Heres some info you may find of interest.
Insulin is released by pancreatic beta cells in response to elevated ATP/ADP ratios . Briefly, when your blood sugar levels rise, your ATP/ADP levels become elevated, inhibiting ATP sensitive potassium ion channels (KATP), altering the membrane potential of the pancreatic cells and causing insulin release. The main thing here is that insulin will not be released unless ATP levels within the cells increase. DNP interferes with the protein complex ATP synthase, which allows for the synthesis of ATP from ADP . Since DNP interferes with a key step in ATP production, obviously ATP levels never elevate within any cell, including pancreatic beta cells. Hence , the feedback system through the KATP channels (at least in regards to insulin release), is disabled, and you effectively make yourself a diabetic while on DNP.
The primary action of insulin in the body is to drive glucose into muscle and liver cells (stored as glycogen) which is converted into ATP. Since DNP reduces ATP production significantly*, it again interferes with insulin production by preventing a significant amount of the glucose that is pushed into cells by insulin from ever being used as energy (at least by the cell). So , what is happening to all of this energy that is being expended through the electron transport chain to turn ADP and Pi into ATP? It’s thrown off as heat, and lots of it . thats the main side effect of DNP, as well as the cause of death if you over dose (over heating from the inside)