Stewie
Featured Member / Verified Customer
Featured Member
Kilo Klub Member
Registered
Verified Customer
- Joined
- Feb 3, 2011
- Messages
- 5,576
I'm not a doctor. This is not medical advice.
The link between lipids and cardiovascular health is not well understood. It was first believed high cholesterol was a cardiac risk. Then it LDL. Then VLDL. The standard of care is to control LDL with pharmaceutical intervention. But if you find a doctor who is honest and up to date on the most current literature, they will tell you that we simply don't know. All octogenarians exhibit high cholesterol. Is that something that just happens with age? Is there something casual not yet understood? We don't know. Collections of large datasets that wasn't previously possible, is really throwing a wrench into current understanding of responsible Healthcare.
That is to say, most medical questions are much more complex than many medical professionals will disclose.
Thee ole cholesterol hypothesis continues.
Create problem and label lipoproteins "good and bad" (cholesterol phobia).
Create solution (Statins/PCSK9i/AKCEA-APO(a)-LRX [RNAi antisense]).
So, when HDL turns rouge and losses its functionality of facilitating RCT/antioxidant capacity. Do we now label this lipoprotein (oxHDL/glycated-HDL) "bad" cuz it's now hypothesized to be proatherogenic? Well, there's metformin that puts the brakes on glycation of lipoproteins, in particular that "good" lipoprotein. So there's that.