Insulin sensivity?: Mk-677 vs (GHRP-2 + ModGRF)

[Landmonster]

Guys,


I'm not sure if anyone has this information, but here is my question. Which peptide stack is better for insulin sensitivity?

A) MK-677 @ 10-25mg per day

or

B) 100mcg GHRP-2 + 100mcg ModGRF @ 3-4x daily dosing


Is there any reason why one stack would be better or worse for insulin sensitivity?

I have gotten good gains from both stacks, and have even combined them for a while. However, recent reading about insulin sensitivity has me worried.

 

[johnjuanb1]

Guys,


I'm not sure if anyone has this information, but here is my question. Which peptide stack is better for insulin sensitivity?

A) MK-677 @ 10-25mg per day

or

B) 100mcg GHRP-2 + 100mcg ModGRF @ 3-4x daily dosing


Is there any reason why one stack would be better or worse for insulin sensitivity?

I have gotten good gains from both stacks, and have even combined them for a while. However, recent reading about insulin sensitivity has me worried.

The 2nd stack is better for insulin sensitivity because it causes a high level GH pulse that returns to baseline after approximately 2 hours, leaving the pituitary gland time to replenish its stores. If HGH is elevated constantly like with synthetic HGH or MK677, then it will cause increase glucogenesis, which will lead to insulin resistance. Your fasted glucose levels will increase. With GHRP2/mod grf there is enough time in between HGH bursts for glucose levels to return to normal.
The studies on MK667 show increased glucose levels as one of the sides just like with synthetic HGH. I don't believe 3-4 GH pulses by ghrp2 will do that.
I still love MK677 best but I think it needs to be cycled off after 2-3 months with a 1 month break to reduce insulin resistance. The same goes for synthetic HGH.

 

[Landmonster]

I am just trying to come up with a practical solution that allows us to constantly use peptides (in varying degrees) without causing insulin resistance.

I have gotten very good gains from peptides, and they always seem to subside when coming off entirely.



If what you say is true...

Would we able to use protocol B year-round?

What if we cycled Protocol A in and out periodically?

example:

Month 1: 100mcg GHRP-2 + 100mcg ModGRF @ 3-4x daily dosing + MK-677
Month 2: 100mcg GHRP-2 + 100mcg ModGRF @ 3-4x daily dosing + MK-677
Month 3: 100mcg GHRP-2 + 100mcg ModGRF @ 3-4x daily dosing + MK-677
Month 4: 100mcg GHRP-2 + 100mcg ModGRF @ 3-4x daily dosing
Month 5: 100mcg GHRP-2 + 100mcg ModGRF @ 3-4x daily dosing
Month 6: 100mcg GHRP-2 + 100mcg ModGRF @ 3-4x daily dosing + MK-677
Month 7: 100mcg GHRP-2 + 100mcg ModGRF @ 3-4x daily dosing + MK-677
Month 8: 100mcg GHRP-2 + 100mcg ModGRF @ 3-4x daily dosing + MK-677
Month 9: 100mcg GHRP-2 + 100mcg ModGRF @ 3-4x daily dosing
Month 10: 100mcg GHRP-2 + 100mcg ModGRF @ 3-4x daily dosing

 

[johnjuanb1]

I am just trying to come up with a practical solution that allows us to constantly use peptides (in varying degrees) without causing insulin resistance.

I have gotten very good gains from peptides, and they always seem to subside when coming off entirely.



If what you say is true...

Would we able to use protocol B year-round?

What if we cycled Protocol A in and out periodically?

example:

Month 1: 100mcg GHRP-2 + 100mcg ModGRF @ 3-4x daily dosing + MK-677
Month 2: 100mcg GHRP-2 + 100mcg ModGRF @ 3-4x daily dosing + MK-677
Month 3: 100mcg GHRP-2 + 100mcg ModGRF @ 3-4x daily dosing + MK-677
Month 4: 100mcg GHRP-2 + 100mcg ModGRF @ 3-4x daily dosing
Month 5: 100mcg GHRP-2 + 100mcg ModGRF @ 3-4x daily dosing
Month 6: 100mcg GHRP-2 + 100mcg ModGRF @ 3-4x daily dosing + MK-677
Month 7: 100mcg GHRP-2 + 100mcg ModGRF @ 3-4x daily dosing + MK-677
Month 8: 100mcg GHRP-2 + 100mcg ModGRF @ 3-4x daily dosing + MK-677
Month 9: 100mcg GHRP-2 + 100mcg ModGRF @ 3-4x daily dosing
Month 10: 100mcg GHRP-2 + 100mcg ModGRF @ 3-4x daily dosing

I think that would work with 4 months on, 2 months off for MK677.
You can also increase insulin sensitivity adding metformin or DNP occasionally.
Testing your blood glucose would be the best way to make sure you're not becoming insulin resistant. If your fasted blood glucose gets too high then drop the MK-677 until it's back to normal.

 

[02z06]

I think that would work with 4 months on, 2 months off for MK677.

You can also increase insulin sensitivity adding metformin or DNP occasionally.

Testing your blood glucose would be the best way to make sure you're not becoming insulin resistant. If your fasted blood glucose gets too high then drop the MK-677 until it's back to normal.

In your opinion what would you say would be "too high," on the glucose?


Sent from my iPhone using Tapatalk

 

[johnjuanb1]

In your opinion what would you say would be "too high," on the glucose?


Sent from my iPhone using Tapatalk

"For someone without diabetes, a fasting blood sugar on awakening should be under 100 mg/dl. Before-meal normal sugars are 70–99 mg/dl. “Postprandial” sugars taken two hours after meals should be less than 140 mg/dl."

I would try to keep close to the above range.