1. Does taking exogenous insulin actually cause it.??
2. Can taking exogenous insulin to lower chronic high BG help fix it.??
3. Can carb cycling or even carb timing help fix it.??
4. At what point when taking exogenous HGH do we need to add take insulin to lower BG.??
5. Exactly when do we know we are actually insulin resistant.??
6. Once we do figure out we are fighting insulin resistance what can we do to fix it.??
From my limited knowledge of prediabetes. I keep carbs low so my A1C is always low < 4-5% and insulin sensitivity stays pretty high. I've never experienced insulin resistance. But from my experience with insulin:
1. Normal doses unlikely but I think getting a lengthy break from insulin spikes altogether is important.
2. In the short-term yeah and fast-acting insulin can speed up the time it takes to lower your bg. But what you really need is extended periods of low bg (weeks and months). Then insulin and metabolic factors will decrease and with diet, stay low until sensitivity slowly improves.
3. Of course. You should be doing this anyway IMO. If you're active like we are, insulin resistance is entirely diet related unless you're diabetic.
4. hGH timing not all that important in my experience, insulin timing much more important but again, you're lighting your cells up with exogenous insulin. Lower your bs and you'll need no or very little insulin timed PWO.
5. When bg stays consistently high from insulin resistance, we lose transportation of nutrients into cells and begin to store them as fat. Check your A1C (test kits available on amazon for 60 bucks for 4 tests A1CNow brand) to get some idea of where your bg has been.
6. Diet again, is key. No simple sugars. Drop pre, intra, post WO simple sugars significantly. You can still have them to maintain good recovery (with or without insulin) but are we growing or recovering our insulin sensitivity? Fast from carbs or do intermittent fasting (cycling, CKD, keto). Do not eat fats and carbs simultaneously on a daily basis. I make that a permanent rule at least for myself. Careful with grains, legumes, and nuts that contain lectins like gluten and WGA and other possible inflammatories and stick to meats (animal proteins in general) and healthy fats, lower glycemic carbs. This is really basic stuff.
Possible supplements/meds:
Lantus (if used sparingly and properly)
Resveratrol
Metformin
If you're concerned about about diabetes in general, here is some relevant additional info on beta cell function and c-peptide sampling for determination of pancreatic function:
"An ADA-sponsored workshop in 2001 concluded unanimously that c-peptide estimation be used as the most appropriate outcome measure for preservation of beta cell function. In recent guidelines developed by the American Association of Clinical Endocrinologists (AACE) and American College of Endocrinology (ACE), documenting the levels of c-peptide is recommended when there is doubt over the diagnosis T1 or T2DM. A recent systematic review supported the diagnostic utility of c-peptide,
recommending its use as the principal baseline measure of insulin deficiency
Conclusions
C-peptide is a useful indicator of beta cell function, allowing discrimination between insulin-sufficient and insulin-deficient individuals with diabetes. Various methods of sampling are available, including a urinary c-peptide to creatinine ratio, fasting serum c-peptide, and stimulated c-peptide. Owing to sensitivity, reproducibility, and convenience of the test, we would recommend glucagon stimulation testing in clinical practice.
C-peptide has been shown to correlate with diabetes type, duration of disease, and age of diagnosis. Interestingly c-peptide has been demonstrated to be associated with microvascular complications.
This requires further study but preliminary evidence suggests that alongside HbA1C, sampling for c-peptide can be used as an integral diagnostic and monitoring tool."
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