No Mike, you throw up smoke screens and diversions when asked to provide burden of proof.
I could care less if anyone on this planet prefers berberine over metformin or vice-versa. I've handed down information on the potential for interactions with berberine, if those who choose too use, to be cautious. I've also handed down optional choices to an adjuvant to aid in the absorption with berberine. Which I'm sure you'll take both of these and regurgitate as if you discovered this upon your own findings.
So no where within this thread or anywhere else have I told other's not to use BBR.
I've really wasted a lot of my time with you on several occasions. Forget not, I'll still provide to those an area of interest to gain more insight than what has been present by you or whom ever else to ensure there's more than just one person's insight. We all gain from this. Even moreso when we insert citations for burden of proof.
I've already responded to this many times. Let me try again. It has not been evaluated for this effect in isolation, but as I said previously, all the other variables have been. My opinion is the opinion of those who do this research, as well as many others. At this point it appears to be the general consensus. This is why I have repeatedly said "take it up with them if you disagree with them", as this is where my belief comes from. Given the circumstances, it is extremely likely that metformin has this effect. I read some information as to "why" this is generally considered to be the case, but the subject matter was a bit to deep for me to understand. However, the conclusion was not.
The bottom line is that metformin, when evaluating
ALL the available evidence, appears to be the worst choice for a bodybuilders due it its ability to reduce AR density and blunt AR function.
At this point, it would be wise for any bodybuilder, given the available evidence, to discontinue metformin in favor of berberine. It is clear you disagree--and that's fine, but you are the only one I have spoken who understands the issues at hand that feels this way. I believe your advice is poor...just like your advice regarding AI's was poor.
Unfortunately, you are the kind of person who demands unquestionable, undeniable clinical proof for everything...and if someone takes a stand in opposition to yours, while lacking this unquestionable proof (regardless of how strong the "evidence" might be), you will do everything in your power to convince people that your way is the right way, even if it means giving bad advice.
This is exactly what you've done here--give BAD advice by telling people you think metformin is better for bodybuilders. You also did this in the thread about AI's. You argued as hard as you possibly could to convince others that all AI's were equally likely to injure their lipid profile, just because you wanted to win the argument. Now, I think most people here knew enough about this subject to realize, despite all your arguments, that it was was horribly misguided advice (this includes every coach I have spoken to on the matter, and basically everyone else, really).
Still, even to this day you deny the difference between AI's in this regard. Why? Because you have little to no real-world experience. You sit in a lab and at the computer, but you aren't actually involved in this industry, so you don't see what happens when people use these drugs. You only have clinical studies to reference when searching for answers, which are great because they really help us out in a lot of ways, but often, the answers just don't exist in clinical medicine. There are many, many "truths" that all bodybuilders hold as such, yet they never have and never will be "proven" clinically. Yet we all accept them.
Maybe I should have said right up front that "all the evidence indicates" and "the general consensus is", but it didn't even occur to me given the (what appears to be a unanimous) belief of those who do this research for a living. My point was to warn people of the side effects and explain why metformin is no longer the best choice for bodybuilders. Just about everything I present as truth is either based on solid evidence or overwhelming real-world experience, and when available, unquestionable clinical "poof". This is true of all good coaches.
A much more grievous action is you giving bad advice just so you can try and win an argument...and don't even say you were just trying to point out that the evidence wasn't irrefutable, as you started this shit WAY before you even read the study and realized it wasn't studied in isolation. That only came up a few pages ago and had nothing to do with 90% of the crap you said here. At this point, no one with a solid grasp of the facts, or who has good intentions, would continue to argue metformin's superiority for bodybuilders--at least no one I have encountered, except you. Why? Because the evidence doesn't favor it--not from a bodybuilding standpoint--and you know this, yet you tried your best to discredit my belief that metformin was no longer the best choice for bodybuilders--with ZERO evidence to show metformin was better (again, this was before you even knew metformin wasn't studied in isolation). All you did to try and win was cast off this new research as irrelevant.
For anyone that is reading this. The truth of the matter is that all evidence shows that metformin is more likely to hinder your bodybuilding progress than berberine. Berberine also appears to have less overall side effects and more health benefits, although much more still needs to be learned. In most cases, nature offers us the better alternative. You should always look there first (almost always), as the remedies nature provides often deliver the benefits we desire without the harsh side effects of prescription drugs. Of course, those in the medical profession will completely disagree with me on this, but those who know better, know better. The AMA is about profit, as are the pharms. The number of people turning to berberine, even for the treatment of diabetes, is astounding. .
Also, when it comes to AI's, I caution you against viewing all AI's as equal in terms of cholesterol values. I know many of you already know this because you've seen the evidence in your own life--your own blood work, but for those of you who don't know, please look into this before making a decision. In general, when listing the 3 main AI's from best to worst (in terms of cholesterol damage), you are going to have aromasin, a-dex, and letrozole. Of course, you can always test this for yourself in your own life via bloodwork. A-dex is sometimes OK, but letrozole is usually the worst.
I know there have been a lot of pages between this thread and the AI thread, but after all of it the truth remains.
1.) Metformin is more likely to hamper your BB'ing efforts
2.) Aromasin, A-dex, and letrozole are not all equal in terms of their ability to affect the lipid profile.