Labs A1c/glucose insulin resistance

[sean1970ss]

So I am really shocked what to do and how to neglect myself to get to such bad a state

Well when your ex wife's son takes your vehicle and murders 3 innocent men, 3 times over the legal limit have multiple million dollar lawsuit's against you. And her oldest tried to shoot and kill me 3 times at my own home the DA did not do shit, you come to your house and find another man in bed with your wife ya its pretty fucked up. Most people would have fuckin folded it up and been gone. So yes PTSD, TRIED TO SURVIVE THE BEST I COULD LOST 60% IN REVENUE BECUASE OF THE PUBLITICY FROM HIS CASES. Let alone the dumbass had my 8 year old in the vehicle with her mother at 2:00am. And no I would have never aloud her to go I was not there when this transpired. It is easy to say smartass remarks but when the shoe is on the other foot whole different story.

 

[bbxtreme]

Well when your ex wife's son takes your vehicle and murders 3 innocent men, 3 times over the legal limit have multiple million dollar lawsuit's against you. And her oldest tried to shoot and kill me 3 times at my own home the DA did not do shit, you come to your house and find another man in bed with your wife ya its pretty fucked up. Most people would have fuckin folded it up and been gone. So yes PTSD, TRIED TO SURVIVE THE BEST I COULD LOST 60% IN REVENUE BECUASE OF THE PUBLITICY FROM HIS CASES. Let alone the dumbass had my 8 year old in the vehicle with her mother at 2:00am. And no I would have never aloud her to go I was not there when this transpired. It is easy to say smartass remarks but when the shoe is on the other foot whole different story.

I don’t think anyone is hating on you. Those are just some extremely bad numbers and I say that as someone who sees a lot of labs.

It sounds like a lot of bad stuff happened in your life and it compounded into bad lifestyle decisions. Shit happens, lesson learned. I would add a GLP to your regimen and take back control of your life- in all aspects.

 

[Neuro1234]

Well when your ex wife's son takes your vehicle and murders 3 innocent men, 3 times over the legal limit have multiple million dollar lawsuit's against you. And her oldest tried to shoot and kill me 3 times at my own home the DA did not do shit, you come to your house and find another man in bed with your wife ya its pretty fucked up. Most people would have fuckin folded it up and been gone. So yes PTSD, TRIED TO SURVIVE THE BEST I COULD LOST 60% IN REVENUE BECUASE OF THE PUBLITICY FROM HIS CASES. Let alone the dumbass had my 8 year old in the vehicle with her mother at 2:00am. And no I would have never aloud her to go I was not there when this transpired. It is easy to say smartass remarks but when the shoe is on the other foot whole different story.

That sounds like a lot bro. But you also gave ZERO context. So on a bodybuilding forum it’s only natural to assume neglect. Not survival. You want better answers, give us some context to you questions.

 

[Reno911]

 

[KingOfSushi]

Well when your ex wife's son takes your vehicle and murders 3 innocent men, 3 times over the legal limit have multiple million dollar lawsuit's against you. And her oldest tried to shoot and kill me 3 times at my own home the DA did not do shit, you come to your house and find another man in bed with your wife ya its pretty fucked up. Most people would have fuckin folded it up and been gone. So yes PTSD, TRIED TO SURVIVE THE BEST I COULD LOST 60% IN REVENUE BECUASE OF THE PUBLITICY FROM HIS CASES. Let alone the dumbass had my 8 year old in the vehicle with her mother at 2:00am. And no I would have never aloud her to go I was not there when this transpired. It is easy to say smartass remarks but when the shoe is on the other foot whole different story.

I’m sorry to hear all of that, but wtf does any of it have to do with your a1c?

 

[KingOfSushi]

That sounds like a lot bro. But you also gave ZERO context. So on a bodybuilding forum it’s only natural to assume neglect. Not survival. You want better answers, give us some context to you questions.

Even then I really don’t see the relevance honestly. You don’t get a 14 a1c by missing a meal or resorting to fast food once a week.

 

[Neuro1234]

Even then I really don’t see the relevance honestly. You don’t get a 14 a1c by missing a meal or resorting to fast food once a week.

You’re correct. I was directing that at his response, like we were supposed to magically know all of that happened and that’s how he got where he’s at.

 

[KingOfSushi]

You’re correct. I was directing that at his response, like we were supposed to magically know all of that happened and that’s how he got where he’s at.

For sure, you made a good point. This is a bodybuilding forum. It’s like posting a pic at 30% bf with this same context and being offended that people say you’re too fat and look like crap.

 

[Stewie]

I’m sorry to hear all of that, but wtf does any of it have to do with your a1c?

His opening statement:

Had my labs done a few weeks ago been awhile. I had not been on any meds for awhile for Type 2. Had some tragedy's in my family and personal life PTSD just jacked in the head not eating right.

Neglecting to adhere to taking his meds for his type-2 diabetes. Suspectfully messing up his sleep- sleep deprivation or fragmentation of sleep. Dysregulation of his SNS pumping out catecholamines releasing too much adrenaline, further inhibiting insulin release for proper glucose metabolism. All of which prompting inflammatory responses, further exacerbating his already uncontrolled type-2. More than likely less physical activity, again mucking up his out of wack glucose metabolism and insulin sensitivity. All related to physiological processing to the unfortunate events in his life.

Rather than kicking a man while he's down. Let's encourage him to seek the help he needs.

 

[KingOfSushi]

His opening statement:

Neglecting to adhere to taking his meds for his type-2 diabetes. Suspectfully messing up his sleep- sleep deprivation or fragmentation of sleep. Dysregulation of his SNS pumping out catecholamines releasing too much adrenaline, further inhibiting insulin release for proper glucose metabolism. All of which prompting inflammatory responses, further exacerbating his already uncontrolled type-2. More than likely less physical activity, again mucking up his out of wack glucose metabolism and insulin sensitivity. All related to physiological processing to the unfortunate events in his life.

Rather than kicking a man while he's down. Let's encourage him to seek the help he needs.

Wasn’t trying to kick when down. I apologize for not catching the original context after the thread bump, I just genuinely didn’t see the connection with the comment I responded to.

To OP, though difficult the best thing to do in a time like this is take care of yourself.

 

[Stewie]

Wasn’t trying to kick when down. I apologize for not catching the original context after the thread bump, I just genuinely didn’t see the connection with the comment I responded to.

To OP, though difficult the best thing to do in a time like this is take care of yourself.

My apologies too, I wasn't specifically referring to just your comment. A few individuals have overlooked his original statement, as it appears. Understandably it's easy to do.

Stress can wreak havoc on a lot of systems.

 

[KingOfSushi]

My apologies too, I wasn't specifically referring to just your comment. A few individuals have overlooked his original statement, as it appears. Understandably it's easy to do.

Stress can wreak havoc on a lot of systems.

All good and I appreciate you pointing out the original post

 

[Joltan]

His opening statement:

Neglecting to adhere to taking his meds for his type-2 diabetes. Suspectfully messing up his sleep- sleep deprivation or fragmentation of sleep. Dysregulation of his SNS pumping out catecholamines releasing too much adrenaline, further inhibiting insulin release for proper glucose metabolism. All of which prompting inflammatory responses, further exacerbating his already uncontrolled type-2. More than likely less physical activity, again mucking up his out of wack glucose metabolism and insulin sensitivity. All related to physiological processing to the unfortunate events in his life.

Rather than kicking a man while he's down. Let's encourage him to seek the help he needs.

Not related to the OP, but I have been curious about this exact situation … Would the insulin inhibition still occur if cortisol levels were low, but in presence of high epinephrine? For example, if one was taking a reuptake inhibitor like Wellbutrin which keeps adrenaline levels high, but also in the presence of adrenal fatigue? The low cortisol would usually cause higher insulin sensitivity right, and either insulin overshoots when you eat, or you are extra sensitive to it? Is that still the case if epinephrine is elevated? I assume the presence of epinephrine would prevent gluconeogenesis even further?

 

[Neuro1234]

Wasn’t trying to kick when down. I apologize for not catching the original context after the thread bump, I just genuinely didn’t see the connection with the comment I responded to.

To OP, though difficult the best thing to do in a time like this is take care of yourself.

I’m guilty of missing it too. Apologies to OP. Thank you @Stewie for pointing it out.

 

[Flex500]

Well when your ex wife's son takes your vehicle and murders 3 innocent men, 3 times over the legal limit have multiple million dollar lawsuit's against you. And her oldest tried to shoot and kill me 3 times at my own home the DA did not do shit, you come to your house and find another man in bed with your wife ya its pretty fucked up. Most people would have fuckin folded it up and been gone. So yes PTSD, TRIED TO SURVIVE THE BEST I COULD LOST 60% IN REVENUE BECUASE OF THE PUBLITICY FROM HIS CASES. Let alone the dumbass had my 8 year old in the vehicle with her mother at 2:00am. And no I would have never aloud her to go I was not there when this transpired. It is easy to say smartass remarks but when the shoe is on the other foot whole different story.

Damn...I'm sorry to hear that. That is a lot. You are not the first person to just stop taking care of themselves, including taking critical medications when tragedy strikes. It's important you bounce back out of it though man or you really could be on a terrible path (which you obviously know). Wishing you the best man.

 

[cage99]

Well when your ex wife's son takes your vehicle and murders 3 innocent men, 3 times over the legal limit have multiple million dollar lawsuit's against you. And her oldest tried to shoot and kill me 3 times at my own home the DA did not do shit, you come to your house and find another man in bed with your wife ya its pretty fucked up. Most people would have fuckin folded it up and been gone. So yes PTSD, TRIED TO SURVIVE THE BEST I COULD LOST 60% IN REVENUE BECUASE OF THE PUBLITICY FROM HIS CASES. Let alone the dumbass had my 8 year old in the vehicle with her mother at 2:00am. And no I would have never aloud her to go I was not there when this transpired. It is easy to say smartass remarks but when the shoe is on the other foot whole different story.

@sean1970ss, keep your head up and keep pushing forward! One day at a time should be your mantra! I’m sorry you’re dealing with a tornado of bullshit. Man, my X had my life all fucked up for a period of time too. Fuck that fat busted cunt!

Keep plugging away for your child! They need you around! I’m rooting for you homie!

Cage

 

[Stewie]

Not related to the OP, but I have been curious about this exact situation … Would the insulin inhibition still occur if cortisol levels were low, but in presence of high epinephrine? For example, if one was taking a reuptake inhibitor like Wellbutrin which keeps adrenaline levels high, but also in the presence of adrenal fatigue? The low cortisol would usually cause higher insulin sensitivity right, and either insulin overshoots when you eat, or you are extra sensitive to it? Is that still the case if epinephrine is elevated? I assume the presence of epinephrine would prevent gluconeogenesis even further?

I believe I'm understanding your question correctly?

In the scenario you're describing, it's the opposite, catecholamines- nor/epinephrine stimulates gluconeogenesis, not inhibit.

Could there be a scenario where the presence of transient-acute low levels of cortisol (lessens the overall expression of gluconeogenesis) in the presence of higher than normal nor/epinephrine stimulate gluconeogenesis? Under a normal isolated (without other variables) physiological response could very well stimulate gluconeogenesis through rapid cAMP-mediated mechanism. Presumably this would be short-lived being that cAMP induced is acting as a second messenger that tends to fizzle out rather rapidly after dissociation of G-protein-coupled receptors.

 

[Stewie]

I’m guilty of missing it too. Apologies to OP. Thank you @Stewie for pointing it out.

I had to reread his opening statement. I'm just as guilty

 

[Joltan]

I believe I'm understanding your question correctly?

In the scenario you're describing, it's the opposite, catecholamines- nor/epinephrine stimulates gluconeogenesis, not inhibit.

Could there be a scenario where the presence of transient-acute low levels of cortisol (lessens the overall expression of gluconeogenesis) in the presence of higher than normal nor/epinephrine stimulate gluconeogenesis? Under a normal isolated (without other variables) physiological response could very well stimulate gluconeogenesis through rapid cAMP-mediated mechanism. Presumably this would be short-lived being that cAMP induced is acting as a second messenger that tends to fizzle out rather rapidly after dissociation of G-protein-coupled receptors.

Thanks for the response. I am wondering what the long term effects would likely be in that situation. For example, if you took a situation where a patient has severe adrenal fatigue (let’s say close to adrenal crisis level), they would typically have very low levels of cortisol/epinephrine. However, let’s say the patient is taking a dopamine/norepinephrine reputake inhibitor (like Wellbutrin)… so, assumption would be that epinephrine levels are perhaps normal or possibly even elevated even in the presence of low cortisol.

If i understand correctly, you are saying short term in this environment you would expect a cAMP mediated mechanism (via epinephrine substituting cortisol for gluconeogenesis) to keep blood sugar levels stable? What would you imagine happening long term if no other treatment was ever made? Possibly the body trying to adjust by becoming more insulin sensitive, since it is getting less signaling from catecholamines? Reduced gluconeogenesis as a result of less messengers, but using insulin sensitivity or possibly increased insulin output as compensation?

 

[Stewie]

Thanks for the response. I am wondering what the long term effects would likely be in that situation. For example, if you took a situation where a patient has severe adrenal fatigue (let’s say close to adrenal crisis level), they would typically have very low levels of cortisol/epinephrine. However, let’s say the patient is taking a dopamine/norepinephrine reputake inhibitor (like Wellbutrin)… so, assumption would be that epinephrine levels are perhaps normal or possibly even elevated even in the presence of low cortisol.

If i understand correctly, you are saying short term in this environment you would expect a cAMP mediated mechanism (via epinephrine substituting cortisol for gluconeogenesis) to keep blood sugar levels stable? What would you imagine happening long term if no other treatment was ever made? Possibly the body trying to adjust by becoming more insulin sensitive, since it is getting less signaling from catecholamines? Reduced gluconeogenesis as a result of less messengers, but using insulin sensitivity or possibly increased insulin output as compensation?

I personally don't ascribe to adrenal fatigue. Look at other potential etiologies that may be exacerbating- overlapping an individual with less than stellar physical and/or psychological well-being.

However. With the scenario you're describing better represents models performed either by ex-vivo or in-vitro. You're mentioning two counterregulatory hormones with the addition of insulin receptors as an acceptor. There would be tremendous amount of disruption in several different cell types trying to regulate their actions and survival. Different chaperones, such as heat shock proteins and endoplasmic reticulum resident- unfolded protein response, to name a few that are more than likely loose their function. Ultimately, causing cell dysregulation and/or death of said cell types. Since we're hypothesizing models. Under the aforementioned cell dysfunction, this causes endoplasmic reticulum stress, membrane separation between the mitochondria and endoplasmic reticulum. The endoplasmic reticulum requires a tremendous amount of energy-ATP from the mitochondria to function properly. When there's a wider than normal distance on the associated membrane between these two organelles, energy is limited.

Moving onward to insulin receptors. Guess where insulin receptors in beta cells and islet cells are biosynthesized- you're correct, in the endoplasmic reticulum. When the endoplasmic reticulum encounters uncontrolled stress via fizzled out unfolded protein response, these newly formed insulin receptors can't make it upwards to the cell surface. There will be less ligand (insulin) binding. This is model representation. I'm certain other biochemical pathways would be disrupted to.


To the best of my understanding, NDRIs- such as wellbutrins primary targeting is increasing norepinephrine in brain tissue, namely the prefrontal cortex- via inhibiting reuptake. Its primary action occurs in the central nervous system- prefrontal cortex and not so much directly in the peripheral bloodstream. In peripheral tissue, theoretically could give rise to gluconeogenesis. If there's enough substrates-fatty acids, glucose or ketones.

It's hard pressed to see this scenario take place under a normal physiological reaction. I'd suspect if this did unravel in person with very low cortisol levels- near Addison. Gluconeogenesis would be the last thing a trauma setting would take into consideration.