Obviously, the more you use the faster you are going to fill out and the more muscle you will gain--for a little while.
The downside to blasting the hell out of the stuff is that your insulin sensitivity goes to shit quick. This is especially true when using GH along with it ...which is also horrible for insulin sensitivity.
If someone is going to use insulin 3X a day, every day, it NEEDS to be for a short period of time. This frequency of use can't be maintained, even with an abundance of insulin sensitizing supplements.
These days I generally recommend pre-workout only use for just about everyone, as it not only the single best time to use insulin (for numerous reasons), but any decrease in sensitivity that accompanies it can usually be countered (potentially in full) with the proper supplementation. This allows for indefinite use.
Any of the crazier programs, such as those involving multi-daily use, Lantus, etc...must be short-term programs only, but these programs aren't good for most people because short-term use, even when using a lot of insulin, isn't going to add much real muscle. It may fill you out like crazy, but that goes away when you go off. With pre-workout only use, the gains may not be as dramatic (they can still be pretty darn good with the proper set-up), but they will be continuous and better for one's long-term progress...not to mention health.
Insulin resistance, especially of the severe variety, will ultimately DAMAGE your physique, especially when maintained for extended periods of time. I am not only talking about a potential gut, but about the deterioration of muscle tissue. Look what happens to diabetics (severe insulin resistance) when their diabetes gets bad enough. Their muscles (especially the limbs) are no longer able to receive adequate nutrients because they cannot get into the cell.
This is because insulin resistance does more than just stop insulin from effectively transporting nutrients to the cell...it also stops them from getting into the cell...because as insulin resistance worsens, Glut-4 refuses to rise to the cell surface. You see, insulin only brings nutrients to the front door of the cell...it doesn't bring them inside the cell where they can be used for recovery and growth. That is the job of Glut-4, but if Glut-4 refuses to come to the cell surface in adequate quantities, it doesn't matter how many nutrients you are consuming...because they won't get in...at least not in optimal quantities.
Unfortunately, muscle cells are the first cells to become insulin resistant, followed by liver cells, then fat cells, then visceral fat cells.
In other words, when muscle cells are no longer able to absorb nutrients like they used to, the remainder of those nutrients will be diverted to the liver, fat cells, and visceral fat cells. As insulin resistance continues to worsen, the muscle cells start to have an even more difficult time absorbing nutrients, but it also begins to affect the liver. As a result, a greater percentage of nutrients are diverted to fat cells and visceral fat cells.
Eventually even fat cells will start to become insulin resistant, which means an even larger percentage of nutrients will begin to be diverted to visceral fat cells. As insulin resistance continues to worsen, each tissue becomes more and more insulin resistant in the order they were affected, with the muscles being the most affected of all.
Visceral fat cells can also become insulin resistant, but they are the absolute last cells to become resistant, s they have a natural "resistance" to insulin resistance.
basically, insulin resistance sucks...and the worse it gets, the more it is going to affect your physique...and health. You may not notice negative physique changes right away, but if it gets bad enough for long enough, you will. Still, even if you don't let it get bad enough so that its negative effects become visible...it is still going to have a negative effect on muscle growth and recovery.
The take home message here is that maintaining insulin sensitivity is vitally important...for both bodybuilding and health purposes. Maintaining great insulin sensitivity makes EVERYTHING bodybuilding related easier.
Guys, I didn't even touch on all the other negative effects insulin resistance will have on the physique, such as fat gain/increased difficulty losing fat.
High-dose, frequent use has a place in certain instances. It can occasionally be useful for helping one break out of a plateau (assuming the individual has excellent insulin sensitivity to begin with and takes steps to minimize resistance), as well as helping one gain maximum size-fullness in the shortest time possible, but again, this is temporary.
These days we've learned that insulin is one of those PEDs that in which the "more is better" approach is NOT better...not even for growth purposes. It may result in more growth initially, but the trade-offs you will experience down the road aren't worth it, not from a physique or health standpoint. Insulin abuse does not make a better bodybuilder--it makes everything worse.