It seems like this is one of those supplements that is crucial to be taken on an empty stomach for it to work properly.
“When IP6 is recommended, the dose is 2-8gm daily, which should be taken on an empty stomach to avoid interaction with dietary proteins. Consider taking supplemental inositol with IP6 because additional unbound inositol multiplies its therapeutic activity.
Specifically, the normal recommend dosage is 1-2gm per day, taken between meals twice a day to avoid its interaction with protein in the diet. For individuals with a high risk of cancer, cardiovascular disease, kidney stones, etc., 2-4gm per day. Finally, to help existing cancer, 5-8gm per day.”
“. IP6 does also bind to copper, zinc, magnesium, and calcium, so it should always be taken on an empty stomach to avoid depleting dietary minerals.
If taken with food, IP6 will bind important, healthy minerals in the stomach, but will get too loaded up with these minerals to take up much iron. If taken properly, on an empty stomach with a full glass of water, IP6 enters the blood intact, "looking" for minerals to bind and will quickly snap-up unbound iron in blood & tissues.”
“IP6 has been shown to be quite safe to use. It is naturally present in mammalian cells, and it is obtainable from food. However, in food, IP6 is bound to protein. Before it can be absorbed it must be freed from this protein. An enzyme called phytase that is present in both food and the intestinal tract performs this function. The problem is that the power of the phytase enzyme is damaging to the IP6 and renders much of it inactive and therefore less effective. Pure IP6 from a supplement is not protein-bound and is easily absorbed in tact, and able to provide its complete medicinal properties.”
If you take it first thing in the morning how long do you need to wait before you consume something with protein?