Interesting topic. Unfortunately seems like theres not enough personal experiences with IGF-1Lr3. Ive been trying to find more info about it too as far as side effects and everything.
"In the past few years, reports have been accumulating consistently showing that downregulation of the IGF-1R causes apoptosis and growth inhibition of cancer cells.5 A list of tumors or tumor cells affected by IGF-1R targeting includes glioblastoma,19 melanoma,18, 24 neuroblastoma,25 prostate cancer,20 colon cancer,26 rhabdomyosarcoma,27, 28 lung cancer,29 Ewing's sarcoma,30 medulloblastoma31 and others." (Baserga, Peruzzi, Reiss).
The IGF-1 receptor in cancer biology - Baserga - 2003 - International Journal of Cancer - Wiley Online Library
Here's Milos Sarcev on Geard up, he talked about Increlex on here, and how the 3 people he knew got liver cancer using it.
GEARD Up ? GEARD UP ? Episode 37 ? Milos The Mind Sarcev ? Guest Host Matt Porter
These are relevant for igf1. Correct me if i am wrong but regular igf1 differs from igf1 lr3. lr3 has much lower affinity for the binding proteins.
Growth Factor Raises Cancer Risk | Harvard Gazette
i am sure there are studies behind this article. according to it people with high igf1 and low igfbp3 are at 4 times greater risk. so if we assume regular igf1 binds to igfbp3, this means there is less igfbp3 floating free(less protective function in the organism). so if lr3 binds considerably less to the binding proteins, this means there will be more free floating igfbp3 than with regular igf1. so in theory lr3 should be less dangerous than pure igf1.
I don't believe Milos, Increlex is not that great. Short half life, needs binding protein 3 to work. No one is getting jacked on Increlex. Lr3 and Des are 10-20x more potent. Des has the highest affinity for IGF receptor.
LR3 has a much lower binding affinity to all the binding proteins. It has a high affinity for IGF receptor and directly binds to it bypassing BPs. In my opinion, LR3 jas no such cancer risks.
I don't believe Milos, Increlex is not that great. Short half life, needs binding protein 3 to work. No one is getting jacked on Increlex. Lr3 and Des are 10-20x more potent. Des has the highest affinity for IGF receptor.
I'm not smart enough to refute what either Milos, or you state. I know from just looking at this forum, tons of guys have used IGF without many issues, but at the same time the risks are obviously present just like with any compound.
I look at it this way.
Is blasting AAS into oblivion and staying away from GH/IGF due to cancer concerns safer? Not really, AAS will wreck your health if used as the only tool for maximum muscle growth as after a certain dose the negative ramifications will present in your bloodwork and with blood pressure.
Maybe using something like MK or some GH with IGF which will allow igfbp3 to be present might be a good idea.