IGF-1LR3 for fat loss.??

[Gunsmith]

Anyone using IGF-1LR3 as part of a fat loss protocol???

I read an article a little while back (can’t remember where) that stated people have great results taking it at 10-15mcg every 12hrs. I was wondering if anyone else has tried this or know anything about it. I haven’t used IGF in probably 6-7 years and that was just during bulking so I have no idea what it does for fat loss , or stores

 

[FrancisK]

It definitely tightens you up, as for actually fat loss I’m not so sure because I’ve only ever used it in very short spurts. But you definitely look better on it that’s for sure.....

 

[Matsuo Munefusa]

I've almost always lost bodyfat on IGF. You can tell this is happening because your vascularity stands out harder after a nice 10-20 day IGF run. 10-15mcg may be too low dose for it to happen though....consider the therapeutic doses for children is many many times higher than this...I think you will need more than 10-15mcg dose.

100mcg is a good dose.....

The only time I've had noticeable vascularity on my chest and torso was from a 20 day run on IGF at 100ug/day. Shit was freaky. I almost was kinda embarrassed to take my shirt off at the pool because I had blood veins standing out over my obliques and pecs lol

The thing with IGF though is that it makes me very hungry...so its hard to maintain a deficit on it. You actually go hypoglycemic on it during the peak too (around 1-2 hours after administration) if you don't consume enough carbs. Even 6-10 hours after dosing, you can go hypo on it too. It has a long half life.

 

[Matsuo Munefusa]

Now I'd rather get some real IGF with IGFBP3 (binding protein). The IGFBP3 binds up the IGF and releases it near where it needs to be released. So while the halflife of unbound IGF is short, the IGFBP3 protects the IGF from destruction until it needs to be released.

medicine is called Iplex....each vial contains 40mg of IGF....if only I could find a good source lol

 

[Matsuo Munefusa]

btw, Gunsmith, I don't know if you are using insulin....but be very careful if you combine IGF and insulin. IGF is about 50% homologous to insulin (meaning structurally they are 50% identical molecularly). Their actions are very similar, potent nutrient shuttling. They can both deplete your blood sugar levels FAST.

IGF hypo is no fucking joke, especially if you time the peak of the drug to hit when you're training. You'll be on the floor before you know it if you're in a deficit.

 

[Elvia1023]

I am rushing out but just noticed this. As the others have posted yes it can/will tighten you up. It simply makes you look better so adding it into a fatloss plan would be great. I recall (maybe I am wrong) you don't have that many carbs in your diet and that is a problem as you will need to dose it with carbs. Moreover the 15mcg dose just won't cut it so I would recommend at least 50mcg. If dosing every 12 hours then 50mcg. However I would recommend a larger more infrequent dosing plan. It's an amazing nutrient shuttler so you want to have it with a lot of aminos and carbs. As a result I would recommend putting most of your carbs around training and dosing it then. It has a long active life so I would also add in some carbs later in the day (keep an eye on your blood glucose levels). It would be ideal at the end of a dieting phase when higher carbs (carb up) are used.

 

[sciroxx-lab]

IGF1 has a favorable effect on metabolism, and insulin resistance, how ever it really shines for shading fat if combined with GH,

Hereinafter are a couple of other scientific based data to support the unique synergistic effect of GH and IGF1
http://www.ncbi.nlm.nih.gov/pubmed/9129466
------------conclusions -
GH and IGF-I combined further enhanced fat oxidation while reducing protein catabolism. Serum insulin concentrations were significantly increased by GH but decreased by IGF-I. GH significantly decreased serum total triiodothyronine concentrations and IGF-I significantly decreased serum corticosterone concentrations.

 

[Dog-Slime]

It's great for fat loss for me. My best trick was to just shoot it pre workout with a carb free intra of EAA-BCAA but do a heavy workout that normally you would want a carb drink or HIGH carb meal an hour or two before to get through but would be on a low carb diet prob bout like what uneducated people would call keto. Meaning I'd be super drained after lifting but then I'd still keep off the carbs less I was going hypo and start my cardio would try to hit my normal cutting cardio time while putting in nothing but water or more low carb/carb free aminos. Wasn't that uncommon to go hypo during or after this. I could literally feel fat melting off me though I swear... Depending of the quality of the lr3 I might would have to save the shot for immediately post workout then only do the cardio as some had a much stronger insulin like effect and you don't wanna break into a sugar crazed sweat while under some weight....

 

[Dog-Slime]

Very high dose of amino's was used for the intra and normally had a lower carb but high protein shake about 20 minutes before the shot. Was on nice stack of mast and winny. Lost no muscle(visibly or by strength comparison) doing it that way and promise I could feel the fat heating up and melting it was strange but cool. Was needing to make weight for something rather quickly while holding my strength for the event. I made my target weight and lost no strength doing it that way. And I would have had a decent breakfast normally that may have had oats or something so was able to not get too dangerous with the hypoglycemia

 

[cmryan]

Very high dose of amino's was used for the intra and normally had a lower carb but high protein shake about 20 minutes before the shot. Was on nice stack of mast and winny. Lost no muscle(visibly or by strength comparison) doing it that way and promise I could feel the fat heating up and melting it was strange but cool. Was needing to make weight for something rather quickly while holding my strength for the event. I made my target weight and lost no strength doing it that way. And I would have had a decent breakfast normally that may have had oats or something so was able to not get too dangerous with the hypoglycemia

Did you ever try a similar method with insulin like apidra/humalog or evening novolin-r? Or are the methods of action too different?

 

[Dog-Slime]

Naw the thought has crossed my mind but never have even used actual insulin for anything

 

[sciroxx-lab]

Naw the thought has crossed my mind but never have even used actual insulin for anything

Indeed, and despite the popularity of insulin in portion of this community, there is no justification to incorporate insulin (unless for very special purposes). Insulin will sabotage and harm insulin sensitivity for long run, it's a simple common scientific sense - the exposure of the body to the overwhelming ultra high concentrations of exogenous insulin will decrease the sensitivity of the different tissues to insulin, which will harm both metabolism and anabolism.
Insulin also shown to have no anabolic effect in humans, only anti catabolic effect.
IGF1 on the other hand have a very potent anabolic effect (it's possibly the most anabolic hormone), a pronounced anti catabolic effect, and a favorable metabolic effect along with increased insulin sensitivity

 

[Dog-Slime]

Indeed, and despite the popularity of insulin in portion of this community, there is no justification to incorporate insulin (unless for very special purposes). Insulin will sabotage and harm insulin sensitivity for long run, it's a simple common scientific sense - the exposure of the body to the overwhelming ultra high concentrations of exogenous insulin will decrease the sensitivity of the different tissues to insulin, which will harm both metabolism and anabolism.
Insulin also shown to have no anabolic effect in humans, only anti catabolic effect.
IGF1 on the other hand have a very potent anabolic effect (it's possibly the most anabolic hormone), a pronounced anti catabolic effect, and a favorable metabolic effect along with increased insulin sensitivity

This was what my research led me to believe as well. In fact I concluded that I would just use a form IGF in place of actual exo insuluin as this would be better for any effect. But again not sure if it's bad supply (on more recent attempts with IGF) or if I was lucky and had over-dosed lr3 but most IGF hasn't given me as strong of an insulin like response as the lr3 I was using when the fat was melting... You could feel it in a very real undoubtful way: pumps, hunger, sweats, unquenchable appetite....

 

[Matsuo Munefusa]

very low dose insulin combined with low dose GH is beneficial and will not destroy insulin sensitivity.

I'm talking 1-2iu insulin with 2iu GH + fasted + aminos. Followed by a carb/pro/fat meal 2-3 hours later.

 

[Gunsmith]

very low dose insulin combined with low dose GH is beneficial and will not destroy insulin sensitivity.

I'm talking 1-2iu insulin with 2iu GH + fasted + aminos. Followed by a carb/pro/fat meal 2-3 hours later.

Taking in amino doesn't "break" your fast?
I assume you are doing this before fasted cardio??

 

[Matsuo Munefusa]

Taking in amino doesn't "break" your fast?
I assume you are doing this before fasted cardio??

Gunsmith, yes you are technically right - you're not fasted if you're drinking aminos, technically. I meant you don't wake up and eat oatmeal and have a protein shake. Then do GH/slin/cardio.

Yes, its "fasted" cardio (with EAAs + 1iu insulin + 1-2iu GH).

 

[Joltan]

How much will your blood IGF-1 increase on say a 50mcg/day cycle? Anyone know?

Or even 100mcg, or 20mcg - anyone?

 

[Joltan]

In addition to the above question...

- How is IGF-1 LR3 good for fat loss if it's so similar to Insulin?

According to the current science insulin prevents the burning of fat by inhibiting the enzyme AMPK ,sup>1. This enzyme often triggers the upregulation of fat burning – the rate at which the mitochondria in your cells use fat for energy.

 

[cmryan]

In addition to the above question...

- How is IGF-1 LR3 good for fat loss if it's so similar to Insulin?

According to the current science insulin prevents the burning of fat by inhibiting the enzyme AMPK ,sup>1. This enzyme often triggers the upregulation of fat burning – the rate at which the mitochondria in your cells use fat for energy.

Would that be in reference to endogenous insulin only or exogenously administered insulin as well?

 

[Joltan]

10-15mcg may be too low dose for it to happen though....consider the therapeutic doses for children is many many times higher than this...

Children take IGF-1 LR3?