Humanofort

[SOUR DIESEL]

Humanofort naturally occurring all 23 FGFs, so far 23 were discovered it will be more discovered in the future. Also contains CTGF (connective tissue growth factors), EGF (epidermal growth factors) NGF (nerve growth factors), Thymosin B -4 , miRNAs , 2 -AG and AEA.

^^^thank you

Just watch out for that pesky hepatocarcinoma:

"Fibroblast growth factor 19 (FGF19) is a protein that can promote liver carcinogenesis and is associated with hepatocellular carcinoma (HCC)"

^^^hey brother ..WOW ..oddly enough ..this was/is actually my concern as well ..& why i asked the question
(..i mean the LIVER is already an "organ-of-concern" in this lifestyle)

^^^& well ..it appears to be much more just "pesky hepatacarcinoma"



Fibroblast growth factor 19 (FGF19) is a gene that plays a complex role in cancer development, with different roles in different types of cancer:

• Hepatocellular carcinoma (HCC): FGF19 overexpression is associated with poor outcomes in HCC patients. FGF19 amplification is detected in 20% of HCC samples, and is associated with poor survival and tumor recurrence. FGF19 and FGFR4 are coexpressed in HCC and promote tumorigenesis.
  
  
• Prostate cancer: FGF19 stimulation increases cancer cell proliferation and invasion.
  
  
• Colorectal cancer (CRC): FGF19 and FGFR4 are coexpressed in CRC and facilitate tumor growth. FGF19-FGFR4 upregulates ELF4 expression, which promotes CRC metastasis.
  
  
• Esophageal cancer, intestinal cancer, and skin cancer: Missense and silent mutations in FGF19 are observed in these cancers.

FGF19 is a member of the FGF family, which is involved in cancer progression, angiogenesis, embryogenesis, and tissue homeostasis. The FGF19 subfamily is called hormone-like FGFs, and includes FGF19, FGF21, and FGF23

&

" Fibroblast growth factor (FGF) receptor 4 (FGFR4) belongs to a family of tyrosine kinase receptor. FGFR4 is highly activated in certain types of cancer and its activation is closely associated with its specific ligand, FGF19. Indeed, FGF19-FGFR4 signaling is implicated in many cellular processes including cell proliferation, migration, metabolism, and differentiation. Since active FGF19-FGFR4 signaling acts as an oncogenic (←substances/factors that can cause/perpetuate cancer) pathway in certain types of cancer, the development and therapeutic evaluation of FGFR4-specific inhibitors in cancer patients is a topic of significant interest. "
" The FGF19 genomic locus is on the chromosome 11q13.3, and is frequently amplified in human cancers. For example, amplification of the FGF19 genomic locus including the well-established proto-oncogene CCND1, was found in liver cancer, breast cancer, lung cancer, bladder cancer and esophageal cancer (Sawey et al., 2011; Hoover et al., 2015; Tiong et al., 2016; Zhang et al., 2017). Hyperactivation of FGFR4 by FGF19 was reported in colon cancer cells and hepatocellar carcinoma. An animal model showed that a neutralizing antibody against FGF19 was able to abrogate liver cancer development in transgenic mice and inhibited xenograft tumors from HCC and colon cancer, suggesting feasibility of FGF19 as a therapeutic target (Desnoyers et al., 2008; French et al., 2012). "
" Accumulating evidence indicates that FGFR4 plays a critical role in cancer progression and metastasis, particularly in those cancer patients who have FGF19 amplification. "

↑seems that FGF19 & FGF4 are BFF ..FGF19 ramps-up/increases FGF4 ..& FGF4 does the stabbing
↑these are just "some" of the highlights ..there's a shit-ton more if anyone wants to read

►LINK:

Dissecting the Role of the FGF19-FGFR4 Signaling Pathway in Cancer Development and Progression - PMC

Fibroblast growth factor (FGF) receptor 4 (FGFR4) belongs to a family of tyrosine kinase receptor. FGFR4 is highly activated in certain types of cancer and its activation is closely associated with its specific ligand, FGF19. Indeed, FGF19-FGFR4 ...

pmc.ncbi.nlm.nih.gov

&

" Hepatocellular carcinoma (HCC) is the fifth most common type of cancer and the third leading cause of cancer-related deaths worldwide.
Fibroblast growth factor (FGF) 19 was amplified in patients with HCC (HepatoCellular Carcinoma) from various studies, including patients from The Cancer Genome Atlas. FGF19 plays a syngeneic function with other signaling pathways in primary liver cancer development, such as epidermal growth factor receptor, Wnt/β-catenin, the endoplasmic reticulum–related signaling pathway, STAT3/IL-6, RAS, and extracellular signal–regulated protein kinase, among others. "

►LINK:

The Role of Fibroblast Growth Factor 19 in Hepatocellular Carcinoma - PMC

Hepatocellular carcinoma (HCC) is the fifth most common type of cancer and the third leading cause of cancer-related deaths worldwide. Liver resection or liver transplantation is the most effective therapy for HCC because drugs approved by the US ...

pmc.ncbi.nlm.nih.gov

&

" Fibroblast growth factor 19 expression correlates with tumor progression and poorer prognosis of hepatocellular carcinoma​

Results​

We found that FGF19 was significantly overexpressed in HCCs as compared with corresponding noncancerous liver tissue. Univariate and multivariate analyses revealed that the tumor FGF19 mRNA expression was an independent prognostic factor for overall and disease-free survival. Moreover, we found that the FGF19 recombinant protein could increase the proliferation and invasion capabilities of human hepatocellular carcinoma cell lines and inhibited their apoptosis. Inversely, decreasing FGF19 and FGFR4 expression by siRNA significantly inhibited proliferation and increased apoptosis in JHH7 cells. The postoperative serum FGF19 levels in HCC patients was significantly lower than the preoperative levels.

Conclusions​

FGF19 is critically involved in the development of HCCs. Targeting FGF19 inhibition is an attractive potential therapeutic strategy for HCC. "

►LINK:

Fibroblast growth factor 19 expression correlates with tumor progression and poorer prognosis of hepatocellular carcinoma - BMC Cancer

Background Although fibroblast growth factor 19 (FGF19) can promote liver carcinogenesis in mice, its involvement in human hepatocellular carcinoma (HCC) has not been well investigated. FGF19, a member of the FGF family, has unique specificity for its receptor FGFR4. This study aimed to clarify...

bmccancer.biomedcentral.com

^^^judging by the number of supporting-studies;
..it seems that the "FCF19" characteristics & effects described above have been well-established ..for some time now


***BTW/FYI/DISCLAIMER;
..i have no horse in this race
..i do not use Humanofort
..i inject ED ..but do not prescribe to Emeric's dosing
..i have nothing against Emeric
..i have respect for Emeric's past accomplishments
→i simply recognized the term "FCF19" from past cancer research
..i had no any idea of Humanofort's connection to FCF19


.

 

[emeric delczeg]

Health issues happens when FGFs are out of range (high or low) from normal range, Humanofort regulates FGFs levels, restores to normal range and restore normal cell communication.

 

[emeric delczeg]

https://www.nature.com/articles/s41392-020-00222-7

 

[emeric delczeg]

Fibroblast Growth Factors in the Management of Acute Kidney Injury Following Ischemia-Reperfusion - PMC

Ischemia-reperfusion injury (IRI), which is triggered by a transient reduction or cessation of blood flow followed by reperfusion, is a significant cause of acute kidney injury (AKI). IRI can lead to acute cell death, tissue injury, and even ...

pmc.ncbi.nlm.nih.gov

 

[emeric delczeg]

6 mounts on Humanofort

 

[SouthernMuscle]

Maybe this should be in the sponsor section

 

[Alan1]

6 mounts on Humanofort

Eh, I'd like some additional context here. Posting those scans and saying "before/after Humanofort" seems to imply that this patient had significant remission of a glioblastoma due to taking Humanofort. Now maybe I'm wrong but methinks perhaps this person simply happened to take Humanofort while undergoing intensive chemo/radiation therapy. If Humanofort has been found to be a breakthrough treatment for cancer (again, those scans and statement seem to be implying so), I figure it'd be quite well known but, I'm not seeing that anywhere.

Sort of like curcumin, which has been shown to have some anti-tumor activity that can be useful when paired with a particular chemotherapy. But no one is going to be like "yeah, I completed a course of chemo and was taking curcumin too....my tumor shrank a lot and it was the curcumin that did it!".

 

[emeric delczeg]

Eh, I'd like some additional context here. Posting those scans and saying "before/after Humanofort" seems to imply that this patient had significant remission of a glioblastoma due to taking Humanofort. Now maybe I'm wrong but methinks perhaps this person simply happened to take Humanofort while undergoing intensive chemo/radiation therapy. If Humanofort has been found to be a breakthrough treatment for cancer (again, those scans and statement seem to be implying so), I figure it'd be quite well known but, I'm not seeing that anywhere.

Sort of like curcumin, which has been shown to have some anti-tumor activity that can be useful when paired with a particular chemotherapy. But no one is going to be like "yeah, I completed a course of chemo and was taking curcumin too....my tumor shrank a lot and it was the curcumin that did it!".

Was no chimo used, I never suggested the the daughter that will cure cancer, all I told here that the Humanofort being 6 times stronger free radical scavenger than glutathione and 11 times stronger than C vitamin. I would never promote for cancer, all I saying that is one of strongest free radical scavenger. Also fantastic result with people suffering with cognitive issues.

 

[emeric delczeg]

Is no any other product (peptides, hormones or non identical hormones) could come even close to the benefits of the Humanofort.
FGFs are expressed in nearly all tissues and they serve essential roles in the earliest stages of embryonic development, during organogenesis, and in the adult, where they function as homeostatic factors that are important for tissue maintenance, repair, regeneration, and metabolism. In general, secreted FGFs function as autocrine or paracrine factors (canonical FGFs; also called paracrine FGFs), however, three members of the secreted FGFs have evolved to function as endocrine factors (endocrine FGFs) with essential roles in the adult where they regulate phosphate, bile acid, carbohydrate and lipid metabolism in addition to the canonical FGF functions that control cell proliferation, differentiation and survival.

 

[BIG_slice]

Is no any other product (peptides, hormones or non identical hormones) could come even close to the benefits of the Humanofort.
FGFs are expressed in nearly all tissues and they serve essential roles in the earliest stages of embryonic development, during organogenesis, and in the adult, where they function as homeostatic factors that are important for tissue maintenance, repair, regeneration, and metabolism. In general, secreted FGFs function as autocrine or paracrine factors (canonical FGFs; also called paracrine FGFs), however, three members of the secreted FGFs have evolved to function as endocrine factors (endocrine FGFs) with essential roles in the adult where they regulate phosphate, bile acid, carbohydrate and lipid metabolism in addition to the canonical FGF functions that control cell proliferation, differentiation and survival.

Is there any benefit to adding HGH when I'm already taking Humanofort (400mg per day)?

 

[Swifto]

Is there any benefit to adding HGH when I'm already taking Humanofort (400mg per day)?

Even though you're a troll, I'll answer as its not a bad question.

I do, as I believe it helps offset with the fatigue of HGH brings me.

2x caps Ecydgrowth (before and after training), 1x cap Humanofort before bed (TD).

2x caps Humanofort (mooring and before bed) (NTD).

1000mg NMN per day split, morning and afternoon.

 

[emeric delczeg]

Is there any benefit to adding HGH when I'm already taking Humanofort (400mg per day)?

No need for HGH when on Humanofort. 400mg OK if train very intense.

Also is the only product that contains both IGF-1 and IGF-2.

Functions and Benefits of IGF-2
IGF-2 is vital for growth and development, particularly during the fetal and childhood stages. It contributes significantly to the development of organs, muscles, and bones. In adults, IGF-2 continues to support muscle growth and repair, aiding in recovery from injuries and maintaining muscle mass., as we age IGF-2 levels diminishes.
In addition to its role in growth, IGF-2 is involved in regulating metabolism. It influences glucose metabolism, helping to maintain balanced blood sugar levels. IGF-2 also affects fat metabolism, potentially aiding in weight management and the prevention of metabolic disorders.
IGF-2 contributes to cognitive health by supporting brain function and cognitive development. Research suggests that IGF-2 may have neuroprotective effects, helping to protect the brain from age-related decline and neurodegenerative diseases. This makes IGF-2 an essential hormone for maintaining overall brain health.

 

[6iron]

I've been using this product for over ten years and consider it a must.

 

[primobolan]

Maybe this should be in the sponsor section

X2

 

[A50#]

I've been working to try and improve my libido and some ED issues so I'm only running a TRT dosage of testosterone right now (I'm also injured right now and unable to train) and I started using Humanofort about a week ago. One thing I've noticed I've been waking up 2-3am with massive boners. Something that's wasn't happening before I started using it.

 

[Flex500]

No need for HGH when on Humanofort. 400mg OK if train very intense.

Also is the only product that contains both IGF-1 and IGF-2.

Functions and Benefits of IGF-2
IGF-2 is vital for growth and development, particularly during the fetal and childhood stages. It contributes significantly to the development of organs, muscles, and bones. In adults, IGF-2 continues to support muscle growth and repair, aiding in recovery from injuries and maintaining muscle mass., as we age IGF-2 levels diminishes.
In addition to its role in growth, IGF-2 is involved in regulating metabolism. It influences glucose metabolism, helping to maintain balanced blood sugar levels. IGF-2 also affects fat metabolism, potentially aiding in weight management and the prevention of metabolic disorders.
IGF-2 contributes to cognitive health by supporting brain function and cognitive development. Research suggests that IGF-2 may have neuroprotective effects, helping to protect the brain from age-related decline and neurodegenerative diseases. This makes IGF-2 an essential hormone for maintaining overall brain health.

we love Emeric...but...

 

[Flex500]

No need for HGH when on Humanofort. 400mg OK if train very intense.

Also is the only product that contains both IGF-1 and IGF-2.

Functions and Benefits of IGF-2
IGF-2 is vital for growth and development, particularly during the fetal and childhood stages. It contributes significantly to the development of organs, muscles, and bones. In adults, IGF-2 continues to support muscle growth and repair, aiding in recovery from injuries and maintaining muscle mass., as we age IGF-2 levels diminishes.
In addition to its role in growth, IGF-2 is involved in regulating metabolism. It influences glucose metabolism, helping to maintain balanced blood sugar levels. IGF-2 also affects fat metabolism, potentially aiding in weight management and the prevention of metabolic disorders.
IGF-2 contributes to cognitive health by supporting brain function and cognitive development. Research suggests that IGF-2 may have neuroprotective effects, helping to protect the brain from age-related decline and neurodegenerative diseases. This makes IGF-2 an essential hormone for maintaining overall brain health.

I have read through almost all of your posts with studies. There is no doubt I may have missed one...BUT...can you produce any with direct, human based clinical evidence showing measurable and signficant increases in IGF-1 or IGF-2 that are similar to HGH or even just substantial?

If you can not product that, this is all largely anecdotal and inundating the board with anecdotal research does not prove out or match the claims you are making.

Again, just one study of direct human based clinical evidence of increased IGF1 and IGF2. Are there any?

 

[M@NU]

I've been using this product for over ten years and consider it a must.

thanks for coming online after over 4 years of abstinence to tell us about your must haves!

 

[TheOtherOne55]

I've been using this product for over ten years and consider it a must.

Why would anyone bump this…
This has been discussed more than the, “why did u get into BBing…” thread

 

[b-boy]

X2

It's a supplement!
Do we move all the creatine, glutamine, BCAA, EAA, taurine threads to the sponsor section under professionalmusclestore?

I hope you see how silly that sounds.

Do we move all the Ozempic and like compounds to the sponsors section also (that would piss a shit load of people off LOL)