. Lisignoli et al. cultured BMSCs derived from rats within a hyaluronate-based polymer scaffold with or without FGF2 [102]. They found that the presence of FGF2 strongly enhanced the expression of osteogenic markers and mineralization, demonstrating a possible role in bone regeneration. Tabata et al. studied the role of FGF2 in a rabbit skull defect model [103]. Gelatin hydrogel was also used to incorporate FGF2 (100 μg) to form a polyionic complex and function as an effective carrier. At 12 weeks, the implants showed dramatic improvement in defect closure, bone mineral density, and bone regeneration in groups treated with varying doses (2 to 200 μg) of FGF2-gelatin when compared to an untreated group.
6.9. Nerves
As one of the neurotrophic factors, FGFs have been shown to enhance the in vitro survival and neurite extension of various types of neurons as well as in vivo wound healing and neuronal functions.
FGF2 is known to exist at the blood-brain barrier in matrix-bound and soluble form, and it is produced by astrocytes and has autocrine effects on astrocytes proliferation and stellation [158]. When compared to the soluble form, FGF2 bound to matrices has improved half life [159], and its effects on astrocytes can be potentiated [160, 161]. Delgado-Rivera et al. covalently linked FGF2 onto a nanofiber polymer scaffold and observed significant autocrine expression of FGF2 and the modulation of astrocytes-neuron interactions, suggesting the utility of the system in nerve injury and disease [5].
7. Concluding Remarks
Fibroblast growth factors (FGFs) that signal through FGF receptors (FGFRs) regulate a wide range of biological functions, including cell proliferation, survival, migration, and differentiation. Among the signal pathways, RAS/MAP kinase is known to be predominant in the case of FGFs. While the biological functions of FGFs are largely implicated in many types of cells in vitro through this signaling pathway, the maintenance of stability and half-life in vivo should be considered. Biomaterial-based systems, including delivery carriers of FGFs and scaffolds of stem cells regulated by the FGFs functions, have recently been potentially developed and shown to have many good results in vivo. Future clinical applications of FGFs in the regeneration of tissues, including skin, muscle, tendon/ligament, bone, tooth, and nerve tissues will be realized when their biological functions are maximized by the appropriate use of biomaterials and stem cells.

pdc · May 15, 2023

emeric delczeg said:
You can`t compare the Humanofort to any other products, no other product contains all 23 FGFs, NGF, CTGF, EGF.

Fibroblast growth factors (FGFs) that signal through FGF receptors (FGFRs) regulate a broad spectrum of biological functions, including cellular proliferation, survival, migration, and differentiation. Several studies have recently implicated the in vitro biological functions of FGFs for tissue regeneration. However, to obtain optimal outcomes in vivo, it is important to enhance the half-life of FGFs and their biological stability. So that explains why is the best way to take the Humanofort minimum 2 x day, it helps and support the half- life.
6.3. Muscles
Muscle regeneration has also been greatly controlled by the FGFs which are abundant in regenerating areas of muscles [144, 145]. FGF6 is of particular interest because it is muscle specific and highly upregulated during muscle regeneration. FGF2 was demonstrated to promote the recruitment of skeletal muscle satellite cells using a single myofiber culture model [146]. Doukas et al. used a gene delivery system that encodes FGF2 and FGF6 for the repair of skeletal muscle [147]. Specifically, plasmid and adenovirus vectors were immobilized in a collagen-gelatin mixture that was then delivered to muscle wounds. They found early muscle angiogenic response and subsequent arteriogenesis, and muscle repair was also greatly enhanced showing regenerating myotubes with specific markers expressions. Although there have been some controversies regarding the critical role of FGFs in muscle repair [148], it is largely accepted that their roles in muscle regeneration are closely related to the revascularization process [149].
6.7. Bones
Possible effects of FGF2 on osteogenesis and bone regeneration have also been reported. Lisignoli et al. cultured BMSCs derived from rats within a hyaluronate-based polymer scaffold with or without FGF2 [102]. They found that the presence of FGF2 strongly enhanced the expression of osteogenic markers and mineralization, demonstrating a possible role in bone regeneration. Tabata et al. studied the role of FGF2 in a rabbit skull defect model [103]. Gelatin hydrogel was also used to incorporate FGF2 (100 μg) to form a polyionic complex and function as an effective carrier. At 12 weeks, the implants showed dramatic improvement in defect closure, bone mineral density, and bone regeneration in groups treated with varying doses (2 to 200 μg) of FGF2-gelatin when compared to an untreated group.
6.9. Nerves
As one of the neurotrophic factors, FGFs have been shown to enhance the in vitro survival and neurite extension of various types of neurons as well as in vivo wound healing and neuronal functions.
FGF2 is known to exist at the blood-brain barrier in matrix-bound and soluble form, and it is produced by astrocytes and has autocrine effects on astrocytes proliferation and stellation [158]. When compared to the soluble form, FGF2 bound to matrices has improved half life [159], and its effects on astrocytes can be potentiated [160, 161]. Delgado-Rivera et al. covalently linked FGF2 onto a nanofiber polymer scaffold and observed significant autocrine expression of FGF2 and the modulation of astrocytes-neuron interactions, suggesting the utility of the system in nerve injury and disease [5].
7. Concluding Remarks
Fibroblast growth factors (FGFs) that signal through FGF receptors (FGFRs) regulate a wide range of biological functions, including cell proliferation, survival, migration, and differentiation. Among the signal pathways, RAS/MAP kinase is known to be predominant in the case of FGFs. While the biological functions of FGFs are largely implicated in many types of cells in vitro through this signaling pathway, the maintenance of stability and half-life in vivo should be considered. Biomaterial-based systems, including delivery carriers of FGFs and scaffolds of stem cells regulated by the FGFs functions, have recently been potentially developed and shown to have many good results in vivo. Future clinical applications of FGFs in the regeneration of tissues, including skin, muscle, tendon/ligament, bone, tooth, and nerve tissues will be realized when their biological functions are maximized by the appropriate use of biomaterials and stem cells.

Thank you Emeric,

I am not comparing it, I would just like to know if it has senolytic effects and then synergise with these kind of new active ingredients that are localising other targets as in a previous post you said “significantly supports to decrease the mortality of older cells”

emeric delczeg · May 15, 2023

pdc said:
Thank you Emeric,

I am not comparing it, I would just like to know if it has senolytic effects and then synergise with these kind of new active ingredients that are localising other targets as in a previous post you said “significantly supports to decrease the mortality of older cells”

Yes, decrease the mortality of older cells.

Swifto · May 16, 2023

If Humanofort has so many benefits, why hasn't some billion dollar pharmaceutical company picked it up and pushed/promoted it to their customers, users, open market?

mexbeast · May 16, 2023

I truly respect Emeric for everything he has accomplished, but it's hard for me to believe that any peptide (larger pep) or growth factor would make it intact past the stomach acid, maybe neutralize the acid and 10 to 15 minutes later take it?

emeric delczeg · May 17, 2023

Swifto said:
If Humanofort has so many benefits, why hasn't some billion dollar pharmaceutical company picked it up and pushed/promoted it to their customers, users, open market?

Because is not a drug and is not registered as a drug, here Abstract from the USA Patent:

(s7) ABSTRACT 7 Claims, No Drawings
The invention refers to a composition standardized in heterologous embryo-peptides, used as a dietary supplement and to a process for its obtainment. The composition consists of heterologous embryonic extract, standardized in embryo-peptides.

emeric delczeg · May 17, 2023

mexbeast said:
I truly respect Emeric for everything he has accomplished, but it's hard for me to believe that any peptide (larger pep) or growth factor would make it intact past the stomach acid, maybe neutralize the acid and 10 to 15 minutes later take it?

The Humanofort has endocytosis promoting activity and contains trypsin inhibitors.

Endocytosis allows cells to transport particles and molecules across the plasma membrane.

Trypsin inhibitors are compounds that block the ability of trypsin to break down amino acids (peptides). When you take high-quality trypsin inhibitor supplements, you will get the amino acids from your digestive system that your body needs. That way is good idea to take Humanofort with your BCAA or EAA acid supplement.

Also this oligopeptide passes intact through the gut into the blood stream, mainly by pinocytosis.

Pinocytosis a mechanism by which cells ingest extracellular fluid and its contents; it involves the formation of invaginations by the cell membrane, which close and break off to form fluid-filled vacuoles in the cytoplasm.

The size of the growth factors are smaller than 20 Daltons.
In the stomach, pepsin begins the digestion of dietary proteins by hydrolyzing them to smaller polypeptides, the Humanofort in not dietary protein.
The acid environment alters the conformation of pepsinogen so that it can cleave itself to yield pepsin this happens when you consume dietary proteins not when you consume oligo peptides.