IGF1-lr3 to potentiate GH metabolic and anabolic effects http://sciroxxonline.com/

[sciroxx-lab]

IGF1-lr3 doesn't show itself in serum IGF1 test, this is a scientific simple fact, the molecule is changed and simply doesn't screened by the ELISA test.

For general knowleddge you may check out here a review on IGF1-lr3 and IGF1 -

http://www.professionalmuscle.com/f...din-igf1-lr3-vs-increlex-prescribed-igf1.html

What I speculate and would like to introduce here is that using IGF1-lr3 does increase circulating IGF1 levels
The member who brought it to my attention is the buck1973 actually. He has to comment here in order to realize where he brought this notion from.

So I tested this theory on an athlete who is close to me -
He's using GH at 4-6 iu a day year round, here is the basic protocol we used -
day 1 - IGF1 serum test morning regular procedue - 343
day 2 - IGF1 serum test 3 hours post 100mcg IGF1 injection - 379
6 days wash out period and repeat -
day 1 - IGF1 serum test morning regular procedue - 350
day 2 - IGF1 serum test 3 hours post 100mcg IGF1 injection - 386

More test in this matter to come, I think that buck1973 will cooperate and investigate this matter thoroughly soon.
It's clear that IGF1-lr3 potentitae the GH effect on target tissues to secrete endogenous IGF1, my hypothesis is that this phenomena stems from the optimizing effect of combined IGF1-lr3 with GH on so many metabolic functions.

As shown in the endocrinologist review here - Metabolic actions of growth hormone: direct and indirect. - PubMed - NCBI - GH may exert metabolic effects either directly or indirectly through increased production of IGF-I. GH administration increases circulating IGF-I levels via stimulation of hepatic synthesis and secretion of IGF-I; it may also enhance local IGF-I synthesis, which exerts paracrine or autocrine effects.

This means that the IGF1-lr3 may potentiate local secretion of growth factor in muscle tissue directly and indirectly through the GH paracrine effect

 

[Dxtod]

Time for the youngin to chip in.... Was just talking to buck.

I typed up a huge paragraph that got deleted when my page refreshed by itself.... 30 mins down the drain. However. Refer to pages 194-196 in the hgh testing thread where I introduced the idea of running LR3 along side GH to push the igf barrier. A few people have told me it only raises igf in localized pools... However I believe where people are forgetting a key factor.... insulin sensitivity caused by lr3.... Insulin sensitivity makes our bodies more acceptive and reactive to insulin, which both in terms have a direct impact on igf levels writhing mammals.

Liver-Specific igf-1 Gene Deletion Leads to Muscle Insulin Insensitivity | Diabetes


As I said.... I had a lot better paragraph typed up. It was beautiful. But this is the cliff noted version of a cliff note version.

 

[Dxtod]

I also have bloodwork to show that during the time I incriminated lr3 my igf increased.... And after 600igf it seems my personal levels of igf seem to curve off... And I had around 100point increase pass my normal "saturation point"

 

[sciroxx-lab]

This is very interesting, you guys introduced this idea then, experimenting is so big factor here, as no clinical data on athletes