i was told that 11 oxo is effective at tissue level and not systemic??? but do tell us how that goes
black china lab makes 11 oxo clone and its cheaper fyi
too lazy to do my own but goto pubmed and type 'oxandrolone and gr'
one of the studies showed that var competes with cortisol and inhibits cortisol action,,,that is the scientists added var and cortisol at the same time in the cell expressing GR (cortisol receptor) and AR and var 'won' over cortisol's action
so....if you are on HRT and a gear user,,,var will be a good cortisol controlling agent,,,thats why its good for precontest and so on
from personal experience and lab results i can tell you that test at 750mg/wk did not do sht to control cortisol level,,,maybe it did at tissue level but free cortisol level in blood and saliva were 3 times high when i was hypothyroid,,,something to think about.
halotestin and trenbolone are great too for anti cort effects but you know how they are....