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Interesting tren study in rats

Is there some sort of cognitive deficiency going on here?

There was some study somewhere that "suggested" Trenbolone as a possible "candidate" for TRT, or may I say, HRT. That was in no way a recommendation or anything to do with "the stance here at PM."

Perhaps your deficiencies dont allow you to grasp the definitions of TRT and HRT.

Ak
 
Perhaps your deficiencies dont allow you to grasp the definitions of TRT and HRT.

Ak

Wow, you wanna fight, and you're a fucking ideot.
Go play games with the communicability theorem.
 
That was brilliant. Don't back up anything you've asserted here and start name calling.

What a joke

Ak
 
Some study somewhere, Where?

"What studies like that do show is that Tren and Trest are better candidates for TRT."

That is your assumption, And again TRT has nothing to do with TREN, regardless how you try to spin it smart guy.

BTW since you now want to throw HRT in there, what Hormone is it replacing.


Ak

These are the one's he's referencing.


17?-Hydroxyestra-4,9,11-trien-3-one (trenbolone) exhibits tissue selective anabolic activity: effects on muscle, bone, adiposity, hemoglobin, and p... - PubMed - NCBI

Selective androgen receptor modulators (SARMs) now under development can protect against muscle and bone loss without causing prostate growth or polycythemia. 17β-Hydroxyestra-4,9,11-trien-3-one (trenbolone), a potent testosterone analog, may have SARM-like actions because, unlike testosterone, trenbolone does not undergo tissue-specific 5α-reduction to form more potent androgens. We tested the hypothesis that trenbolone-enanthate (TREN) might prevent orchiectomy-induced losses in muscle and bone and visceral fat accumulation without increasing prostate mass or resulting in adverse hemoglobin elevations. Male F344 rats aged 3 mo underwent orchiectomy or remained intact and were administered graded doses of TREN, supraphysiological testosterone-enanthate, or vehicle for 29 days. In both intact and orchiectomized animals, all TREN doses and supraphysiological testosterone-enanthate augmented androgen-sensitive levator ani/bulbocavernosus muscle mass by 35-40% above shams (P ≤ 0.001) and produced a dose-dependent partial protection against orchiectomy-induced total and trabecular bone mineral density losses (P < 0.05) and visceral fat accumulation (P < 0.05). The lowest doses of TREN successfully maintained prostate mass and hemoglobin concentrations at sham levels in both intact and orchiectomized animals, whereas supraphysiological testosterone-enanthate and high-dose TREN elevated prostate mass by 84 and 68%, respectively (P < 0.01). In summary, low-dose administration of the non-5α-reducible androgen TREN maintains prostate mass and hemoglobin concentrations near the level of shams while producing potent myotrophic actions in skeletal muscle and partial protection against orchiectomy-induced bone loss and visceral fat accumulation. Our findings indicate that TREN has advantages over supraphysiological testosterone and supports the need for future preclinical studies examining the viability of TREN as an option for androgen replacement therapy.

Tissue selectivity and potential clinical applications of trenbolone (17beta-hydroxyestra-4,9,11-trien-3-one): A potent anabolic steroid with reduc... - PubMed - NCBI

Recently, the development of selective androgen receptor modulators (SARMs) has been suggested as a means of combating the deleterious catabolic effects of hypogonadism, especially in skeletal muscle and bone, without inducing the undesirable androgenic effects (e.g., prostate enlargement and polycythemia) associated with testosterone administration. 17beta-Hydroxyestra-4,9,11-trien-3-one (trenbolone; 17beta-TBOH), a synthetic analog of testosterone, may be capable of inducing SARM-like effects as it binds to androgen receptors (ARs) with approximately three times the affinity of testosterone and has been shown to augment skeletal muscle mass and bone growth and reduce adiposity in a variety of mammalian species. In addition to its direct actions through ARs, 17beta-TBOH may also exert anabolic effects by altering the action of endogenous growth factors or inhibiting the action of glucocorticoids. Compared to testosterone, 17beta-TBOH appears to induce less growth in androgen-sensitive organs which highly express the 5alpha reductase enzyme (e.g., prostate tissue and accessory sex organs). The reduced androgenic effects result from the fact that 17beta-TBOH is metabolized to less potent androgens in vivo; while testosterone undergoes tissue-specific biotransformation to more potent steroids, dihydrotestosterone and 17beta-estradiol, via the 5alpha-reductase and aromatase enzymes, respectively. Thus the metabolism of 17beta-TBOH provides a basis for future research evaluating its safety and efficacy as a means of combating muscle and bone wasting conditions, obesity, and/or androgen insensitivity syndromes in humans, similar to that of other SARMs which are currently in development.
 
Thank Stewie I will have to read it.


Ak
 
That was brilliant. Don't back up anything you've asserted here and start name calling.

What a joke

Ak

There's nothing to back up. I made a comment on someone's comment. My whole point is that I made no recommendations.

You have the burden of proof. You wanted to say something serious, so go ahead give us some TRT studies.

But let's circle around again, who cares? There was no basis for this discussion. I made no serious assertions, and you wanted to argue with me over something that was off-base.

So here, I'll tell myself "You need to get a life." And I do need to get a life. That's what I'm working on.
 
Well it is a study, however far stretch to HRT. Less of an effect on prostate, many here would disagree.
 
Here B

Proof: Trenbolone is not Testosterone , Not TRT

Proof: Trenbolone is not accepted as HRT

It has been slapped down repeatedly by the MODS here as such and people promoting it as such .

Ak

There's nothing to back up. I made a comment on someone's comment. My whole point is that I made no recommendations.

You have the burden of proof. You wanted to say something serious, so go ahead give us some TRT studies.

But let's circle around again, who cares? There was no basis for this discussion. I made no serious assertions, and you wanted to argue with me over something that was off-base.

So here, I'll tell myself "You need to get a life." And I do need to get a life. That's what I'm working on.
 
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lets not get lost in translation here ;)

HRT = hormone replacement therapy
TRT = testosterone replacement therapy

neither one of these means that testosterone has to be replaced by testosterone imo, however for TRT obviously testosterone is used

trenbolone as HRT/TRT/whatever does have its place imo. i DO doubt that its healthy or in any way superior to testosterone though, apart from the body comp benefits
 
Please don't take one study on Tren as it is a safe compound. For each one of these studies, you can find 5 that show the exact opposite. I have said for years, that i think Tren is way too harsh for most people to run. If you are not making you living with your body, you have no business running tren. I have read several studies that show tren increases the heart size more than any other compound. Also several studies that show Tren does more damage on your prostrate than any other AAS.

To each their own though.

Are you sure?
 
Loved it in the early 90s but sides to much for me for awhile.

Ak
 
Arimidex and hcg are not part of TRT neitther....

Hrt with mast or tren is the best thing ever!!!
 
If I could be on 100 test 100 mast 100 of tren for life... id give up blasting, give up orals... give up my left nut
 
Yep. Same here. No problem with tren, the second I bring in Mastron Propionate, temper and prostate issue

Si Vis Pacem
 
Sorry fellas I'm not really good at saving links or even remember what sites i found them on. I know i read that at one time, which doesn't mean its true by any means.
 
Please don't take one study on Tren as it is a safe compound. For each one of these studies, you can find 5 that show the exact opposite. I have said for years, that i think Tren is way too harsh for most people to run. If you are not making you living with your body, you have no business running tren. I have read several studies that show tren increases the heart size more than any other compound. Also several studies that show Tren does more damage on your prostrate than any other AAS.

To each their own though.

Would be interested in seeing these studies as well as the ones I have seen seem to be fairly favorable towards tren (studies stewie posted, etc.).

Edit: whoops, don't know why I didn't see your post above mine.
 
Last edited:

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