HUMANOFORT contains 48.82 mcg endogenous NGF (Nerve Growth Factor) naturally, for each capsule administered.
Nerve Growth Factor (NGF) is a protein that plays a crucial role in the development, maintenance, and survival of nerve cells or neurons, in both the peripheral nervous system and the central nervous system. It is a member of the family of growth factors called neurotrophins.
Earlier reports suggest endogenous NGF is essential for hippocampus plasticity/memory, and NGF deprivation induces hippocampal-related memory and synaptic plasticity.
The study presented below shows that NGF administration facilitates long-term memory dependent on hippocamp and synaptic plasticity by increasing PARP-1 activity, a polymer that mediates PolyADP rebosillation and is important for memory formation.
The data presented provide the first evidence that endogenous NGF facilitates synaptic plasticity and memory capacity through polyADP-ribosylation of the PARP-1 mediated protein and activation of the PKA-CREB pathway.
NGF exercises its effects by attaching specific receptors called TrkA receptors (tyrosine kinase A receptors) to the surface of the target cells. This binding activates signaling pathways that lead to various cellular responses, including cellular growth, differentiation, and survival.
NGF deregulation has been involved in various neurological disorders, including Alzheimer's disease, where abnormal levels of NGF can contribute to the degeneration of cholinergic neurons. Researchers explore the the therapeutic potential of NGF and related compounds in the treatment of neurodegenerative diseases and nerve damage.
STUDIO CLINIC:
https://pubmed.ncbi.nlm.nih.gov/22771769/
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