As outlined here -
https://www.professionalmuscle.com/...hen-some-recovery-etc-log.175059/post-3204073 -
I was VERY PLEASANTLY surprised to experience the POLAR opposite of what I was "fearing": not only don't I feel any "hypo" / "hyper" since having pinned (2+ hrs right now, post- 20 mcg IGF-1 LR3), I feel among the most balanced EVER, of ANYTHING I've ever taken to date to help with my hunger / blood sugar. I figured I'd post those details (related to hunger / blood sugar) here:
Overview:
Based on some OLD labs, there is clear evidence (see below) that
postprandially, I was going either modestly HYPO- OR modestly HYPER- glycemic. Despite being rather dated (these labs were taken nearly 20 years ago), and despite, feeling WORLDS BETTER now since those labs were taken, many of the old *patterns* are still present today; although typically to a lesser/much lesser degree. *By this I'm referring to how I feel in response to: certain foods, certain macros, meal timing, and meal quantity).
For example:
For as long as I can remember: I do MUCH BETTER eating BIG / INFREQUENT meals VS LITTLE 'N' OFTEN. And (even now) if "true hunger" prompts me to eat a SMALL quantity of something mid-day, then JUST fruit or JUST protein powder (without fat), or even a small combination of EACH tends to make me feel like shit (hypo OR hyper) a very short while later (i.e. usually within just 30-45 minutes).
Currently, a mid-day snack can be often be achieved without feeling like shit with the addition of some fat (ideally MCTs); but this is FAR LESS effective after an "overnight fast" (i.e. after Meal 1 of the day).
Thus, given that the feeling of hypo/hyper/whatever the hell is going on with me postprandially is MUCH worse: after my 1st meal of the day AND WITHOUT sufficient fat consumed (at any given meal), the fact that I pulled off BOTH this morning (with flying colors) after taking the IGF-1 LR3... then lasted ~1.5 hrs before
***TRUE HUNGER prompted me to eat again, is truly amazing and NOT AN ACCIDENT!
***ALSO NOTE: I've said this in my other post but it's worth saying again: "objectively speaking" the IGF-1 DID NOT trigger "true hunger" either: lately, my NORMAL-sized breakfast (Meal #1) has been around 600-900 calories (with anything under 600 calories being EXCELLENT). The "Meal #1" I'd consumed 15 minutes PRE-pinning the IGF-1 was a mere 166 calories (I kept it small in the event the IGF-1 resulted in me needing to POUND food). Also, even with the [mini] Meal #2, I am under 425 calories = well under MY normal quantity (600-900 calories) consumed by this time of day/late morning)
History/Past Labs:
Consistent with my subjective symptoms at the time, (where I felt what I'd often call this 'NEED TO EAT NOW!!!' feeling (that was TRIGGERED shortly… after eating – i.e. post-prandial hypo?/hyper? glycemia), all labs I had done where bloodwork was pulled shortly after my morning meal (= a balance of carbs / fats / protein, with NO extreme macros), were consistent with what I was feeling: post-prandial glucose was: 43, 64, & 57. Back then (and through the present, as I'll still have basic labs done every 1-2 years), my FASTING blood glucose was/is always normal (usually mid 80's).
The (near 20 yr old) labs from my glucose tolerance w/ insulin challenge "test" painted a VERY DIFFERENT picture "post-prandially" (if you even define the disgusting sugary orange drink as a "meal"). I'm not sure if it's still done this way today, but back then: they'd draw blood at time 0 (which is your fasting labs), then pretty much right after that, they'd hand you this disgusting sugary orange drink, finally, you'd sit in the waiting room and get called back at various timepoints to get more bloodwork pulled. My test was a 2 hr one but I think there is a version of it where labs can be pulled at more time points if one's doctor orders it).
So for me, results were as follows:
Fasting/time zero Glucose: 86 mg/dL (normal range listed: 65 to 99; impaired: 100-125; diabetes: > 125)
Fasting/time zero Insulin: 4 Micro IU/mL (normal = Less than 17)
1-hr Glucose: 192 mg/dL (normal range listed: "Not established"; impaired: [literally blank]; diabetes: > 200)
1-hr Insulin: 110 Micro IU/mL (normal = 8 to 112)
2-hr Glucose: 121 mg/dL (normal range listed: < 140; "impaired": 140 to 200; and "diabetes still >200)
2-hr Insulin: 151 Micro IU/mL (normal = 5 to 55)
Obviously, (for the parameters at the 1 hr mark), I was pretty damn close to falling in to the "diabetes" range despite the insulin still being within the normal range… yet by the 2 hr mark, glucose was back down to normal but insulin was through the fucking roof (almost 3x higher than the UPPER value of the normal range). Off-memory, I think the doctor had concluded: delayed insulin response, that then led to overcompensation of insulin (hence the insulin surge around the 2 hr mark). However, from what I know now, this is not necessarily correct; i.e. since the 1 hr insulin was normal, we just don't know, (without pulling labs at earlier time points between fasting and the 1 hr mark), if the insulin response really was delayed… more than likely, it was a normal response but there was desensitization (receptors failing to respond to the insulin), thereby leading to the insulin 'surge'.
Despite all of this, (and despite the potential for HGH to lead to hyperglycemia / diabetes if timed wrong / used incorrectly), HGH has done NOTHING but help me over the years and balance me (subjectively) as I've never had post-prandial labs while taking it. That said, I am careful to time HGH well away from meals (ideally shooting for a MINIMUM or 2 hrs on either end, often way longer); and on the RARE occasion where I do have to eat right after pinning, it is virtually 100% protein, like straight up chicken without sauces/seasonings. But given how I've always responded so freaking well to HGH (and many have noted IGF-1 can be rather opposite in terms of the blood-sugar effects), I was preparing for the worst in terms of how IGF-1 might impact me!
Conclusions:
Based on my immediate response to the IGF-1 LR3 thus far (3.25+ hr mark as of right now), which has been EXTREMELY positive and not only demonstrates a total absence of any hypo/hyper symptoms but has actually ELIMINATED the mild to low-grade moderate hypo/hyper symptoms that I'd grown accustomed to living with, it sure seems that my 'current baseline' (i.e. how I subjectively feel, post-prandially, without any HGH, IGF-1, etc. in the system) was actually HYPER- (VS HYPO-) glycemia.
In other words, since IGF-1 is KNOWN to cause HYPO in many, then (if my body was "naturally" going in to a state of HYPO, postprandially (as a result of the IGF-1), I'd expect my "baseline symptoms" to WORSEN; however, this did not happen and instead my "baseline symptoms" were ELIMINATED as a result of the IGF-1; leading me to conclude that the shakiness / inability to concentrate / fatigue (that I still get a touch of after a meal with NOTHING in my system) was in fact HYPER- (VS HYPO-) glycemia.
.gif "IP Gear")
Even while sedentary / eating less, for me to make it past noon with barely over 200 calories in the system = no small feat if making an EFFORT to do so VS today where it happened without me even trying! This is incredible and DOES NOT HAPPEN (on its own / w/ nothing in the system), given MY baseline HIGH hunger.
